Results 91 to 100 of about 123,814 (303)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Observations of the SW Sextantis star DW Ursae Majoris with the Far Ultraviolet Spectroscopic Explorer

, 2003
We present an analysis of the first far-ultraviolet observations of the SW Sextantis-type cataclysmic variable DW Ursae Majoris, obtained in November 2001 with the Far Ultraviolet Spectroscopic Explorer.
Biro I. B., Casares J., Christian Knigge, Cynthia S. Froning, D. W. Hoard, Dhillon V. S., Dickinson R. J., Knox S. Long, Koester D., Norton A. J., Paula Szkody, Rosen S. R., Rosen S. R., Rutten R. G. M., Vogt N., Zhang E.   +15 more
core   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

The 2009-2010 Study of Archaeological Sites on Dubovaya Griva Island

Поволжская археология, 2012
The materials of the 2009-2010 archaeological survey and excavations on the island of Dubovaya Griva located within the bounds of the Nizhnekamsk water reservoir are presented in the article.
Chizhevsky Andrei A. , Lyganov Anton V. , Morozov V. V.   +2 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Circumstellar Disks at White Dwarfs: Observations

, 2011
The current picture painted by the observations of circumstellar dust at white dwarfs, and the consequent atmospheric pollution, is of a surviving planetary system. This chapter recounts in detail both the discovery and empirical characterization of dust
Aannestad, Alcock, Alcock, Allamandola, Allègre, Bannister, Baraffe, Barnbaum, Barstow, Becklin, Beichman, Beichman, Bilikova, Bockelée-Morvan, Brinkworth, Burrows, Canup, Chary, Chayer, Clayton, Davidsson, Debes, Debes, Debes, Debes, Desharnais, Dobbie, Dobbie, Draine, Dufour, Dupuis, Dupuis, Dupuis, Däppen, Eisenstein, Farihi, Farihi, Farihi, Farihi, Farihi, Farihi, Farihi, Farihi, Farihi, Fazio, Ferrario, Fontaine, Friedrich, Friedrich, Gianninas, Graham, Green, Green, Gänsicke, Gänsicke, Gänsicke, Gänsicke, Hansen, Hoard, Holberg, Horne, Houck, Jura, Jura, Jura, Jura, Jura, Jura, Jura, Jura, Jura, Kawka, Kilic, Kilic, Kilic, Kilic, Klein, Kleinman, Koester, Koester, Koester, Koester, Koester, Koester, Lacombe, Lambert, Liebert, Lisse, Lisse, Lisse, Lodders, Malfait, Maxted, McCook, McCord, McLean, Melis, Morbidelli, Mullally, Napiwotzki, Napiwotzki, Paquette, Patterson, Probst, Probst, Rayner, Reach, Reach, Rieke, Schultz, Shipman, Sion, Sion, Skrutskie, Song, Su, Telesco, Thomas, Tokunaga, Tokunaga, Tremblay, van Maanen, van Maanen, Vauclair, von Hippel, Voss, Wachter, Wegner, Wehrse, Weidemann, Werner, Wesemael, Wesemael, Wolff, York, Zuckerman, Zuckerman, Zuckerman, Zuckerman, Zuckerman, Zuckerman, Zuckerman   +141 more
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

JaxNet: Scalable Blockchain Network [PDF]

, 2020
Today's world is organized based on merit and value. A single global currency that's decentralized is needed for a global economy. Bitcoin is a partial solution to this need, however it suffers from scalability problems which prevent it from being mass ...
Emelyanenko, Taras, Leger, Lucas, Manoharan, Vinod, Shyshatsky, Iurii   +3 more
core   +1 more source

Scrupulosity and hoarding

Comprehensive Psychiatry, 2018
Recent evidence suggests that avoiding waste may be a prominent motive to save in hoarding disorder. Such beliefs are reminiscent of scrupulosity obsessions in OCD. This paper reports on three studies examining scrupulosity-like beliefs in hoarding and the development and validation of a measure of material scrupulosity.Study one examined the ...
Frost, RO, Gabrielson, I, Deady, S, Dernbach, KB, Guevara, G, Peebles-Dorin, M, Yap, K, Grisham, JR, Yap, Ann Keong   +8 more
openaire   +5 more sources