Results 1 to 10 of about 393 (111)

Effect of Topically Administered Chitosan-N-acetylcysteine on Corneal Wound Healing in a Rabbit Model [PDF]

Journal of Ophthalmology, 2017
Purpose. The present study was performed to investigate the effect of topically administered chitosan-N-acetylcysteine (C-NAC) on corneal wound healing in a rabbit model. Methods.
Corinna Fischak, Robert Klaus, René M. Werkmeister, Christine Hohenadl, Martin Prinz, Leopold Schmetterer, Gerhard Garhöfer   +6 more
doaj   +3 more sources

Equação de volume para espécies de Cerrado em Formosa, GO [PDF]

Pesquisa Florestal Brasileira, 2021
O presente trabalho teve como objetivo ajustar modelos para a estimativa de volume de espécies do Cerrado, em Formosa, GO. Foram selecionados de 12 a 15 indivíduos de nove espécies, representando a amplitude das classes diamétricas de cada espécie, na ...
Aline Canetti, Nelson Yoshihiro Nakajima, Evaldo Munoz Braz   +2 more
exaly   +4 more sources

Deep learning differentiates between healthy and diabetic mouse ears from optical coherence tomography angiography images. [PDF]

Ann N Y Acad Sci, 2021
We trained a deep learning algorithm to use skin optical coherence tomography angiograms of the ear to differentiate between healthy and type 2 diabetic mice. The deep learning classification algorithm uses a convolutional neural network architecture and was trained on small patches extracted from the full ear angiograms.
Pfister M, Stegmann H, Schützenberger K, Schäfer BJ, Hohenadl C, Schmetterer L, Gröschl M, Werkmeister RM.   +7 more
europepmc   +2 more sources

Long-Term Biocompatibility of a Highly Viscously Thiol-Modified Cross-Linked Hyaluronate as a Novel Vitreous Body Substitute [PDF]

Frontiers in Pharmacology, 2022
Purpose: In surgical ophthalmology, the treatment of complicated retinal and vitreous diseases is one of the central challenges. For this purpose, the vitreous body is removed as part of the standard therapy and replaced by a temporary tamponade to ...
Jose Hurst, Annekatrin Rickmann, Nele Heider, Christine Hohenadl, Charlotte Reither, Andreas Schatz, Sven Schnichels, Kai Januschowski, Kai Januschowski, Martin S. Spitzer, Martin S. Spitzer   +10 more
doaj   +2 more sources

Novel Vitreous Substitutes in Animal and Human Models: A Systematic Review. [PDF]

Biomed Res Int
Introduction Vitreous substitutes are crucial adjuncts during vitreoretinal surgery for retinal detachment, macular holes, and vitreous hemorrhage. However, current vitreous substitutes pose limitations, including but not limited to their postoperative decrease in visual sharpness, nonfavorable refractive indices, and complications such as glaucoma ...
Solish D, Huo L, Jin TS, Hall B, You EL, Popovic MM, Forman A, Shoichet M, Devenyi R, Ballios BG, Yan P.   +10 more
europepmc   +2 more sources

Efficacy of two different thiol-modified crosslinked hyaluronate formulations as vitreous replacement compared to silicone oil in a model of retinal detachment. [PDF]

PLoS ONE, 2017
The efficacy of two novel artificial vitreous body substitutes (VBS) consisting of highly biocompatible thiolated cross-linked hyaluronic acid (HA)-based hydrogels in comparison to silicone oil in a model of retinal detachment was investigated.
Sven Schnichels, Nele Schneider, Christine Hohenadl, José Hurst, Andreas Schatz, Kai Januschowski, Martin S Spitzer   +6 more
doaj   +2 more sources

Molecularly characterised xenograft tumour mouse models: valuable tools for evaluation of new therapeutic strategies for secondary liver cancers. [PDF]

J Biomed Biotechnol, 2009
To develop and evaluate new therapeutic strategies for the treatment of human cancers, well‐characterised preclinical model systems are a prerequisite. To this aim, we have established xenotransplantation mouse models and corresponding cell cultures from surgically obtained secondary human liver tumours.
Mischek D, Steinborn R, Petznek H, Bichler C, Zatloukal K, Stürzl M, Günzburg WH, Hohenadl C.   +7 more
europepmc   +2 more sources

Ex vivo biophysical characterization of a hydrogel-based artificial vitreous substitute. [PDF]

PLoS ONE, 2019
PurposeTo characterize the biophysical properties of an artificial vitreous body substitute (VBS), which consists of a biocompatible, cross-linked, hyaluronic acid (HA)-based hydrogel, by analysing the VBS's influence on intraocular pressure (IOP) and ...
Kai Januschowski, Sven Schnichels, José Hurst, Christine Hohenadl, Charlotte Reither, Annekatrin Rickmann, Lisa Pohl, Karl-Ulrich Bartz-Schmidt, Martin S Spitzer   +8 more
doaj   +2 more sources

Mouse mammary tumor virus promoter-containing retroviral promoter conversion vectors for gene-directed enzyme prodrug therapy are functional in vitro and in vivo. [PDF]

J Biomed Biotechnol, 2008
Gene directed‐enzyme prodrug therapy (GDEPT) is an approach for sensitization of tumor cells to an enzymatically activated, otherwise nontoxic, prodrug. Cytochrome P450 2B1 (CYP2B1) metabolizes the prodrugs cyclophosphamide (CPA) and ifosfamide (IFA) to produce the cytotoxic substances phosphoramide mustard and isophosphoramide mustard as well as the ...
Klein R, Ruttkowski B, Schwab S, Peterbauer T, Salmons B, Günzburg WH, Hohenadl C.   +6 more
europepmc   +2 more sources

Immunogenicity and protective efficacy of a Vero cell culture-derived whole-virus H7N9 vaccine in mice and guinea pigs. [PDF]

PLoS ONE, 2015
BackgroundA novel avian H7N9 virus with a high case fatality rate in humans emerged in China in 2013. We evaluated the immunogenicity and protective efficacy of a candidate Vero cell culture-derived whole-virus H7N9 vaccine in small animal models ...
Walter Wodal, Michael G Schwendinger, Helga Savidis-Dacho, Brian A Crowe, Christine Hohenadl, Richard Fritz, Peter Brühl, Daniel Portsmouth, Anita Karner-Pichl, Dalida Balta, Leopold Grillberger, Otfried Kistner, P Noel Barrett, M Keith Howard   +13 more
doaj   +2 more sources