Results 211 to 220 of about 59,107 (312)

Sedimentation season of an early Holocene event deposit estimated from the reproductive organs of <I>Machilus thunbergii</I>

, 2009
Makiko Kobayashi, Arata Momohara, Hiroko Okazaki, Tozo Okamoto, Seiichi Yanagisawa   +4 more
openalex   +2 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Low variability of the Atlantic Meridional Overturning Circulation throughout the Holocene. [PDF]

Nat Commun
Gerber L, Lippold J, Süfke F, Valk O, Testorf P, Ehnis M, Tautenhahn S, Max L, Chiessi CM, Regelous M, Szidat S, Friedrich O, Pöppelmeier F.   +12 more
europepmc   +1 more source

Constraining the climate of the Western Caucasus from the Late Pleistocene to Holocene through isotopic analysis of speleothems

Manuel Rührer, T. Schneck, O. Ya. Chervyatsova, Р. С. Дбар, Evgeniy S. Zakharov, Yuri Dublyansky, Christoph Spötl, Jonathan L. Baker   +7 more
openalex   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Synchronous mid-Holocene marine and terrestrial deglaciation in the Ross Sea, Antarctica. [PDF]

Nat Commun
Parker RL, Riesselman CR, Truax OJ, Jones RS, Lee JI, Lee MK, Jacobsen G, Rosenheim BE, Subt C, Zawadzki A, Ginnane C, Naeher S, Dunbar G, McKay RM, Levy R, Turnbull J, Yoo KC.   +16 more
europepmc   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Late Holocene fast-ice dynamics around the Northern Victoria Land coast, Antarctica. [PDF]

Nat Commun
Tesi T, Weber ME, Muschitiello F, Dutta D, Belt ST, Pambianco C, Di Roberto A, Silva L, Gariboldi K, Morigi C, Battaglia F, Colizza E, De Santis L, Gallerani A, Aulicino G, Langone L, Giordano P.   +16 more
europepmc   +1 more source

Organic carbon accumulation, Holocene

, 2004
Gesine Mollenhauer, Ralph R Schneider, Tim C. Jennerjahn, Péter Müller, Gerold Wefer   +4 more
openalex   +2 more sources

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source