Results 241 to 250 of about 89,718 (313)

Ground squirrel coprolites preserve complex archives of ancient environmental DNA over 700,000 years. [PDF]

Nat Commun
Murchie TJ, Cocker SL, Baleka S, Vogel NA, Natola L, Karpinski E, Tirlea D, Barrera MA, Grant DM, Morien E, Long GS, Rutledge LY, Zazula GD, Jensen BJ, Froese DG, Poinar HN.   +15 more
europepmc   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Archeological data with AI- and physics-based modeling explain typhoon-induced disasters in inland China around 3000 yr B.P. [PDF]

Sci Adv
Ding K, Li S, Ding A, Lu H, Zhang J, Xi D, Huang X, Lou S, Tang X, Qiu X, He L, Ma Y, Lin H, Zhang S, Zhou D, Zhou X, Tan ZM, Fu C, Ge Q.   +18 more
europepmc   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

El Niño modulated Holocene hydroclimate extremes as a dipolar pattern of droughts in northeastern China and floods in southwestern China. [PDF]

Sci Rep
Fan J, Xu H, Zhang F, Jiang H, Zhai D, Shi W, Wei X, Zhang W, Xiao J.   +8 more
europepmc   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

30,000 years of fire history in the Cerrado. [PDF]

Sci Rep
Ledru MP, Franco Cassino R, Escobar-Torrez K, Horák-Terra I, Pivello V.   +4 more
europepmc   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

10,000 years of centennially-resolved climate and sea-level change archived in Svalbard beach-ridge system. [PDF]

Sci Rep
Strzelecki MC, Lindhorst S, Hein CJ, van der Bilt WGM, Kivimaki KE, Kavan J.   +5 more
europepmc   +1 more source

The role of land weathering in carbon consumption and its impact on global carbon cycling since the Last Interglacial period. [PDF]

Sci Rep
Xu S, Wu H, Yuan Y, Chen L, Huang X, Yu Y, Zhang C.   +6 more
europepmc   +1 more source