Results 61 to 70 of about 564,426 (377)

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Evaluation of clinical features, treatment approaches and treatment outcomes of children with non-Hodgkin lymphoma

Journal of Contemporary Medicine, 2022
Aim: To evaluate the demographic and clinical characteristics, treatment approaches and outcomes of our pediatric patients with non-Hodgkin lymphoma diagnosed and treated in our center. Material and Methods: Between 2006 and 2002, the oncologic charts of
Kübra Ertan, Serdar Uğraş, Yavuz Köksal, Buket Kara   +3 more
doaj   +1 more source

Incidental finding of lymphoma after septoplasty. [PDF]

, 2016
IntroductionSeptoplasty, or surgical correction of the deviated septum, is an elective, routinely performed rhinologic procedure to address nasal airway obstruction.
Bhuta, Sunita M, Kedeshian, Paul A, Kuan, Edward C, Palma Diaz, Miguel Fernando, Suh, Jeffrey D, Tajudeen, Bobby A   +5 more
core   +2 more sources

Targeting Cancer Cells and Tumor Microenvironment in Preclinical and Clinical Models of Hodgkin Lymphoma Using the Dual PI3Kδ/γ Inhibitor RP6530

Clinical Cancer Research, 2018
Purpose: Tumor-associated macrophages (TAMs) and the hyperactivation of the PI3K/AKT pathway are involved in the pathogenesis of Hodgkin lymphoma and affect disease outcome. Because the δ and γ isoforms of PI3K are overexpressed in Hodgkin/Reed–Sternberg
S. Locatelli, Giuseppa Careddu, S. Serio, F. M. Consonni, A. Maeda, S. Viswanadha, S. Vakkalanka, L. Castagna, A. Santoro, P. Allavena, A. Sica, C. Carlo-Stella   +11 more
semanticscholar   +1 more source

Single‐cell insights into the role of T cells in B‐cell malignancies

FEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

Molecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

Non-Hodgkin and Hodgkin Lymphomas Select for Overexpression of BCLW. [PDF]

, 2017
Purpose: B-cell lymphomas must acquire resistance to apoptosis during their development. We recently discovered BCLW, an antiapoptotic BCL2 family member thought only to contribute to spermatogenesis, was overexpressed in diffuse large B-cell lymphoma ...
Adams, Clare M., Eischen, Christine M., Gong, MD, Jerald Z., Mitra, Ramkrishna   +3 more
core   +1 more source

Positron Emission Tomography Score Has Greater Prognostic Significance Than Pretreatment Risk Stratification in Early-Stage Hodgkin Lymphoma in the UK RAPID Study. [PDF]

, 2019
PURPOSE: Accurate stratification of patients is an important goal in Hodgkin lymphoma (HL), but the role of pretreatment clinical risk stratification in the context of positron emission tomography (PET) -adapted treatment is unclear.
Barrington, SF, Clifton-Hadley, L, Counsell, N, Culligan, D, Hancock, B, Hoskin, P, Illidge, T, Johnson, P, McMillan, A, O'Doherty, MJ, Pettengell, R, Phillips, EH, Popova, B, Radford, J, Townsend, W   +14 more
core   +3 more sources

Subtype-specific and co-occurring genetic alterations in B-cell non-Hodgkin lymphoma

bioRxiv, 2019
B-cell non-Hodgkin’s lymphoma (B-NHL) encompasses multiple clinically and phenotypically distinct subtypes of malignancy with unique molecular etiologies.
Michael R. Green, Non-Hodgkin Lymphoma, Man Chun, John Man-shun Ma, Saber Tadros, Alyssa Bouska, Tayla B. Heavican, Haopeng Yang, Q. Deng, D. Moore, A. Akhter, K. Hartert, N. Jain, Jordan Showell, Sreejoyee Ghosh, L. Street, M. Davidson, Christopher D. Carey, J. Tobin, Deepak Perumal, J. Vose, M. Lunning, A. Sohani, Benjamin J Chen, S. Buckley, L. Nastoupil, R. Davis, J. Westin, N. Fowler, S. Parekh, M. Gandhi, S. Neelapu, D. Stewart, K. Bhalla, J. Iqbal, T. Greiner, S. Rodig, A. Mansoor   +37 more
semanticscholar   +1 more source

Small modifier, big decision: switching to SUMO mode adds weight to cancer stemness in mammary tumors

Molecular Oncology, EarlyView.
Inhibition of protein SUMOylation has been shown to block tumorigenesis; however, the specific mechanisms by which SUMOylation controls the tumor‐initiating capacities remain elusive. Li et al. describe the role of Etv1 SUMOylation in cancer stem cells using mouse models of mammary gland tumorigenesis.
Veronika Yevdokimova, Yannick D. Benoit
wiley   +1 more source