Results 131 to 140 of about 78,982 (256)

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

Hodgkin lymphoma with hypereosinophilia in a pediatric patient: case report and review of the literature. [PDF]

Front Pediatr
Cruz Osorio RM, Navarro-Martin Del Campo RM, Carrasco-Rivera WC, Bruijnzeels-Ponce LP, Gutiérrez-Ortiz JA, Quintero-Buenrostro H, Salceda-Rivera V, Martinez-Albarran MD, Ugalde-Aviña D, Soto Chavez V, Sánchez-Zubieta F, Gonzalez-Ramella O.   +11 more
europepmc   +1 more source

A comprehensive review of cancer‐induced cardiac wasting

British Journal of Pharmacology, EarlyView.
Cancer is frequently accompanied by cachexia, a systemic syndrome characterized by progressive loss of skeletal muscle mass, with or without loss of fat mass. Increasing evidence indicates that cancer can also induce cardiac muscle wasting, which is associated with structural cardiac remodelling, impaired contractile function and the development of ...
Alessia Lena, Muhammad Shahzeb Khan, Ulrich Keller, Lars Bullinger, Dominik P. Modest, Markus S. Anker   +5 more
wiley   +1 more source

Hodgkin lymphoma: EHA Clinical Practice Guidelines for diagnosis, treatment, and follow-up. [PDF]

Hemasphere
Eichenauer DA, André M, Borchmann P, Collins GP, Doherty I, Eich HT, Federico M, Fossa A, Hartmann S, Hutchings M, Illidge T, Kobe C, Plattel WJ, Specht L, Sureda A, Zaucha JM, Zijlstra JM, Aurer I.   +17 more
europepmc   +1 more source

In silico prediction of novel effective combinational treatment of chronic pain in individual patients: A joint white paper of the H2020 QSPainRelief consortium

British Journal of Pharmacology, EarlyView.
Abstract Opioids are prescribed widely for chronic pain despite well‐recognised risks and variable long‐term benefit, reflecting the lack of effective alternatives for many patients. Combination therapies offer a promising strategy to enhance efficacy whilst reducing side effects.
André Mouraux, Solenn Gousset, Beltrán Alvarez, Monica Baiula, Wouter Bakker, Andrea Bedini, Monir Bertayli, Divakar Budda, Robert Carr, Elisabetta Cuna, Óscar Díaz, Nina Donner, Jesús Giraldo, Geert‐Jan Groeneveld, Berfin Gülave, David Guydan, Hemme Hijma, Rafael Maldonado, Pedro Renault, Carlos Rinaudo, Jeroen Elaissaiss‐Schaap, Athan Spiros, Sara Stoeber, Petri Takkala, Daan van Valkengoed, Coen van Hasselt, Elizabeth (Liesbeth) CM de Lange   +26 more
wiley   +1 more source

Rapidly progressive Hodgkin lymphoma causing superior vena cava syndrome in late pregnancy: a case report and literature review. [PDF]

Front Med (Lausanne)
Čančarević-Đajić B, Antonić Z, Božić S, Kantar M, Cerić A, Mikić D, Tomašević-Pavlović S, Berić P.   +7 more
europepmc   +1 more source

Arrhythmias associated with immune checkpoint inhibitor therapy—A clinical perspective

British Journal of Pharmacology, EarlyView.
Immune checkpoint inhibitors (ICIs) have transformed cancer therapy but are associated with a growing spectrum of cardiovascular immune‐related adverse events. Among these, arrhythmias represent a rare yet potentially life‐threatening complication. ICI‐induced arrhythmias encompass a wide clinical spectrum, including atrial arrhythmias, conduction ...
Dong Wang, Melanie Ricke‐Hoch, David Duncker, Johann Bauersachs, Dominik Berliner   +4 more
wiley   +1 more source

Pediatric Lymphoma in Jordan: A Retrospective Single-Center Study of Clinical Presentation, Treatment, and Outcomes. [PDF]

Cureus
Qatawneh MA, Altarawneh M, Alhwayan A, Alzghoul B, Altawarh A, Aljaafreh S, Alrawashdeh H, Abdalnabi A, AbuAli A, Khader M.   +9 more
europepmc   +1 more source

Heart failure medication to prevent cancer therapy–related cardiac dysfunction: A narrative review

British Journal of Pharmacology, EarlyView.
Advances in oncological therapies have improved cancer survival but also have increased the clinical incidence of cancer therapy–related cardiac dysfunction (CTRCD), a spectrum of conditions ranging from subclinical biomarker or strain abnormalities to progressive heart failure and cardiogenic shock.
Fabian Voß, Paul Goerke, Malte Kelm, Amin Polzin   +3 more
wiley   +1 more source

Hodgkins Disease and Pregnancy [PDF]

Acta Radiologica, 1950
openaire   +2 more sources