Results 131 to 140 of about 1,925,354 (375)

Development of Dimethylsulfonium Probes for Broad Profiling of Methyllysine Reader Proteins

Advanced Science, EarlyView.
Development of oligoglycine‐based dimethylsulfonium probes for unbiased crosslinking to methyllysine readers. The general probe facilitates profiling of site‐specific methyllysine readers, evaluation of selectivity and activity of reader inhibitors, and global profiling of methyllysine readers.
Jinyu Yang, Yihang Xiao, Yingxiao Gao, Mingxuan Wu   +3 more
wiley   +1 more source

Barnes Hospital Bulletin [PDF]

, 1969
https://digitalcommons.wustl.edu/bjc_barnes_bulletin/1026/thumbnail ...

core   +4 more sources

An Environmental Scan and Evaluation of Home Dialysis Quality Indicators Currently Used in Canada

Canadian Journal of Kidney Health and Disease, 2020
Background: Quality indicators are important tools to measure and ultimately improve the quality of care provided. Performance measurement may be particularly helpful to grow disciplines that are underutilized and cost-effective, such as home dialysis ...
Lisa Dubrofsky, Ali Ibrahim, Karthik Tennankore, Krishna Poinen, Sachin Shah, Samuel A. Silver   +5 more
doaj   +1 more source

Multidisciplinary teams, and parents, negotiating common ground in shared-care of children with long-term conditions: A mixed methods study [PDF]

, 2013
Background: Limited negotiation around care decisions is believed to undermine collaborative working between parents of children with long-term conditions and professionals, but there is little evidence of how they actually negotiate their respective ...
A Lindsay Waters, A Tong, A Tong, B Bechky, B Carter, B Warady, BRS: The Renal Team, D Ward, Davina Allen, DOH, DoH/DfES, E Nolte, E Wenger, F Dobbel, F Wells, H Feldman, H Feveile, H Lambert, Heather Lambert, J Ritchie, JES Scott, JK Hovey, Julian Williams, K Knafl, K Knafl, K O’Reilly, KA Knafl, L Shields, Laura Crowther, Leila Qizalbash, Lucy Wirz, M Lewis, M Polanyi, M Saks, MD Sinha, ME Duffy, MG Coulthard, MRC, Nicholas JA Webb, R Morton, Ruth Nightingale, S Ajarmeh, S Goldstein, S Menon, Trish Smith, V Hayes, V Swallow, V Swallow, V Swallow, V Swallow, V Swallow, V Swallow, V Swallow, V Swallow, Veronica M Swallow, VM Swallow   +55 more
core   +3 more sources

Biomimetic Nanomedicine for Senescence‐Modulated Immune Activation Enhances Immunotherapy Efficacy in Hepatocellular Carcinoma

Advanced Science, EarlyView.
A multifunctional mPDZM nanoplatform is developed in this study. mPDZM integrates chemotherapy‐induced senescence, selective senolysis, and STING‐mediated immune activation. mPDZM effectively clears senescent tumor cells, remodels the tumor immune microenvironment, and enhances antitumor T‐cell responses.
Shiji Fang, Liyun Zheng, Bin Lin, Jiale Chen, Dehai Hou, Yiming Ding, Mengzhu Han, Pan Qin, Mengyuan Wang, Xiaoju Guo, Yeyu Zhang, Gaofeng Shu, Fazong Wu, Jianfei Tu, Minjiang Chen, Zhongwei Zhao, Zhuang Liu, Jiansong Ji   +17 more
wiley   +1 more source

Rod‐Shaped Nanotherapeutics Alleviate Rheumatoid Arthritis by Precisely Disrupting Platelet‐Mediated Pathological Crosstalk via a Morphology‐Dependent Manner

Advanced Science, EarlyView.
Owing to the margination effect, rod‐shaped nanoparticles exhibit markedly enhanced co‐localization with endothelial‐adherent platelets (PLTs) under dynamic blood flow. When internalized by PLTs, rod‐shaped PNR@Res inhibit FAK and PI3K/AKT signaling in a morphology‐dependent manner, thereby disrupting their pathological crosstalk with various ...
Bin Zhang, Yuanyi Hua, Xin Wen, Zhumei Liao, Jianheng Ren, Yajun Weng, Qin Wang   +6 more
wiley   +1 more source

A thematic synthesis of the experiences of adults living with hemodialysis [PDF]

, 2016
Background and objectives In-center dialysis patients spend significant amounts of time on the dialysis unit; additionally managing ESKD affects many aspects of life outside the dialysis unit.
Jones, Colin, Reid, Claire, Seymour, Julie   +2 more
core   +1 more source

Competition Between Liquid‐Liquid Crystalline Phase Separation (LLCPS) and Liquid‐Liquid Phase Separation (LLPS) in Amyloid Fibril Colloidal Systems

Advanced Science, EarlyView.
This study shows that amyloid fibrils form nematic condensates via liquid–liquid crystalline phase separation (LLCPS). With increasing pH, this transition shifts toward disordered condensates formed through liquid–liquid phase separation (LLPS), in which birefringence with lack of a coherent nematic field symmetry originates from enthalpic fibril ...
Milad Radiom, Raffaele Mezzenga
wiley   +1 more source

Uptake of home dialysis in younger adults: case studies that illustrate the multifaceted influence of home circumstances on dialysis decisions

Clinical Case Reports, 2017
Key Clinical Message Younger adults considering home dialysis need support to ensure home circumstances are suitable and affordable. Home circumstances relate closely to the financial burden reported by younger home dialysis users.
Louise Collingridge, Keri‐Lu Equinox, Serena Frasca, Rosemary Simmonds, Melinda Tomlins, Josephine Chow   +5 more
doaj   +1 more source

Trojan Horse Strategy: How Biomimetic Nanomedicine Remodels the Tumor Microenvironment

Advanced Science, EarlyView.
This review focuses on biomimetic nanomedicines for tumor microenvironment (TME) remodeling, covering their diverse biomimetic types, design principles, and mechanisms of immune cell reprogramming and reversal of immunosuppressive microenvironments, with particular emphasis on their application in synergistic immunotherapy.
Wanrong Wang, Siqi Mu, Juan Zhang, Guisong Shan, Xueqian Li, Ran Wang, Tao Guo, Xiaoyan He   +7 more
wiley   +1 more source