Results 181 to 190 of about 59,107 (312)

Direct evidence for poison use on microlithic arrowheads in Southern Africa at 60,000 years ago. [PDF]

Sci Adv
Isaksson S, Högberg A, Lombard M.
europepmc   +1 more source

Centennial scale benthic foraminiferal record of late Holocene oceanographic variability in Disko Bugt, West Greenland

, 2019
Kerstin Perner, Matthias Moros, Jerry Lloyd, Antoon Kuijpers, Richard J. Telford, Jan Harff   +5 more
openalex   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Widespread abyssal turbidites record megathrust earthquake-triggered landslides and coseismic deformation in the Cascadia subduction zone. [PDF]

Sci Adv
Hill JC, Watt JT, Paull CK, Caress DW, Brothers DS, Arizmendi K, Gwiazda R, Kluesner J, Lundsten E, Nieminski NM, Padgett JS, Paduan JB, Snyder G.   +12 more
europepmc   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Mollusc-based paleoecological investigations of the Late Copper — Early Bronze Age earth mounds (kurgans) on the Great Hungarian Plain

Open Geosciences, 2013
Szilágyi Gábor, Sümegi Pál, Molnár Dávid, Sávai Szilvia   +3 more
doaj   +1 more source

Long-term hydrodynamic changes in marginal estuarine seas: the role of sea level rise and freshwater fluxes. [PDF]

Sci Rep
Stanev EV.
europepmc   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Reconstructing Eocene Antarctic river drainage from provenance analysis of Amundsen Sea embayment sediments. [PDF]

Sci Adv
Marschalek JW, van de Flierdt T, Siddoway CS, Thomson SN, Paxman GJG, Jamieson SSR, Conrad E, Licht KJ, Hemming SR, Bentley MJ, Hillenbrand CD, Smith JA, Klages JP, Fox M, Pastore G, Vermeesch P.   +15 more
europepmc   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source