Results 41 to 50 of about 454,869 (293)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Indirect Connection Analysis Based on Wave-system Structures of Airlines Architecture in Hub Airport

Journal of Aerospace Technology and Management, 2023
Slot resources are limited and not properly allocated, and the wave-system structures of airlines can organize slot time effectively. The article identifies and evaluates the wave-system structure of Beijing Daxing International Airport and Beijing ...
Zhou Xiang, Han Ruiling, Zhang Xiaoyan, Du Xiaohu   +3 more
doaj  

CONDIÇÕES DE TRABALHO E CUSTO HUMANO DO TRABALHO EM HOME-OFFICE EM TEMPOS DE PANDEMIA

Ação Ergonômica, 2020
A pandemia da COVID-19 fez com que muitas empresas tivessem que recorrer ao trabalho remoto em casa como alternativa para a realização das suas atividades, porém, a mudança brusca e sem o devido planejamento, repercutiu no aumento das demandas de ...
Rosemary Cavalcante Gonçalves, Karla Carneiro Romero Correia, Ricardo de Assis Lopes Andrade   +2 more
doaj   +1 more source

Increasing the voluntary and community sector’s involvement in Integrated Offender Management(IOM) [PDF]

, 2011
As part of an undertaking to increase voluntary and community sector (VCS) involvement in service delivery, the Home Office set up an initiative to provide small grants to VCS organisations to work with IOM partnerships.
Bird, Hayden, Davidson, Joanna, Meadows, Linda, O'Keeffe, Caroline, Senior, Paul, Wilkinson, Katherine, Wong, Kevin   +6 more
core  

Comparison of porcine thorax to gelatine blocks for wound [PDF]

, 2016
Published online first in International Journal of Legal Medicine. The support of EPSRC and The Home Office are recognised. Open Access, this article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http ...
Carr, D. J., Champion, Stephen M., Mabbott, A., Malbon, C.   +3 more
core   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

The Psychological Aspects of Virtual Office at Home for Employees and Employers During The COVID-19 Pandemic

Journal of Indonesian Economy and Business, 2022
Introduction/Main Objectives: The COVID-19 pandemic has made changes to all aspects of life. Work must be done at home or somewhere outside the office. Although a virtual office is mostly done from one’s home, it can be done anywhere.
Yuliana Yuliana
doaj   +1 more source

Immigration statistics: is the tanker turning around? [PDF]

, 2012
At last the Home Office has ‘good news’ to report on lower net migration figures. Don Flynn asks whether this is a measure of successful policies, or just a measure of how deep the economic mire we are all ...
Flynn, Don
core  

Dangerous drugs, dangerous mothers: Gender, responsibility and the problematisation of parental substance use [PDF]

, 2019
If, as many would have it, the ‘drugs problem’ is among the more perilous and uncompromising challenges of our times, parental substance misuse represents one of its most insidious expressions. The past 15 years has seen the ‘hidden harms’ experienced by
Advisory Council on the Misuse of Drugs (ACMD), Advisory Council on the Misuse of Drugs (ACMD), Bacchi C, Bacchi C, Berridge V, Berridge V, Bull M, Burman E, Cain R, Courtwright D, Critcher C, Donzelot J, Foucault M, Foucault M, Foucault M, Gillies V, Gutzke D, Home Office, Home Office, Home Office, Home Office, Home Office, Home Office, Lexmond J, Muncie J, Public Health England (PHE), Room R, Shaw A, Simon Flacks, Stevens A   +29 more
core   +1 more source