Results 181 to 190 of about 123,040 (288)

Ancient mitogenomes reveal the genetic relationship among extinct and extant water buffaloes. [PDF]

iScience
Liang XY, Liu XM, Lei XL, Hu Q, Guo X, Song S, Yu C, Yue H, Wang Y, Zhang J, Zhou X, Wang H, Ma L, Zhang H, Mo L, Sun G, Liu L, Chen X, Qin X, Yu H.   +19 more
europepmc   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Advected carbon younger than the sediment fuels microbial metabolism in a pumped deep aquifer. [PDF]

Commun Earth Environ
Mailloux BJ, Ahmed KM, Akter A, Blau S, Bostick B, Buchholz BA, Choudhury I, Ellis T, Harvey C, Khan M, Killough M, Lau Vetter MCY, Michael H, Mozumder R, Scanlan K, Slater G, Trembath-Reichert E, van Geen A.   +17 more
europepmc   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Early Holocene vigorous Black Sea outflow and the onset of sluggish Aegean deep-water convection. [PDF]

Commun Earth Environ
Evangelinos D, Campderrós S, Trias-Navarro S, Garcia Briña C, Paredes Paredes E, Pena LD, Frigola J, Hasiotis T, Rousakis G, Sakellariou D, Cacho I.   +10 more
europepmc   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Developmental plasticity under human management shaped cereal evolution prior to domestication in the Early Holocene southern Levant. [PDF]

Proc Natl Acad Sci U S A
Whitlam J, Flohr P, Bogaard A, Charles M, Finlayson B, Makarewicz CA.   +5 more
europepmc   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Holocene transition from climate-driven to human-dominated wetland dynamics in Sinchang-dong, South Korea. [PDF]

Sci Rep
Cho A, Kim JC, Han M, Kwon J, Lee J, Yi S.   +5 more
europepmc   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source