Results 81 to 90 of about 6,143,570 (254)

Mitochondria and Neuromast Tagging With Fluorescent Gallium‐Triapine Analogues: In Cellulo MP FLIM and Zebrafish Live Imaging

Advanced Science, EarlyView.
Fluorescent BODIPY‐conjugated thiosemicarbazone ligands and their Ga(III), In(III), and Fe(III) complexes, inspired by Triapine, are developed as theranostic agents. Multiphoton FLIM and confocal microscopy in cancer cells and zebrafish reveal real‐time uptake, mitochondrial localisation, and whilst spectroscopic assays indicated preserved complex ...
Megan J. Green, Michael W. Jones, Merissa Saleem, Haobo Ge, Melita Tvardauskaite, Julia Dudzic, Fernando Cortezon‐Tamarit, Rory L. Arrowsmith, Charareh Pourzand, Gabriele Kociock‐Kohn, Nicholas H. Rees, Jonathan R. Dilworth, Stephen Faulkner, Stanley W. Botchway, David Gurevich, Sofia I. Pascu   +15 more
wiley   +1 more source

Task force VI: Self-monitoring of the blood pressure.

, 1999
BACKGROUND: Self-monitoring of the blood pressure by patients at home or in other nonclinical settings has become increasingly common in recent years. This phenomenon has been fueled in part by the increase in availability of automatic sphygmomanometers,
Asmar, R., Thijs, L., Waeber, B., Mansoor, G.A., Padfield, P., Imai, Y., White, W.B.   +6 more
core   +1 more source

Comparison between an adapted protocol for home and ambulatory measurement for evaluating night-time blood pressure behaviour

Blood Pressure
Background The diagnosis and treatment of hypertension rely on the accuracy of blood pressure (BP) measurements obtained both in and out of the office during awake and sleep periods.Objective To evaluate whether a home blood pressure monitoring (HBPM ...
Thamyres Costa Borges, Priscila Valverde de Oliveira Vitorino, Sayuri Inuzuka, Ana Luiza Lima Sousa, Moisés Martins de Oliveira, Carlos Augusto Pícoli de Andrade, Rodrigo Bezerra, Audes Diógenes Magalhães Feitosa, Weimar Kunz Sebba Barroso   +8 more
doaj   +1 more source

Disrupted TFEB/GDNF–cAMP/ATP Coupling Underlies Astrocytic Dysfunction and Depression in LRRK2 G2019S Parkinson's Mice

Advanced Science, EarlyView.
ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao, Maryam Hatami, Sumeyye Koc, Qing Jiang, Thomas Skutella, Yuanfeng Zhang   +5 more
wiley   +1 more source

The Mind From Within: Visceral Roots of Human Cognition

Advanced Science, EarlyView.
The physiological activity of visceral organs, such as the heart, the lungs, and the gut, is surprisingly linked to many sophisticated mental operations, such as remembering the past, being aware of ourselves, making choices, and forging social bonds.
Alessandro Monti, Salvatore Maria Aglioti   +1 more
wiley   +1 more source

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

Multidimensional and Multifunctional Laser‐Induced Graphene (LIG) for Point‐of‐Care and Wearable Biosensing, Theranostics, and Bioactive Interfaces Toward Personalized Healthcare and Regenerative Medicine

Advanced Science, EarlyView.
Multidimensional laser‐induced graphene (LIG) spanning from 0D to 3D architectures is comprehensively reviewed for multifunctional biomedical platforms, including biosensing, theranostics, and bioactive interface applications, which highlights its potentials for point‐of‐care diagnostics, wearable health monitoring, smart drug delivery, and tissue ...
Li Zhang, Yurou Yuan, Xiaohong Ding, Wing Cheung Mak   +3 more
wiley   +1 more source

Dietary Protein and Blood Pressure: A Systematic Review [PDF]

, 2010
Background - Elevated blood pressure (BP), which is a major risk factor for cardiovascular disease, is highly prevalent worldwide. Recently, interest has grown in the role of dietary protein in human BP.
Wieke Altorf-van der Kuil, Bakker, S.J.L., Bakker, Stephan J. L., Navis, G., Johanna M Geleijnse, Geleijnse, J.M., Baak, M.A. van, Geleijnse Johanna M., Kuil, W.A. van der, Bakker Stephan J. L., van't Veer, Pieter, Bakker, Stephan J. L.; id_orcid, Marleen A van Baak, Geleijnse, Johanna M., Mariëlle F Engberink, van Baak, M.A., Mariëlle F. Engberink, Engberink, Marielle F., Stephan J L Bakker, Altorf-van der Kuil, Wieke, van Baak Marleen A., Pieter van 't Veer, Brink, Elizabeth J., Wieke Altorf – van der Kuil, Bakker, S.J., van Baak, Marleen A., Johanna M. Geleijnse, Brink Elizabeth J., Veer, P., van 't, Engberink Mariëlle F., Brink, E.J., van 't Veer Pieter, Veer, P. van't, Gerjan Navis, van 't Veer, P., Marleen A. van Baak, Navis, Gerjan, Elizabeth J. Brink, Engberink, M.F., Stephan J. L. Bakker, van der Kuil, W., Navis Gerjan, Altorf-van der Kuil, W., Baak, M.A., van, Elizabeth J Brink, Altorf, W., Altorf – van der Kuil Wieke   +46 more
core   +3 more sources

Hyperpolarization of [1‐13C]Ketoisocaproate‐d2 by Reversible Exchange with Parahydrogen Enables Profiling of Branched‐Chain‐Amino‐Acid Metabolism in Cellulo and in Vivo

Advanced Science, EarlyView.
We report the fast generation of biocompatible solutions of highly 13C‐hyperpolarized (≈11%) partially‐deuterated ketoisocaproate within <6 min using spin‐lock‐induced crossing and reversible exchange with parahydrogen (SLIC‐SABRE). This enables rapid detection of branched‐chain‐amino‐acid transferase 1 (BCAT1) protein expression and investigation of ...
Stefan Petersen, Philipp R. Groß, Paul M. Schmidt, Henri de Maissin, Asitan Rittinger, Robert Willing, Adriana Sacristán‐Martín, Lisa Heß, Jule Koch, Sebastian Lucas, Maxim Zaitsev, Dominik von Elverfeldt, Martin Grashei, Franz Schilling, Jan‐Bernd Hövener, André F. Martins, Max von Delius, Thomas Reinheckel, Andreas B. Schmidt   +18 more
wiley   +1 more source

Blood pressure measurement – an overview

Swiss Medical Weekly, 2012
Arterial hypertension continues to represent the leading cause of morbidity and mortality world-wide. Diagnosis and therapy of arterial hypertension require adequate blood pressure measurements.
Thomas Dieterle
doaj   +1 more source