Results 41 to 50 of about 2,384,974 (349)

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Home based primary care services in Singapore

International Journal of Integrated Care, 2019
Introduction: In the World Report on Ageing and Health, the World Health Organisation (WHO) described the type of health care needed for ageing populations as “integrated health care for older people”.
Stephanie Q Ko, Serene Wong
doaj   +1 more source

Incremental Cost Estimates for the Patient-Centered Medical Home [PDF]

, 2009
Based on data from thirty-five primary care practices, analyzes the costs associated with the medical home model, in which primary care practices also provide care coordination, patient education, and related services.
Aimee Williams, David Gans, Katie Merrell, Robert A. Berenson, Shari Erickson, Stephen Zuckerman, Terry Hammons, William Underwood   +7 more
core  

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

MOUD 2.0: a clinical algorithm and implementation evaluation protocol for sublingual and injectable buprenorphine treatment of opioid use disorder

Frontiers in Psychiatry
BackgroundPrimary care is the initial contact point for most patients with opioid use disorder (OUD) but lacks tools for guiding treatment. Only a small fraction of patients access evidence-based care.
Brandon L. Joa, Eric N. Fung, Michael S. Weinstein, Lara C. Weinstein, Lara C. Weinstein   +4 more
doaj   +1 more source

Relationship between home care service use and changes in the care needs level of Japanese elderly

BMC Geriatrics, 2009
Background With the introduction of long-term care insurance (LTCI) in Japan, more home care services are available for the community-dwelling elderly. To deliver effective home care services, it is important to know the effects of service use.
Sato Mikiya, Kashiwagi Masayo, Tamiya Nanako, Kato Gohei, Takahashi Hideto   +4 more
doaj   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Investigation of Home Health Services and Expectations of Patients and Patient Relatives: A Study Case in Bakirkoy District

İstanbul Gelişim Üniversitesi Sağlık Bilimleri Dergisi, 2020
Aim: The aim of this study is to examine the expectations and demands of patients and their relatives' in-home health care. In the scope of the study, narrow area as the study was being carried out in the Bakirkoy district of Istanbul province.Method: In
Gülay Tamer
doaj   +1 more source

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

FEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

Home care services as a possibility to express art, creativity and access to technology

Online Brazilian Journal of Nursing, 2008
This study is a reflection about art, creativity and technologies applied to nursing, within the process of contemporary care, particularly about the home care user and in the light on integral care.
Janice de Moraes Blois, Maria do Horto Fontoura Cartana, Grace T.M. Dal Sasso, Cleusa Rios Martins   +3 more
doaj   +2 more sources