Results 11 to 20 of about 152,081 (303)

Hombre mosca acompañado de una mujer y otros hombres durante un espectáculo en la plaza de toros.

open access: yes, 1935
Un hombre sostiene en la mano un periódico con noticia de heridos en el camino a Cuautla.
Casasola (photographer)
core   +3 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Effect of Biofloc Culture on the Daily Rhythmicity of the Activity and Expression of Digestive Enzymes in Tilapia, Oreochromis niloticus

open access: yesAquaculture Nutrition
Biofloc technology (BFT) has recently attracted great attention due to minimal water exchange and reduced feed intake. This study aimed to recognize daily changes in the digestive physiology of Oreochromis niloticus between a traditional system and BFT ...
María del Carmen Monroy-Dosta   +7 more
doaj   +1 more source

SEXUAL ABUSE IN CHILDHOOD AND ADULT DRUG ADDICTION [PDF]

open access: yesPapeles del Psicólogo, 2013
This article reviews several studies on the relationship between having been sexually abused in childhood (CSA) and adult drug addiction. In this approach to the subject, seventeen studies and three books that relate the two variables are discussed.
Fernando Perez del Río   +1 more
doaj  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

La razón y el absurdo en la obra de Leon Battista Alberti

open access: yesStudia Aurea: Revista de Literatura Española y Teoría Literaria del Renacimiento y Siglo de Oro, 2012
Uno de los rasgos más destacados de la producción de Leon Battista Alberti (1404-1472) es la formulación de dos visiones del mundo simultáneas y contradictorias.
Mariana Sverlij
doaj   +1 more source

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