Phase I dose-escalation study of the mTOR inhibitor sirolimus and the HDAC inhibitor vorinostat in patients with advanced malignancy. [PDF]
, 2016 Preclinical models suggest that histone deacetylase (HDAC) and mammalian target of rapamycin (mTOR) inhibitors have synergistic anticancer activity. We designed a phase I study to determine the safety, maximum tolerated dose (MTD), recommended phase II ...
Falchook, Gerald S. +17 more
core +2 more sources
CD83 is a new potential biomarker and therapeutic target for Hodgkin lymphoma
Haematologica, 2018 Chemotherapy and hematopoietic stem cell transplantation are effective treatments for most Hodgkin lymphoma patients, however there remains a need for better tumor-specific target therapy in Hodgkin lymphoma patients with refractory or relapsed disease ...
Ziduo Li +21 more
doaj +1 more source
GLUT1 expression patterns in different Hodgkin lymphoma subtypes and progressively transformed germinal centers [PDF]
, 2012 Background: Increased glycolytic activity is a hallmark of cancer, allowing staging and restaging with 18F-fluorodeoxyglucose-positron-emission-tomography (PET).
Agostinelli, Claudio +9 more
core +1 more source
Бюллетень сибирской медицины, 2011 126 patients with histological diagnosis of Hodgkin and non-Hodgkin lymphoma were examined using combined positronemission and computed tomography with radiotracer 18F-deoxyglucose. For staging Ann Arbor classification (1971) with Costwolds modification (
I. V. Boikov +2 more
doaj +1 more source
CD30 - the head of TNF-family… or a successful story of brentuximab vedotin [PDF]
Archive of Oncology, 2013 Hodgkin lymphoma and anaplastic large cell lymphoma are malignancies that highly express CD30 antigen on the cell surface. Both are generally curable by standard chemotherapy but refractory diseases and relapses are treatment problems.
Popović Lazar +2 more
doaj +1 more source
Analysis of the association between Epstein Barr virus infection and Hodgkin lymphoma
Bangabandhu Sheikh Mujib Medical University Journal, 2023 Epstein Barr virus plays an important role in the pathogenesis of Hodgkin lymphoma. However, the frequency of its association in Bangladeshi people has not been widely studied. The aim of this study was to determine the association of Epstein Barr virus
Jasmine Akhter Jahan +5 more
doaj +5 more sources
Critical concepts, practice recommendations, and research perspectives of pixantrone therapy in non-Hodgkin lymphoma: a SIE, SIES, and GITMO consensus paper [PDF]
, 2016 Objectives: In this paper, we present a review of critical concepts and research perspectives and produce recommendations on the optimal use of pixantrone in non-Hodgkin lymphoma (NHL) by group discussion from an expert panel appointed by the Italian ...
Barosi, Giovanni +7 more
core +1 more source
Epstein-Barr virus latent membrane protein-1 expression in Hodgkin lymphoma
Bangabandhu Sheikh Mujib Medical University Journal, 2018 Expression of latent membrane protein-1 of Epstein-Barr virus is documented in Hodgkin lymphoma indicating its relationship in disease process.
Ferdousy Begum +3 more
doaj +1 more source
Aberrant synaptophysin expression in classic Hodgkin lymphoma
Diagnostic Pathology, 2022 Background Synaptophysin is an immunohistochemical marker for neuroendocrine differentiation and is widely used in pathologic diagnosis. Its expression in malignant lymphoma has not yet been described.
Soyoung Im +3 more
doaj +1 more source
Gastric cancer is the leading cause of death in Italian adult patients with common variable immunodeficiency [PDF]
, 2018 An increased prevalence of malignant lymphoma and of gastric cancer has been observed in large cohorts of patients with common variable immunodeficiency (CVID), the most frequently symptomatic primary immunodeficiency. Surveillance strategies for cancers
Agostini, Carlo +11 more
core +3 more sources