Results 31 to 40 of about 3,307 (260)

Ubiquitination of ACSL4 by Parkin Suppresses Ferroptosis and Rescues Glucocorticoid‐Induced Bone Loss

open access: yesAdvanced Science, EarlyView.
GCs reduce Parkin, leading to ACSL4 accumulation and PUFA‐phospholipid‐driven ferroptosis in BMSCs, which impairs osteogenesis and promotes adipogenesis, causing GIOP. Parkin restoration (via OE‐Parkin or Parkin‐LNP@DSS6) ubiquitinates and degrades ACSL4, inhibiting ferroptosis, rescuing bone formation, and rescues GIOP bone loss.
Li‐jiang Han   +16 more
wiley   +1 more source

Gran Torino’s Boys and Men with Guns: Hmong Perspectives [PDF]

open access: yesHmong Studies Journal, 2009
This article discusses the Clint Eastwood film Gran Torino in the context of American popular mis-representations of Hmong and from the perspectives of the film‘s Hmong actors and viewers.
Louisa Schein
doaj  

Microprotein MP104 Promotes Malignant Progression of Colorectal Cancer Through Regulating Protein Translation

open access: yesAdvanced Science, EarlyView.
A previously unrecognized microprotein, MP104, encoded by ZEB1‐AS1, emerges as a critical driver of colorectal cancer progression. MP104 links ubiquitin‐mediated protein degradation with translational reprogramming via the UBE2O–AMPKα2–mTOR–EIF4B axis, revealing an unrecognized layer of oncogenic regulation.
Fang Chen   +14 more
wiley   +1 more source

Chao Fa Movies: The Transnational Production of Hmong American History and Identity [PDF]

open access: yesHmong Studies Journal, 2014
Films made by and for particular social and ethnic peoples can reveal a great deal about identity issues. Here, I examine the cultural production, the content, and the socio-cultural and political significance of three Chao Fa-inspired Hmong films ...
Ian G. Baird
doaj  

Polydopamine Nanoparticle‐Mediated Precise Near‐Infrared Optical Stimulation for Cognitive Enhancement

open access: yesAdvanced Science, EarlyView.
Polydopamine nanoparticles enable a precise, non‐genetic, and transcranial neuromodulation strategy via near‐infrared photothermal stimulation. By activating TRPV1 channels, this approach specifically enhances hippocampal gamma oscillations, thereby rescuing spatial memory deficits in models of perioperative neurocognitive disorder.
Yan‐Bo Zhou   +10 more
wiley   +1 more source

From a Refugee Camp to the Minnesota State Senate: A Case Study of a Hmong American Woman’s Challenge [PDF]

open access: yesHmong Studies Journal, 2006
This paper explores the contested nature of Hmong women’s traditional roles and the recent emergence of Hmong American women leaders by discussing Senator Mee Moua, who was elected to the Minnesota State Legislature in January 2002.
Taeko Yoshikawa
doaj  

AI‐Assisted Engineering of Glycyrrhizic Acid/Simvastatin Nanocrystals for Multifunctional Treatment of Bacterial Osteomyelitis

open access: yesAdvanced Science, EarlyView.
Through AI‐assisted screening from FDA‐approved API to overcome the limitations of bacterial osteomyelitis treatment, glycyrrhizic acid and simvastatin are identified as a multifunctional combination capable of self‐assembling into mechanism‐targeting nanocrystals that effectively neutralize reactive oxygen species, suppress M1 macrophage polarization,
Yu Han   +11 more
wiley   +1 more source

Hmong Parents’ Perceptions on Instructional Strategies for Educating their Children with Disabilities [PDF]

open access: yesHmong Studies Journal, 2004
This article reports how Hmong parents were involved in an educational research study to examine their views on a structured reading instruction protocol developed in English and then translated into Hmong for Hmong children identified with disabilities.
Halee Vang
doaj  

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

open access: yesAdvanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang   +11 more
wiley   +1 more source

The Hmong Come to Southern Laos: Local Responses and the Creation of Racialized Boundaries [PDF]

open access: yesHmong Studies Journal, 2011
There is a long history of Hmong migrations from the north to south. Most recently, Hmong have begun emerging in the southern-most parts of Laos, including Champasak and Attapeu Provinces, places where they never lived before, and some Hmong have tried ...
Ian G. Baird
doaj  

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