Results 191 to 200 of about 3,510 (262)

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

A homozygous splice-site variant in <i>ZMYND10</i> causes primary ciliary dyskinesia with primary infertility in a Chinese family. [PDF]

Front Med (Lausanne)
He J, Lu X, Guo M, Yang B, Zhou X, Liu Y, Fan H, Yang D, Luo H.   +8 more
europepmc   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Megafaunal Rodents: Behaviour and Ecological Roles of Southeast Asian Forest Porcupines. [PDF]

Ecol Evol
McConkey KR, Mena AS, Pura PB, Tunil CMTB, A/L Din HS, Ong L, Campos-Arceiz A, Sinnaveeran SE, Ramarao SD, Wong EP.   +9 more
europepmc   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Case Report: "One Unhealth" approach on fatal consequences of a fire in an animal hoarded home. [PDF]

Front Vet Sci
Kmetiuk LB, da Silva JS, Correa RG, Brositti Terzian CC, Morikawa VM, Biondo AW.   +5 more
europepmc   +1 more source

Navigating Drug Shortages in Obstetric Care. [PDF]

O G Open
Piltch G, Rochelson D, Rochelson B.
europepmc   +1 more source

Direct Synthesis of Glycosyl Chlorides from Thioglycosides. [PDF]

J Org Chem
Hoard DJ, Sutar Y, Demchenko AV.
europepmc   +1 more source