Results 31 to 40 of about 46,426 (253)

Using ¹H^N amide temperature coefficients to define intrinsically disordered regions: An alternative NMR method [PDF]

Protein Science, 2018
AbstractThis report describes a cost‐effective experimental method for determining an intrinsically disordered protein (IDP) region in a given protein sample. In this area, the most popular (and conventional) means is using the amide (1HN) NMR signal chemical shift distributed in the range of 7.5–8.5 ppm.
Hiroki, Okazaki, Naoki, Matsuo, Takeshi, Tenno, Natsuko, Goda, Yoshiki, Shigemitsu, Motonori, Ota, Hidekazu, Hiroaki   +6 more
openaire   +2 more sources

Postoperative Radiation Therapy Is Indicated for “Low-Risk” Pathologic Stage I Merkel Cell Carcinoma of the Head and Neck Region but Not for Other Locations

Advances in Radiation Oncology
Purpose: The role of postoperative radiation therapy (PORT) in early stage Merkel cell carcinoma (MCC) is controversial. We analyzed the role of PORT in preventing local recurrences (LR) among patients with low-risk, pathologic stage I MCC based on the ...
Marika M. Bierma, BS, BA, Peter H. Goff, MD, PhD, Daniel S. Hippe, MS, Kristina Lachance, MS, Stephanie K. Schaub, MD, Kent Wallner, MD, Yolanda D. Tseng, MD, Jay J. Liao, MD, Smith Apisarnthanarax, MD, Paul Nghiem, MD, PhD, Upendra Parvathaneni, MBBS, FRANZCR   +10 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells

FEBS Open Bio, EarlyView.
Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori, Kohei Kawabata, Takanori Kubo, Takeo Kitazawa, Sae Kanai, Madoka Iwashita, Ami Hayashi, Hiroyuki Nishi, Mikihisa Takano   +8 more
wiley   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Analytical study of the sth-order perturbative corrections to the solution to a one-dimensional harmonic oscillator perturbed by a spatially power-law potential Vper(x) = λxα

AIP Advances, 2021
In this work, we present a rigorous mathematical scheme for the derivation of the sth-order perturbative corrections to the solution to a one-dimensional harmonic oscillator perturbed by the potential Vper(x) = λxα, where α is a positive integer, using ...
Tran Duong Anh-Tai, Duc T. Hoang, Thu D. H. Truong, Chinh Dung Nguyen, Le Ngoc Uyen, Do Hung Dung, Nguyen Duy Vy, Vinh N. T. Pham   +7 more
doaj   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Experimental Study on the Static Behavior of Reinforced Warren Circular Hollow Section (CHS) Tubular Trusses

Applied Sciences, 2018
For truss structures, the question of whether to weld hidden welds or not has been controversial. In the actual construction process of truss structures, the members are usually spot welded in place on the assembly platform, and then welded as a whole ...
Wenwei Yang, Jiankang Lin, Ni-na Gao, Ruhao Yan   +3 more
doaj   +1 more source

Improved detection of house infestations with triatomines using sticky traps: a paired-comparison trial in the Argentine Chaco

Parasites & Vectors, 2020
Background We conducted a matched-pairs trial of three methods for detecting house infestation with triatominae bugs in a well-defined endemic rural area in the Argentine Chaco.
Gustavo Fabián Enriquez, María Carla Cecere, Julián Antonio Alvarado-Otegui, Alejandra Alvedro, María Sol Gaspe, Mariano Alberto Laiño, Ricardo Esteban Gürtler, Marta Victoria Cardinal   +7 more
doaj   +1 more source