Results 11 to 20 of about 12,162 (244)
Nucleoporin mediated nuclear positioning and silencing of HMR. [PDF]
PLoS ONE, 2011 The organization of chromatin domains in the nucleus is an important factor in gene regulation. In eukaryotic nuclei, transcriptionally silenced chromatin clusters at the nuclear periphery while transcriptionally poised chromatin resides in the nuclear ...
Giulia J Ruben +6 more
doaj +5 more sources
Ketolide agents HMR 3004 and HMR 3647 (telithromycin) inhibit the growth of Plasmodium falciparum in vitro [PDF]
African Health Sciences, 2016 Background: Malaria is on the increase due to emergence of parasite drug resistance and there is thus an urgent need for the development of new antiparasitic drugs effective at low concentrations.
Mbajiorgu, Felix +2 more
core +5 more sources
Molecular Cell, 2005 The silenced HMR domain is restricted from spreading by barrier elements, and the right barrier is a unique t-RNA(THR) gene. We show that sequences immediately flanking the silenced domain were enriched in acetylated, but not methylated, histones, whereas the barrier element was associated with a nucleosome-free region.
Oki, Masaya, Kamakaka, Rohinton T.
openaire +2 more sources
HmR : internationalization strategy for a pharmaceutical intelligence market [PDF]
, 2017 HmR is dedicated to market research and consulting services in the healthcare area, including the ambulatory and hospital markets, giving privilege to data provided by pharmacies.
Ribeiro, Manuel Guilherme Cleto Duarte da Costa
core +3 more sources
Cellular Uptake of Two Fluoroketolides, HMR 3562 and HMR 3787, by Human Polymorphonuclear Neutrophils In Vitro [PDF]
Antimicrobial Agents and Chemotherapy, 2001 ABSTRACT We analyzed the cellular accumulation of two new fluoroketolides, HMR 3562 and HMR 3787, by human polymorphonuclear neutrophils (PMN) in vitro. Both compounds were rapidly taken up by PMN, with a cellular-to-extracellular concentration ratio (C/E) of about 141 (HMR 3562) and 117 (HMR 3787) at 5 min, and this was followed
H, Abdelghaffar, D, Vazifeh, M T, Labro
openaire +2 more sources
In Vitro Activities of Two Ketolides, HMR 3647 and HMR 3004, against Gram-Positive Bacteria [PDF]
Antimicrobial Agents and Chemotherapy, 1999 ABSTRACT The in vitro activities of two new ketolides, HMR 3647 and HMR 3004, were tested by the agar dilution method against 280 strains of gram-positive bacteria with different antibiotic susceptibility profiles, including Staphylococcus aureus , Enterococcus faecalis ,
K, Malathum +3 more
openaire +2 more sources
, 2021 (A) Recombinantly co-expressed HMRdC and LHR do not interact. Western blot showing anti-HA immunoprecipitation in nuclear extracts from Sf21 insect cells transfected with HA-HMR and His-LHR. IP performed with anti-HA antibody and western blot probed with
Natalia Y. Kochanova (11320681) +9 more
core +1 more source
Bronchopulmonary Disposition of the Ketolide Telithromycin (HMR 3647) [PDF]
Antimicrobial Agents and Chemotherapy, 2001 ABSTRACT Telithromycin (HMR 3647) is the first member of a new family of antimicrobials, the ketolides, developed specifically for the treatment of community-acquired respiratory tract infections. Telithromycin has proven in vitro activity against both common and atypical respiratory tract pathogens.
C, Muller-Serieys +6 more
openaire +2 more sources
The Drosophila speciation factor HMR localizes to genomic insulator sites. [PDF]
PLoS ONE, 2017 Hybrid incompatibility between Drosophila melanogaster and D. simulans is caused by a lethal interaction of the proteins encoded by the Hmr and Lhr genes. In D.
Thomas Andreas Gerland +5 more
doaj +1 more source
Two different Hmr mutations interfere differently with HMR interactome and HMR complex formation.
, 2021 Effect of Hmr2-tg (A) and HmrdC-tg (C) mutations on the HMR interaction with the HMR complex components and HP1a. Y-axis represents the Log2 fold-change of HMR2-tg/HMRwt-tg and HMRdC-tg/HMRwt-tg, respectively, calculated after normalization of each ...
Natalia Y. Kochanova (11320681) +9 more
core +1 more source