Results 241 to 250 of about 293,402 (335)

Glaciers in California's Sierra Nevada are likely disappearing for the first time in the Holocene. [PDF]

Sci Adv
Jones AG, Marcott SA, Shakun JD, Lifton NA, Gorin AL, Hidy AJ, Zimmerman SRH, Stock GM, Kennedy TM, Goehring BM, Caffee MA.   +10 more
europepmc   +1 more source

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source

Present and past geocryogenic processes in Mexico: A synopsis [PDF]

, 1994
Heine, Klaus
core  

Bone health: Age-related changes in diaphyseal structural properties among European Holocene humans during the last 9000 years. [PDF]

Sci Adv
Sládek V, Hora M, Wall-Scheffler C, Struška M, Berner M.   +4 more
europepmc   +1 more source

Antibiofilm activity of a chionodracine‐derived peptide by NMR‐based metabolomics of cell‐free supernatant of Acinetobacter baumannii clinical strains

FEBS Open Bio, EarlyView.
KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli, Enrico Landi, Francesco Maiurano, Irene Paris, Rosanna Papa, Marco Artini, Laura Selan, Stefano Borocci, Francesco Buonocore, Esther Imperlini   +9 more
wiley   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Eight millennia of continuity of a previously unknown lineage in Argentina. [PDF]

Nature
Maravall-López J, Motti JMB, Pastor N, Tavella MP, Fabra M, Babot P, Bonomo M, Cornero SE, Lamenza GN, Leon DC, Miranda de Zela PC, Politis GG, Angeletti SC, Cattáneo GR, Dantas M, Drube H, Gonzalez Baroni LG, Hocsman S, Izeta AD, Moralejo RA, Aldazabal V, Basso DM, Bayón C, Couso MG, D'Andrea U, Del Río P, Figueroa GG, Frontini R, Gonzalez ME, Laguens AG, Martínez JG, Messineo PG, Nores B, Olivera DE, Sario GM, Sbattella A, Scabuzzo C, Tavarone AM, Vecchi R, Callan K, Caughran E, Estrada O, Frost T, Iliev L, Kearns A, Kellogg J, Krettek KL, Lawson AM, Mah M, Manjila N, Micco A, Patterson I, Qiu L, Roca-Rada X, Soos G, Webb PA, Workman JN, Rohland N, Patterson N, Lazaridis I, Fehren-Schmitz L, Posth C, Llamas B, Mallick S, Demarchi DA, Cabana GS, Reich D, Nores R.   +67 more
europepmc   +1 more source

TMC4 localizes to multiple taste cell types in the mouse taste papillae

FEBS Open Bio, EarlyView.
Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata, Yoshikazu Saito, Yoichi Kasahara, Wataru Fujii, Takumi Misaka, Tomiko Asakura, Masataka Narukawa   +6 more
wiley   +1 more source

The Response of <i>Krascheninnikovia ceratoides</i> (L.) Gueldenst. to Environmental Changes Since the Mid-Holocene in the Tibetan Antelope Breeding Ground of the Western Kunlun Mountains. [PDF]

Ecol Evol
Huang K, Lai F, Chen M, Song Y, Chen S, Wubuaysan Z, Zhuang X.   +6 more
europepmc   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source