Results 51 to 60 of about 1,286,713 (353)

UK emergency preparedness: a holistic local response? [PDF]

, 2008
Purpose – This paper aims to argue that to address the consequences of climate change and variability a greater focus on pre-emergency planning that engages a wider stakeholder group must be adopted.
O'Brien, Geoff
core   +1 more source

Holistic Medicine III: The Holistic Process Theory of Healing [PDF]

The Scientific World JOURNAL, 2003
It is possible to understand the process of healing from a holistic perspective. According to the life mission theory, we can stretch our existence and lower our quality of life when we are in crises, to survive and adapt, and we can relax to increase our quality of life when we later have resources for healing. The holistic process theory explains how
Joav Merrick, Niels Jørgen Andersen, Søren Ventegodt   +2 more
openaire   +4 more sources

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

A holistic multi-methodology for sustainable renovation [PDF]

, 2018
A review of the barriers for building renovation has revealed a lack of methodologies, which can promote sustainability objectives and assist various stakeholders during the design stage of building renovation/retrofitting projects.
Aliakbar Kamari, Bammer, G., Bertalanffy, L. von, Bhaskar, R. A., Boeri, A., Checkland, P., Checkland, P., Checkland, P., Churchman, C., Churchman, C. W., Cross, N., Dallas, M., Degan, G., Denzin, N., Dorst, K., Estkowski, T., Groat, L., Habermas, J., Hillier, F. S., Jackson, M. C., Jayaratna, N., Kamari, A., Kamari, A., Kamari, A., Kamari, A., Kamari, A., Keeney, R. L., Linstow, H. A., Mason, R., McNamara, C., Mitroff, I. I., Näegeli, C., Petkov, D., Poul Henning Kirkegaard, Rossella Corrao, Saaty, T. L., Schunck, C., Simon, H. A., Simonsen, J., Stina Rask Jensen, Triantaphyllou, E., Vo, H. V., Weinberg, G. M., Woyseth, H.   +43 more
core   +3 more sources

Holistic View and Novel Perspective on Ruminal and Extra-Gastrointestinal Methanogens in Cattle

Microorganisms, 2023
Despite the extensive research conducted on ruminal methanogens and anti-methanogenic intervention strategies over the last 50 years, most of the currently researched enteric methane (CH4) abatement approaches have shown limited efficacy. This is largely
Godson Aryee, Sarah M. Luecke, Carl R. Dahlen, Kendall C. Swanson, Samat Amat   +4 more
doaj   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Henberg Takes Holistic Approach [PDF]

, 2009
Long before the whisper of terms like global warming and carbon footprints, before SIGG bottles and reusable shopping bags, Marvin Henberg was already a committed environmental ...
Davis, Laura
core   +1 more source

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

Non-Holistic Meaning Anatomism and the No-Principled-Basis Consideration [PDF]

, 2017
Jerry Fodor and Ernest Lepore (1999/2002) frame the debate over meaning holism in terms of a distinction between meaning atomism and meaning anatomism. The former holds that the meaning of an expression E is determined by some relation between E and some
Yen, Chun-Ping
core   +1 more source

Emergent, self-directed, and self-organized learning: Literacy, numeracy, and the iPod Touch

International Review of Research in Open and Distributed Learning, 2011
This paper uses narrative and storying to retell how two girls ages 5 and 7 continue to make use of an iPod touch to expand their literacy and numeracy.
Carlo Antonio Ricci
doaj   +1 more source