Results 41 to 50 of about 1,793,728 (267)

Interpretation of toxicological research data in establishing the no observed adverse effect level (NOAEL) for medicinal products

Регуляторные исследования и экспертиза лекарственных средств
INTRODUCTION. Toxicological studies of new pharmaceuticals in laboratory animals represent an obligatory stage in drug risk assessment, designed to identify toxic effects, their potential reversibility, and dependence on dose and/or systemic exposure ...
K. L. Kryshen, Ya. A. Gushchin, N. M. Faustova, S. V. Gushchina, Zh. Yu. Ustenko, A. E. Katelnikova, K. T. Sultanova, A. A. Matichin, V. A. Vavilova, Ya. G. Murazov, M. V. Miroshnikov, M. A. Kovaleva, D. V. Shubin, V. G. Makarov, M. N. Makarova   +14 more
doaj   +1 more source

Of Women, Wine and Salt: Revisioning the Home in Harriet Prescott Spofford’s Detective Fiction

European Journal of American Studies, 2019
Although Harriet Prescott Spofford appears to have given up the genre of detective fiction in the late 1860s, she actually used it as the foundation for works in which suspense, sudden revelations and unexpected final twists serve her investigation of ...
Stéphanie Durrans
doaj   +1 more source

From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care

Molecular Oncology, EarlyView.
Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard, Flavie Bénard, Eva Billat, Margaux Le Guyon, Victoria Maltret, Laura Merlet, Chloé Astrid Walter, Tony Avril, Eric Chevet   +8 more
wiley   +1 more source

Endoscopic stenting for malignant large-bowel obstruction as a management option for palliative patients in private medical practice: a case series and review of contemporary guidelines

Perioperative Medicine
Background. Malignant bowel obstruction is a frequent complication of colorectal cancer and is associated with high mortality, frequent stoma formation, and a marked deterioration in quality of life, especially in incurable patients.
Vitalii Rusakov, Svitlana Piriieva, Marko Chystiak, Dmytro Havrychenko, Ruslan Voloshyn, Serhii Semeniuk, Anzhelika Melnychenko, Kostiantyn Naumenko   +7 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

24 maalausta sekunnissa: Eino Ruutsalon taiteen uusi ulottuvuus 1960-luvun alussa

Tahiti, 2017
Artikkelissani haen vastausta kysymykseen, miksi Eino Ruutsalo (1921–2001) lopetti vuonna 1961 moneksi vuodeksi maalaamisen kankaalle ja ryhtyi maalaamaan filmille.
Marko Home
doaj  

Cardiovascular Safety Assessment of Medicines in Preclinical In vivo Studies: A Review

Безопасность и риск фармакотерапии
INTRODUCTION. The cardiovascular safety evaluation of medicines using in vivo models is a necessary preclinical step that is performed either in safety pharmacology studies or in toxicity studies.
K. T. Sultanova, M. V. Miroshnikov, A. Yu. Borodina, E. V. Simonova, Zh. Yu. Ustenko, E. V. Mazukina, K. L. Kryshen, A. A. Matichin, M. N. Makarova, V. G. Makarov   +9 more
doaj   +1 more source

Feeling at home in nursing homes [PDF]

Journal of Advanced Nursing, 2001
Feeling at home in nursing homes Aim. The purpose of this study was to examine determinants of feeling at home and in particular the privacy in nursing homes in The Netherlands. The first question was to what extent nursing homes differed in the degree residents feel at home and experience privacy.
A J, de Veer, A, Kerkstra
openaire   +2 more sources

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Home safe home [PDF]

Journal of Trauma and Acute Care Surgery, 2016
The London Health Sciences Centre Home Safety Program (HSP) provides safety devices, education, a safety video, and home safety checklist to all first-time parents for the reduction of childhood home injuries. The objective of this study was to evaluate the HSP for the prevention of home injuries in children up to 2 years of age.A program evaluation ...
Tanya Charyk, Stewart, Andrew, Clark, Jason, Gilliland, Michael R, Miller, Jane, Edwards, Tania, Haidar, Brandon, Batey, Kelly N, Vogt, Neil G, Parry, Douglas D, Fraser, Neil, Merritt   +10 more
openaire   +3 more sources