Results 271 to 280 of about 240,870 (365)

The E3 ubiquitin ligase, RNF219, suppresses CNOT6L expression to exhibit antiproliferative activity

FEBS Open Bio, EarlyView.
We identified RNF219 as a CCR4‐NOT complex‐interacting E3 ubiquitin ligase that targets the CCR4‐NOT subunit CNOT6L for ubiquitination. RNF219 directly binds to the DUF3819 domain of CNOT1 through its putative α‐helix spanning amino acids 521–542. Our findings also suggest that antiproliferative activity of RNF219 is at least partially mediated by ...
Shou Soeda, Melissa Montrose, Akinori Takahashi, Risa Ishida, Sandrine Burriel, Nao Ohmine, Tohru Natsume, Shungo Adachi, Minsoo Kim, Tadashi Yamamoto   +9 more
wiley   +1 more source

A Later Stone Age quartz knapping workshop and fireplace dated to the Early Holocene in Senegal: The Ravin Blanc X site (RBX). [PDF]

PLoS One
Pruvost C, Huysecom E, Garnier A, Hajdas I, Höhn A, Lespez L, Rasse M, Douze K, Soriano S, Fichet V, Saulnier-Copard S, Ndiaye M, Mayor A.   +12 more
europepmc   +1 more source

After the Holocene

After the Holocene: Planetary Politics for Commoners reconsiders recent theorization and reflection on the concept of the commons and the political principle of the common in the light of climate change, biodiversity loss and related forms of planetary disturbance and change, as well as the social and political effects and implications of the planetary.
openaire   +2 more sources

Actin dynamics controlled by IqgC, a RasGAP at the crossroads between the IQGAP and fungal GAP1 families

FEBS Open Bio, EarlyView.
IqgC is a RasGAP from Dictyostelium discoideum. IqgC binds RasG via its RasGAP domain and deactivates it on macroendocytic cups, thereby suppressing the uptake of fluid and particles. IqgC has a positive effect on cell‐substratum adhesion, and its RGCt domain is required for recruitment to ventral foci.
Vedrana Filić, Darija Putar, Lucija Mijanović, Igor Weber   +3 more
wiley   +1 more source

21st Century Sea Ice Loss Will Upend 11,700 Years of Stable Habitat for Bowhead Whales. [PDF]

Ecol Evol
Freymueller NA, Lorenzen ED, Brown SC, Rahbek C, Fordham DA.   +4 more
europepmc   +1 more source

Upper Holocene Paleoceanography of Inner Miramichi Bay

, 1980
F J E Wagner, Charles T. Schafer
openalex   +2 more sources

Characterization of WAC interactions with R2TP and TTT chaperone complexes linking glucose and glutamine availability to mTORC1 activity

FEBS Open Bio, EarlyView.
TTT and R2TP chaperone complexes are required for the assembly and activation of mTORC1. WAC directly interacts with components of TTT, R2TP, and mTORC1, and these interactions are affected by the availability of glucose and glutamine, correlating with changes in mTORC1 activity.
Sofía Cabezudo, Natalia Cuervo, Carmen García‐Martín, Andrés López‐Perrote, Clara Reglero, Adrián Maqueda‐Real, Ana González‐Corpas, Marina Serna, Diego Megías, Alejo Efeyan, Solip Park, Oscar Llorca   +11 more
wiley   +1 more source

Postglacial bioweathering, soil nutrient cycling, and podzolization from palaeometagenomics of plants, fungi, and bacteria. [PDF]

Sci Adv
von Hippel B, Stoof-Leichsenring KR, Çabuk U, Liu S, Melles M, Herzschuh U.   +5 more
europepmc   +1 more source

Polydatin ameliorates ovalbumin‐induced asthma in a rat model through NCOA4‐mediated ferroautophagy and ferroptosis pathway

FEBS Open Bio, EarlyView.
In this research, a rat model of asthma was created using OVA, and polydatin served as an intervention. By inhibiting ferroautophagy mediated by NCOA4 and averting ferroptosis, polydatin has been demonstrated to reduce asthma. This work presents new ideas for investigating the mechanism of polydatin's ability to alleviate asthma, in addition to ...
Wei Li, Yuwei Tang, Wenkang Liu, Fang Fang, Jiepeng Wang, Chaoyi Fang   +5 more
wiley   +1 more source