Results 51 to 60 of about 1,339,644 (275)
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
The simplification of complex interactions for more inclusive social communication technologies (position paper) [PDF]
, 2005 New technologies, especially smart homes and mobile and ubiquitous technologies have the potential to foster improved quality of life in the older population. Some anticipated benefits are linked to specific applications in areas such as home automation,
Holland, Caroline, Holland, Simon
core
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
Jurnal Agrotek Tropika, 2013 Penelitian ini bertujuan untuk: (1) mengetahui pengaruh jenis tumpangsari pada pertumbuhan dan produksi dua kultivar gladiol, (2) mengetahui respon masing-masing kultivar terhadap jenis tumpangsari, (3) mengetahui jenis kombinasi tumpangsari yang ...
Dewansyah Sabtaki +2 more
doaj +1 more source
Creative Communion: Toward a Spirituality of Work [PDF]
, 1990 Reviewed Book: Holland, Joe. Creative Communion: Toward a Spirituality of Work. New York: Paulist Press, [19--]
Cole-Arnal, Oscar
core +1 more source
, 1993 I discuss the absorption and dispersion of pions in hot matter. A two-loop calculation in the framework of chiral perturbation theory is presented and its result is compactly written in terms of the two- and three-particle forward $\pi \pi$ scattering ...
Bebie +16 more
core +1 more source
Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae
FEBS Open Bio, EarlyView.Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes +32 more
wiley +1 more source
Reflective Composition: the declarative composition of roles to unify objects, roles, and aspects [poster session] [PDF]
, 2004 As bases for object-orientation, both class-based and prototype-based organization have limitations. We argue that roles have significant benefits as a foundation for organizing objects.
Holland, Simon
core