Results 41 to 50 of about 459,044 (312)

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Exploring the dynamics of compliance with community penalties [PDF]

, 2008
In this paper, we examine how compliance with community penalties has been theorized hitherto and seek to develop a new dynamic model of compliance with community penalties. This new model is developed by exploring some of the interfaces between existing
Ayres, Ian, Bottoms, Anthony, Braithwaite, Valerie, Ellis, Tom, Fergus McNeill, Gwen Robinson, Hawkins, Keith, Hearnden, Ian, Hedderman, Carol, Her Majesty's Inspectorate of Probation, Hirschi, Travis, Home Office, Home Office, Home Office, Home Office, Home Office, Hough, Mike, Hucklesby, Anthea, Kagan, Robert A., Kagan, Robert A., Kemshall, Hazel, Kemshall, Hazel, May, Chris, McBarnet, Doreen, McIvor, Gill, Morgan, Rod, Murphy, Kristina, Nellis, Mike, Power, Michael, Raynor, Peter, Raynor, Peter, Reiss, Albert J., Roberts, Colin, Robinson, Gwen, Scottish Executive, Sherman, Lawrence W., Social Work Inspection Agency, Social Work Inspection Agency, Tyler, Tom R., Tyler, Tom R.   +39 more
core   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

The Psychological Aspects of Virtual Office at Home for Employees and Employers During The COVID-19 Pandemic

Journal of Indonesian Economy and Business, 2022
Introduction/Main Objectives: The COVID-19 pandemic has made changes to all aspects of life. Work must be done at home or somewhere outside the office. Although a virtual office is mostly done from one’s home, it can be done anywhere.
Yuliana Yuliana
doaj   +1 more source

Increasing the voluntary and community sector’s involvement in Integrated Offender Management(IOM) [PDF]

, 2011
As part of an undertaking to increase voluntary and community sector (VCS) involvement in service delivery, the Home Office set up an initiative to provide small grants to VCS organisations to work with IOM partnerships.
Bird, Hayden, Davidson, Joanna, Meadows, Linda, O'Keeffe, Caroline, Senior, Paul, Wilkinson, Katherine, Wong, Kevin   +6 more
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Relationship between diversification of place of work and organizational commitment

Annals of Business Administrative Science
This study shows that a positive correlation exists between diversification of place of work and organizational commitment. The study compared the working-at-the-office group, working-from-home group, and shared-office-use group using data from an ...
Nobuyuki Inamizu
doaj   +1 more source

Within- and between-person changes in work practice and experiences due to COVID-19: Lessons learned from employees working from home, hybrid working, and working at the office

Frontiers in Psychology, 2022
IntroductionIn response to the requirement of keeping social distance during the COVID-19 outbreak a lot of employees needed to change from a regular office to a home-office at short notice.
Siw Tone Innstrand, Marit Christensen, Karoline Grødal, Cristina Banks   +3 more
doaj   +1 more source

Comparison of porcine thorax to gelatine blocks for wound [PDF]

, 2016
Published online first in International Journal of Legal Medicine. The support of EPSRC and The Home Office are recognised. Open Access, this article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http ...
Carr, D. J., Champion, Stephen M., Mabbott, A., Malbon, C.   +3 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source