Results 41 to 50 of about 139,310,016 (257)

Time trends in general practitioners’ home visits for older patients: a retrospective cross-sectional study from Switzerland

Swiss Medical Weekly, 2021
WHAT IS KNOWN ON THE SUBJECT, AND WHAT THE STUDY ADDS: The number of home visits by general practitioners (GPs) has decreased in recent years, in contrast to the increasing number of frail and older patients in western countries.
Stefan Neuner-Jehle, Sereina M. Graber, Ellen Keizer, Carola A. Huber, Eva Blozik, Thomas Rosemann, Oliver Senn   +6 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Calibrating limitation features and dependence levels in basic activities of daily living among individuals with dementia: an item response theory-based analysis

BMC Geriatrics
Background Evaluating basic activities of daily living (BADL) is essential for monitoring disease progression and determining appropriate care plans for individuals with dementia.
Jinni Wang, Xiangyi Chen, Xiaomei Lin, Hua Ye, Xiaoyan Liao   +4 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Mental health status of children who use foreign languages at home in Japan

PCN Reports, 2023
Aim Little is known about the mental health status of children in Japan whose roots are in foreign countries. The differences in language that are used every day may be a factor that makes adaptation difficult for these children.
Michio Takahashi, Tomoko Nishimura, Yuko Osuka, Nobuaki Tsukui, Masaki Adachi, Taiichi Katayama, Manabu Wakuta   +6 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Serviços de atenção ao idoso e estratégias de cuidado domiciliares e institucionais

Revista Brasileira de Geriatria e Gerontologia
INTRODUÇÃO: As redes de atenção à saúde são fundamentais para assistir a população idosa em seus diversos aspectos. A assistência domiciliar, o Programa Acompanhante de Idosos da Secretaria Municipal da Saúde da cidade de São Paulo e as instituições de ...
Fernanda Pretti Chalet Ferreira, Luciana Orui Bansi, Sérgio Márcio Pacheco Paschoal   +2 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Construction of a Hospice Service Model for Elderly Care Institutions in China [PDF]

Zhongguo quanke yixue
Background With the acceleration of the aging process in society, the demand for hospice services is increasing. The development of hospice care in China started relatively late, and relevant institutional construction standards and management norms are ...
WANG Huaping, ZHU Huajie, ZHU Chunman, PAN Danhong
doaj   +1 more source