Results 281 to 290 of about 240,870 (365)

Pleistocene Climate Changes and Lineage Diversification of <i>Sphenarium</i> Grasshoppers (Orthoptera: Pyrgomorphidae). [PDF]

Ecol Evol
Sanabria-Urbán S, Torres-Miranda A, Prieto-Torres DA, Oyama K, Del Castillo RC.   +4 more
europepmc   +1 more source

Blocking the voltage‐gated sodium channel hNav1.5 as a novel pH‐dependent mechanism of action for tamoxifen

FEBS Open Bio, EarlyView.
Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr, Michael Fauler, Thomas Zimmer, Bettina Jungwirth, Hubert Schrezenmeier, David Alexander Christian Messerer   +5 more
wiley   +1 more source

Patterns and drivers of Holocene moisture variability in mid-latitude eastern North America. [PDF]

Nat Commun
Salonen JS, Schenk F, Williams JW, Shuman B, Lindroth Dauner AL, Wagner S, Jungclaus J, Zhang Q, Luoto M.   +8 more
europepmc   +1 more source

Changes in Benthic Foraminifer Assemblages across the Holocene/Pleistocene Boundary, Sites 619, 620, 621, 622, and 624, Deep Sea Drilling Project Leg 96

, 1986
C. J. Schroeder
openalex   +1 more source

An optimized protocol to detect high‐throughput DNA methylation from custom targeted sequences on 96 samples simultaneously

FEBS Open Bio, EarlyView.
Workflow of a high‐throughput technology for epigenotyping of differentially methylated CpGs in specific regions of the genome. The protocol works with small amounts of DNA extracted from blood or semen. The protocol consists of both enzymatic conversion of unmethylated cytosines and capture by hybridization with a custom panel.
Nathalie Iannuccelli, Sophie Valière, Julien Sarry, Cécile Donnadieu, Julie Demars   +4 more
wiley   +1 more source

North Atlantic climate change and Late Holocene windstorm activity in the Outer Hebrides, Scotland [PDF]

, 2011
Dawson, Alastair, Dawson, Sue, Jordan, Jason   +2 more
core  

Cultural, economic, and settlement shifts over the last 9,000 years at Kakapel Rockshelter, Western Kenya. [PDF]

PLoS One
Goldstein ST, Mueller NG, Finestone E, Sawchuk EA, Juengst S, Otwani AO, Miller JM, Langley MC, Fernandes R, Steinhof A, Iminjili V, Chepkorir C, Janzen A, Ogola C, Ndiema E, Petraglia M, Boivin N.   +16 more
europepmc   +1 more source

Teaching Python with team‐based learning: using cloud‐based notebooks for interactive coding education

FEBS Open Bio, EarlyView.
This study presents a novel approach to teaching Python and bioinformatics using team‐based learning and cloud‐hosted notebooks. By integrating interactive coding into biomedical education, the method improves accessibility, student engagement, and confidence—especially for those without a computing background.
Nuno S. Osório, Leonardo D. Garma
wiley   +1 more source

A holocene n-alkane stable isotope record from Wonderwerk Cave, South Africa and its implications for the later stone age record. [PDF]

Sci Rep
Ecker M, Rhodes S, Andersen N, Horwitz LK, Chazan M, Makarewicz CA.   +5 more
europepmc   +1 more source

Downregulation of sST2, a decoy receptor for interleukin‐33, enhances subcutaneous tumor growth in murine pancreatic cancer cells

FEBS Open Bio, EarlyView.
Subcutaneous implantation of murine Panc02 pancreatic cancer cells depleted of sST2, a soluble decoy receptor for the proinflammatory interleukin‐33 (IL‐33), leads to a decreased number of GLUT4‐positive cancer‐associated adipocytes, reduced levels of the anti‐inflammatory molecule adiponectin, increased phosphorylation of IκBα, elevated Cxcl3 ...
Miho Akimoto, Nobuko Koshikawa, Takao Morinaga, Mimi Tamamori‐Adachi, Atsushi Takatori, Keizo Takenaga   +5 more
wiley   +1 more source