Results 31 to 40 of about 110,951 (290)

Cerebral blood flow is reduced in ME/CFS during head-up tilt testing even in the absence of hypotension or tachycardia: A quantitative, controlled study using Doppler echography

Clinical Neurophysiology Practice, 2020
Objective: The underlying hypothesis in orthostatic intolerance (OI) syndromes is that symptoms are associated with cerebral blood flow (CBF) reduction.
C. (Linda) M.C. van Campen, Freek W.A. Verheugt, Peter C. Rowe, Frans C. Visser   +3 more
doaj   +1 more source

Structural and functional relationship between the receptor recognition and neuraminidase activities of the Newcastle disease virus hemagglutinin-neuraminidase protein: Receptor recognition is dependent on neuraminidase activity

, 2001
The terminal globular domain of the paramyxovirus hemagglutinin-neuraminidase (HN) glycoprotein spike has a number of conserved residues that are predicted to form its neuraminidase (NA) active site, by analogy to the influenza virus neuraminidase ...
Paul J. Mahon, Deng, R.T., Jennifer M. Sauvron, Langedijk, J.P., Anne M. Mirza, Gisela M. Field, Johannes P. Langedijk, Sauvron, J.M., Iorio, R.M., Field, G.M., Ruitang Deng, Mirza, A.M., Mahon, P.J., Ronald M. Iorio   +13 more
core   +1 more source

Humanin: a novel central regulator of peripheral insulin action. [PDF]

PLoS ONE, 2009
Decline in insulin action is a metabolic feature of aging and is involved in the development of age-related diseases including Type 2 Diabetes Mellitus (T2DM) and Alzheimer's disease (AD).
Radhika H Muzumdar, Derek M Huffman, Gil Atzmon, Christoph Buettner, Laura J Cobb, Sigal Fishman, Temuri Budagov, Lingguang Cui, Francine H Einstein, Aruna Poduval, David Hwang, Nir Barzilai, Pinchas Cohen   +12 more
doaj   +1 more source

Compression Stockings Improve Cardiac Output and Cerebral Blood Flow during Tilt Testing in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Patients: A Randomized Crossover Trial

Medicina, 2021
Background and Objectives: Orthostatic intolerance (OI) is a clinical condition in which symptoms worsen upon assuming and maintaining upright posture and are ameliorated by recumbency.
C. (Linda) M. C. van Campen, Peter C. Rowe, Frans C. Visser   +2 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Patients with Hypertensive Nephropathy and Chronic Kidney Disease Might Not Benefit from Strict Blood Pressure Control

Kidney & Blood Pressure Research, 2018
Background/Aims: In patients with chronic kidney disease (CKD) strict blood pressure (BP) control is reno-protective. However, renal benefits from BP control might depend also on the etiology of CKD.
Simone Vettoretti, Lara Caldiroli, Francesca Zanoni, Valeria Azzini, Anna Villarini, Roberto Meazza, Piergiorgio Messa   +6 more
doaj   +1 more source

Worsening Symptoms Is Associated with Larger Cerebral Blood Flow Abnormalities during Tilt-Testing in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)

Medicina, 2023
Background and Objectives: During tilt testing, myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) patients experience an abnormal reduction in cerebral blood flow (CBF).
C. (Linda) M. C. van Campen, Peter C. Rowe, Frans C. Visser   +2 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Subglottic Chicken Bone in a Five Months old Baby

Journal of Nepal Medical Association, 2009
Foreign body aspiration most commonly affects young children,with respiratory symptoms such as wheeze and cough after a choking episode. When the foreign body is fi rst inhaled as per witnessed by the parents or caregiver there is always choking or ...
Sanjay Prakash, C L Bhusal, K Acharya, B K Sinha   +3 more
doaj   +1 more source

Orthostatic Symptoms and Reductions in Cerebral Blood Flow in Long-Haul COVID-19 Patients: Similarities with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Medicina, 2021
Background and Objectives: Symptoms and hemodynamic findings during orthostatic stress have been reported in both long-haul COVID-19 and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), but little work has directly compared patients from ...
C. (Linda) M. C. van Campen, Peter C. Rowe, Frans C. Visser   +2 more
doaj   +1 more source