Results 51 to 60 of about 61,303 (258)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Polypharmacy and Potential Drug–Drug Interactions in Home-Dwelling Older People – A Cross-Sectional Study

Journal of Multidisciplinary Healthcare, 2021
Monica Hermann,1 Nina Carstens,2 Lars Kvinge,1 Astrid Fjell,1,3 Marianne Wennersberg,4 Kjersti Folleso,5 Knut Skaug,6 Ake Seiger,7 Berit Seiger Cronfalk,3,8 Anne-Marie Bostrom1,3,9 1Department of Health and Caring Sciences, Western Norway University of ...
Hermann M, Carstens N, Kvinge L, Fjell A, Wennersberg M, Folleso K, Skaug K, Seiger A, Cronfalk BS, Bostrom AM   +9 more
doaj  

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Relationship between Visual Attention Patterns and Subjective Evaluations in Housing Sales Information: A Study Using Eye-Tracking Technology

Buildings
Traditionally, studies analyzing consumer preferences in real estate have focused on measuring subjective user responses, neglecting associated physiological responses.
Carla de-Juan-Ripoll, María Luisa Nolé, Antoni Montañana, Carmen Llinares   +3 more
doaj   +1 more source

End‐of‐life care management for older adults at home by multidisciplinary professionals in Japan

Journal of General and Family Medicine, 2023
Background Population aging is a global phenomenon, and there is an urgent need to establish community‐based integrated care systems for a sustainable society.
Akiko Kaneda, Yuka Kanoya
doaj   +1 more source

Reliability of HOME FAST BRAZIL—Self-Reported Version for Community-Dwelling Older Adults

Frontiers in Public Health, 2021
Objective: Verify the intra- and inter-rater reliability of the HOME FAST BRAZIL—Self-reported version and correlate household environmental risks with the history of falls by community-dwelling older adults.Method: Cross sectional study with 50 ...
Karina Stella Aoki Ferreira, Tamires Terezinha Gallo da Silva, Jarbas Melo Filho, Jarbas Melo Filho, Natacha Verônica Bazanella, Audrin Said Vojciechowski, Lynette Mackenzie, Anna Raquel Silveira Gomes   +7 more
doaj   +1 more source

Determinants of a sense of insecurity among home-dwelling older people. [PDF]

Scand J Public Health, 2022
Aims: A sense of insecurity may have an impact on older people’s well-being and their courage to engage actively in meaningful activities. Studies on a sense of insecurity among older people are scarce. The aim of this study was to determine the extent to which home-dwelling older adults perceive their life as being insecure and how a sense of ...
Knuutila MT, Lehti TE, Karppinen H, Kautiainen H, Strandberg TE, Öhman H, Savikko NM, Jansson AH, Pitkälä KH.   +8 more
europepmc   +3 more sources

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Optimising medication management for polymedicated home-dwelling older adults with multiple chronic conditions: a mixed-methods study protocol

BMJ Open, 2019
Introduction Optimal medication management is one of the basic conditions necessary for home-dwelling older adults living with multiple chronic conditions (OAMCC) to be able to remain at home and preserve their quality of life. Currently, the reasons for
Armin von Gunten, Filipa Pereira, Pauline Roux, Marie Santiago-Delefosse, Boris Wernli, Maria Manuela Martins, Henk Verloo   +6 more
doaj   +1 more source