Results 121 to 130 of about 12,381 (200)

Estrogenic activity of 7-hydroxymatairesinol potassium acetate (HMR/lignantrade mark) from Norway spruce (Picea abies) knots and of its active metabolite enterolactone in MCF-7 cells.

, 2007
Lignans are plant polyphenols which may possess anticancer, antioxidant, antimicrobial, anti-inflammatory and immunomodulatory activities. In particular, the lignan 7-hydroxymatairesinol (HMR/lignanTM, HMR) is a novel precursor of the mammalian lignan ...
MARINO, FRANCA, BOMBELLI, RAFFAELLA MARIA, LUZZANI M, FERRARI, MARCO, LUINI, ALESSANDRA CHIARA, LEGNARO, MASSIMILIANO, COSENTINO, MARCO, RASINI, EMANUELA, CANNE MG, PARACCHINI S, CREMA F, LECCHINI, SERGIO   +11 more
core   +1 more source

Lhr and Hmr repress satellite DNA transcription.

, 2014
(A) Fold increase in satellite transcripts of LhrKO versus Lhr+. Numbers within the bars show normalized reads mapping to each satellite, the numerator from LhrKO and the denominator from Lhr+.
P. R. V. Satyaki (540517), Kevin H-C. Wei (540519), Hojoong Kwak (392623), Patrick M. Ferree (257780), Daniel A. Barbash (117886), S. Aruna (540521), Tawny N. Cuykendall (540518), Nicholas J. Brideau (540520), Shuqing Ji (540522)   +8 more
core   +1 more source

Molecular Dynamics‐Guided Sterol Engineering of mRNA‐Lipid Nanoparticles Reprograms Biodistribution and Enhances Spleen‐Selective Immunity

Advanced Science, Volume 13, Issue 57, 14 October 2026.
Sterol engineering enables precise control of mRNA lipid nanoparticles by tuning membrane organization. Replacing cholesterol with bile acid‐derived sterols redirects protein expression from the liver to the spleen. Notably, CA‐20 LNP enhances antigen‐specific immune responses while exhibiting a favorable safety profile, highlighting sterols as a ...
Sanghyuk Jeon, Seo‐Hyeon Bae, Jungyong Ji, Jisun Lee, Hosam Choi, Min‐Ho Kang, Sang‐In Park, Hyemin Kim, Nakyung Lee, Hajin Lee, Seonghoon Kim, Jungmin Kim, Subin Yoon, Seonghyun Lee, Seongje Cho, Dahyeon Ha, Ayoung Oh, Sohee Jo, Huijeong Choi, Yeeun Lee, Sowon Lee, Hyo‐Jung Park, Gitak Nam, Jisu Shin, Yujin Kang, Wonpil Im, Kiyoun Lee, Jae‐Hwan Nam   +27 more
wiley   +1 more source

Investigation Into the Metabolism and Elimination Behavior of RU 58841, and Its Influence on the Steroid Profile in Humans

Biomedical Chromatography, Volume 40, Issue 10, October 2026.
ABSTRACT RU 58841 is a nonsteroidal antiandrogen, developed for the treatment of androgen‐dependent conditions. This study aimed to characterize the human metabolism of RU 58841 for the first time and to assess its systemic exposure following topical administration.
Aylin Okutan, Oliver Krug, Gregor Fußhöller, Thomas Piper, Mario Thevis   +4 more
wiley   +1 more source

Hyperbox Mixture Regression for process performance prediction in antibody production

Digital Chemical Engineering
This paper addresses the challenges of predicting bioprocess performance, particularly in monoclonal antibody (mAb) production, where conventional statistical methods often fall short due to time-series data’s complexity and high dimensionality.
Ali Nik-Khorasani, Thanh Tung Khuat, Bogdan Gabrys   +2 more
doaj   +1 more source

HMR borders HP1a together with BEAF-32 at the TSS of actively transcribed genes and enhances their transcription.

, 2017
(A) Heatmaps of HMR, HP1a, BEAF-32 [40], Su(Hw), Mod(mdg4), CP190 and CTCF [39] ChIP signals. All signals are centered around the HMR binding sites, clustered according to adjacent HP1a signals and sorted by HMR intensity.
Bo Sun (177052), Andrea Lukacs (3752956), Thomas Andreas Gerland (3752959), Andreas Walter Thomae (3752962), Pawel Smialowski (2947308), Axel Imhof (22181)   +5 more
core   +1 more source

Multi‐Metric EEG Connectivity and Graph Analysis Reveal Altered Resting‐State Networks in Major Depressive Disorder

Brain and Behavior, Volume 16, Issue 10, October 2026.
Abstract Purpose EEG functional‐connectivity studies in major depressive disorder (MDD) have produced inconsistent findings, partly because different estimators capture distinct aspects of neural coupling. We implemented a multi‐metric resting‐state EEG approach combining linear, phase‐based, nonlinear, and graph‐theoretical measures to characterize ...
Sushmit Jahan Rose, A. H. M. Rahmatullah Imon, Rushdania Bushra, Nafis Ahmed, Moha. Tasneem Habib Warid   +4 more
wiley   +1 more source

Exploring the Neuropharmacological Potential of Ligustrum sinense Relevant to Parkinson's Disease: In Vivo and In Silico Study

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Ligustrum sinense (L. sinense) leaf extract exhibited moderate antioxidant activity (DPPH IC50 = 73.56 ± 2.18 µg/mL) and was evaluated for neuropharmacological effects at 200 and 400 mg/kg using elevated plus maze, open‐field, hole‐cross, and hole‐board tests.
Sowmitro Das, S. M. Istiaque Hamim, Md Nazmul Hasan Zilani, Kazi Sneha Chhando, Puza Das, Md Ridoy Hossain, Md. Imtiaz, Jebin Tasmin, Roney Miah, Md. Nazmul Hasan   +9 more
wiley   +1 more source

Thin‐layer drying kinetics and mathematical modelling of osmotically pretreated vacuum dried green chilli

JSFA reports, Volume 6, Issue 10, Page 440-447, October 2026.
Abstract Background Chilli is highly perishable, often requiring drying to extend shelf life. This study assesses and compares the drying kinetics of osmotically pretreated green chilli under vacuum drying conditions while evaluating suitable mathematical models and calculating effective moisture diffusivity and activation energy. Results Sliced chilli
Md. Raihanul Haque, Md. Iftekhar Kabir, Md. Nahidul Islam, Md. Mojaffor Hosain, Md. Sazzat Hossain Sarker   +4 more
wiley   +1 more source

Immunomodulatory activity of the lignan 7-hydroxymatairesinol potassium acetate (HMR/LignanTM) extracted from the heartwood of norway spruce (Picea abies)

, 2010
The pharmacological profile of the lignan 7-hydroxymatairesinol (HMR/lignan, HMR) includes chemopreventive effects, antioxidant properties, and mild proestrogenic activity.
MARINO, FRANCA, Marcello Luzzani, Silvano Paracchini, MAIO, RAMONA CONSUELO, COSENTINO, MARCO, Marco Gioacchino Delle Canne, LECCHINI, SERGIO   +6 more
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