Results 201 to 210 of about 139,310,016 (257)

Gene Correction Enhances Dopaminergic Cell Therapy in a Nonhuman Primate Model of Parkinson's Disease

Advanced Science, EarlyView.
LRRK2‐mutant induced pluripotent stem cells (iPSCs) were derived from a patient with Parkinson's disease (PD). Using CRISPR/Cas9–mediated gene editing, the pathogenic LRRK2 mutations were precisely corrected, and isogenic dopaminergic neural progenitor cells (DA‐NPCs) were subsequently generated.
Qing Yan, Chongchong Xu, Jiangmei Gao, Pu Wang, Qingling Wu, Ying Jin, Binyan Lu, Mu Li, Mingting Shao, Bihai Li, Zhenghui Su, Yijng Zhang, Jianhuan Chen, Haojie An, Mengyao Huang, Xiaoji Zhuang, Yuhui Shen, Fenglin Wang, Nana Xu, Yiyan Liu, Lei Tang, Xiuling Zhong, Minyan Zhong, Jiecong Chen, Zhenhuang Wang, Xingrong Luo, Sheng Liu, RuiFeng Liu, Ling Zhang, Junhua Rao   +29 more
wiley   +1 more source

HABIT-ILE@home for Children With Bilateral Cerebral Palsy: Protocol for Noninferiority and Superiority Randomized Controlled Trials. [PDF]

JMIR Res Protoc
Rosselli Z, Somville M, Ducoffre E, Arnould C, Bleyenheuft Y, Saussez G.   +5 more
europepmc   +1 more source

A Printed Hydrogel Hybrid Electronic System With Thermoresponsive Adhesion for Neurophysiological Monitoring

Advanced Science, EarlyView.
This work develops a soft hybrid electronic system with printed thermoresponsive hydrogel electrodes, which enables high‐fidelity neural signal acquisition and stimulation. The system precisely assesses median and ulnar nerve injuries in clinical cases, realizing accurate diagnosis of neural impairment while ensuring customized adhesion regulation ...
Bo Pang, Ganguang Yang, Jiacheng Wen, Hangyu Gong, Caixin Gong, Yuqi Qiu, Zhixin Wang, Qingyang Zheng, Sen Zhou, Tianzhao Bu, Jia Tian, Zhouping Yin, Yutian Liu, Hao Wu   +13 more
wiley   +1 more source

Historical Changes and Cross-Country Comparisons of Long-Term Care Policy: A New Resource. [PDF]

J Long Term Care
Knapp D, Lee Y, Fransz-Myers M, Pasini G.   +3 more
europepmc   +1 more source

Psychological Stress Associated Bile Acid Reprogramming Promotes Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
Depression is increasingly recognized as a risk factor for chronic diseases, yet its biological impact on cancer remains unclear. Using data from more than 490 000 participants across three international cohorts, we show that depression significantly increases the risk of liver cancer.
Ruijiang Zeng, Mengmeng Wang, Kang Wang, Zhuo Xing, Yulong Hong, Tongtong Li, Geng Zong, Chong Yang, Dan Zhang, Zhangling Chen, Xin Jin   +10 more
wiley   +1 more source

Can Intelligent Monitoring Help Older Adults Live Safely at Home Longer? [PDF]

J Med Internet Res
Congdon J.
europepmc   +1 more source

Enhancing All‐Solid‐State Batteries Performance Through Thickness Control and Surface Passivation of Thermally Evaporated Lithium Metal Anodes

Advanced Science, EarlyView.
This study demonstrates that thermally evaporated lithium anodes combined with LiF passivation provide a high‐performance thin anode design for next‐generation ASSBs. This approach increases the critical current density from 1.6 to 2.6 mA cm−2, enabling full cells to achieve over 500 and 300 cycles at 1.5 and 3 mA cm−2, respectively, outperforming even
Jinsong Zhang, Linfeng Xu, Robin N. Wullich, Thomas J. Schmidt, Mario El Kazzi   +4 more
wiley   +1 more source

Socioeconomic differentials in multimorbidity prevalence, health and social care expenditure among persons 65 years and older in region Stockholm, Sweden: a population-based study. [PDF]

BMJ Open
Doheny M, Burström B, Agerholm J, Liljas A.   +3 more
europepmc   +1 more source

Biomimetic Gradient Hydrogels Regulate Osteochondral Regeneration Microenvironment Remodeling via Spatiotemporal Programming Engineering

Advanced Science, EarlyView.
Electric field‑driven continuous gradient hydrogel GHZF4 achieves spatiotemporal growth factor release, modulates immune microenvironment, angiogenesis and osteochondral differentiation. It realizes cell‑free functional osteochondral repair in rat/rabbit models, offering a promising biomimetic strategy for gradient tissue regeneration.
Xiaolian Niu, Shengzhao Xiao, Di Huang, Xuesong Wang, Yanwei Cao, Xiaodan Sun, Nicholas Dunne, Xiaoming Li   +7 more
wiley   +1 more source

Individual and Institutional Factors Associated With the Quality of Life of Portuguese Older Adults Living in Nursing Homes. [PDF]

Psychogeriatrics
Alves B, Gonçalves M, Costa AR, Passadouro R, Lopes A, Henriques A.   +5 more
europepmc   +1 more source