Background Childhood adversity is associated with increased risks of long‐term social welfare dependence in young adulthood. Mental health problems may mediate this relation, but evidence remains lacking. Methods 613,643 individuals from the Danish Life Course cohort (DANLIFE) were categorized into five trajectory groups based on their annual exposure ...
Tjeerd Rudmer de Vries +6 more
wiley +1 more source
Predicting individual dry matter intake in Holstein × Gyr cows using behavior-monitoring sensor, phenotypic, and weather data with supervised machine learning. [PDF]
da Silva CS +9 more
europepmc +1 more source
Safety of upadacitinib in atopic dermatitis in randomized clinical trials across 6 years
The current study found no evidence of cumulative increased safety risks with upadacitinib 15 or 30 mg for up to 6 years and over 9000 patient‐years of safety data in adults and adolescents. There were low rates of adjudicated major adverse cardiovascular events, adjudicated thromboembolic events and malignancies. Abstract Background Atopic dermatitis (
Christopher G. Bunick +13 more
wiley +1 more source
Delphi consensus: First‐line use of biologics and small molecules in hidradenitis suppurativa
This Delphi Consensus study identified upgrade criteria for the use of biologics and small molecules as first‐line therapy in hidradenitis suppurativa (HS). European HS experts evaluated 16 clinical scenarios, voting on eligibility for therapy escalation.
Georgios Nikolakis +54 more
wiley +1 more source
Overcoming the challenge of persistent left atrial appendage thrombosis: a case report of successful left atrial appendage occlusion using a cerebral protection system. [PDF]
Althoff D +3 more
europepmc +1 more source
Role of comorbidities and medication on immunotherapy efficacy in cSCC: A DeCOG multicentre analysis
Immunosuppressive disease was associated with reduced overall survival, while anticoagulant use was linked to prolonged progression‐free survival in advanced cutaneous squamous cell carcinoma treated with immune checkpoint inhibitors. Host‐related factors may modulate immunotherapy efficacy and warrant prospective validation.
Glenn Geidel +27 more
wiley +1 more source
Comparative Fluctuating Asymmetry and Directional Asymmetry in Four Cattle Skulls. [PDF]
Manuta N +7 more
europepmc +1 more source
European S2k guidelines on management of autoimmune blistering diseases in children and adolescents
Autoimmune blistering disorders (AIBDs) in children are rare, challenging to diagnose and treat and often require immunosuppressants. Until now, no paediatric care guidelines existed. The EADV Task Force for AIBDs has developed the consensus‐based recommendations, enabling physicians to adopt a uniform, tailored treatment strategy to improve outcomes ...
A. Nanda +31 more
wiley +1 more source
Impacts of hoof disorders on milk yield in cattle: a systematic review with meta-analysis. [PDF]
Freitas JLDP +4 more
europepmc +1 more source

