Results 41 to 50 of about 1,339,644 (275)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
The Image of Holland in the Works of Fukuzawa Yukichi
Ежегодник ЯпонияThe history of Japanese-Dutch relations began in 1600, when a ship called De Liefde reached the shores of Japan. In 1609, after an audience with the founder of the Tokugawa dynasty, Shogun Tokugawa Ieyasu, the Dutch managed to obtain an official document
A. B. Sharova
doaj +1 more source
BMC Health Services Research, 2021 Background The role of an advanced practice physiotherapist has been introduced in many countries to improve access to care for patients with hip and knee arthritis.
Susan Robarts +8 more
doaj +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
A pilot dose finding study of pioglitazone in autistic children
Molecular Autism, 2018 Background Pioglitazone is a promising compound for treatment of core autism spectrum disorder (ASD) symptoms as it targets multiple relevant pathways, including immune system alterations.
Lucia Capano +10 more
doaj +1 more source
COUNS-EDU: The International Journal of Counseling and Education, 2023 This study aims to test the effectiveness of Holland career counseling to improve the career maturity of students at the Faith-Based Educational School in Pamekasan. The study design used was an experiment involving as many as 7 students was selected by
Fitriyah Fitriyah +2 more
doaj +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Feasibility of group cognitive behavioural therapy for insomnia (CBT-I) in bipolar disorder
European Psychiatry, 2021 Introduction Euthymic patients with bipolar I and II disorder (BD) often have comorbid insomnia, which is associated with worse outcome. Cognitive behavioral therapy for insomnia (CBT-I) is rarely offered to this population, though preliminary ...
O. Swagemakers +3 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
The Holland broadcast language [PDF]
, 2006 The broadcast language is a programming formalism devised by Holland in 1975, which aims at allowing Genetic Algorithms (GAs) to use an adaptable representation. A GA may provide an efficient method for adaption but still depends on the efficiency of the
Decraene, James
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