Results 71 to 80 of about 8,208,719 (301)

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

An Educational Pathway for Geriatric Home Caregivers [PDF]

, 2008
The establishment of a multi-tiered educational pathway for geriatric home caregivers would support efforts to meet the needs of an increasing number of community dwelling older adults who require assistance with activities of daily living, while ...
Beth C. Vaughan-Wrobel, Sherry White
core  

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Comparative Preclinical Evaluation of the Safety, Antifungal Activity, and Pharmacokinetics of Sertaconazole Products for External Use

Безопасность и риск фармакотерапии
SCIENTIFIC RELEVANCE. The high prevalence of fungal skin infections motivates expanding the range of sertaconazole products for external use.AIM.
V. M. Kosman, M. V. Karlina, V. A. Vavilova, K. E. Borovkova, K. L. Kryshen, N. V. Marchenko, S. A. Kopatko, I. V. Sychkova, D. R. Kargopoltseva, M. N. Makarova, V. G. Makarov   +10 more
doaj   +1 more source

Sanandaj Historic Houses; the Reading of Physicality from a Life Culture Point of View [PDF]

صفه, 2018
To achieve an accurate understanding of a certain architecture, one needs to equally focus on explicit and implicit aspects of it, and this, in turn, requires the study of both a building’s physicality and the life lived in it.
Azadeh Aghalatifi, Vahid Kolyaii
doaj  

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Assessment of functional safety of blood forming organs in research of toxicological properties of medicinal products (Review). Part 1. Features of the hematopoietic organs of laboratory animals. Mechanisms of hematotoxicity

Регуляторные исследования и экспертиза лекарственных средств
INTRODUCTION. The blood contains a large quantity of active cells of the organism and is a basic target for potentially toxic substances. The regulatory documents of the Russian Federation and international recommendations provide a list of mandatory ...
N. M. Faustova, A. E. Saloponova, M. V. Miroshnikov, M. N. Makarova, V. G. Makarov   +4 more
doaj   +1 more source

Size of Home, Home Ownership, and the Mortgage Interest Deduction [PDF]

, 2012
This paper offers an empirical test of the effect of the mortgage interest deduction (MID) on both the extensive (own vs. rent) and intensive (size of home) housing purchase margins.
Hanson, Andrew
core   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source