Results 61 to 70 of about 13,506,505 (289)

Current perspectives on pharmacist home visits: do we keep reinventing the wheel?

Integrated Pharmacy Research and Practice, 2018
Priti S Flanagan,1,2 Andrea Barns1 1Pharmacy Community Programs, Lower Mainland Pharmacy Services, Langley, BC, Canada; 2Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada Abstract: The scope of clinical pharmacy ...
Flanagan PS, Barns A
doaj  

The Thinginess of Medications: Some Points of Observation From the Design Angle

DIID, 2022
A large number of healthcare studies are paying great attention to patients’ behaviour with medicines and to patient-related factors leading to successful or poor medication adherence.
Silvia Pizzocaro, Antonella Penati
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Medication Management Using Technology-Based Interventions in Older People at Home Care Settings: Protocol for a Scoping Review

JMIR Research Protocols
BackgroundOlder adults with complex care needs and polypharmacy are at risk of experiencing medication-related problems such as administration errors and adverse drug events. These problems lead to increased use of emergency care and hospital admissions.
Shiji Thomas, Beth Fylan, Jonathan Silcock, Md Shafiqur Rahman Jabin   +3 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Coordinating resources for prospective medication risk management of older home care clients in primary care: procedure development and RCT study design for demonstrating its effectiveness

BMC Geriatrics, 2018
Background The magnitude of safety risks related to medications of the older adults has been evidenced by numerous studies, but less is known of how to manage and prevent these risks in different health care settings.
Terhi Toivo, Maarit Dimitrow, Juha Puustinen, Eeva Savela, Katariina Pelkonen, Valtteri Kiuru, Tuula Suominen, Sirkka Kinnunen, Mira Uunimäki, Sirkka-Liisa Kivelä, Saija Leikola, Marja Airaksinen   +11 more
doaj   +1 more source

Use of preventive medication and supplements in general practice in patients in their last year of life: a Retrospective cohort study

BMC Primary Care, 2023
Background Several preventive medications and supplements become inappropriate in the last phase of life due to increased risk of adverse events caused by changed pharmacokinetics, drug-drug interactions, and changed care goals.
Anne Antonisse, Frederieke H. van der Baan, Matthew Grant, Gon Uyttewaal, Cathelijne Verboeket, Hanneke Smits-Pelser, Saskia C. C. M. Teunissen, Eric C. T. Geijteman   +7 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Integrating proven falls prevention interventions into government programs

Australian and New Zealand Journal of Public Health, 2014
Objective: To identify Department of Health programs with high potential to integrate evidence‐based interventions to prevent falls among older people. Methods: Broad consultation within the Department followed by structured decision making.
Lesley Day, Alex Donaldson, Catherine Thompson, Margaret Thomas   +3 more
doaj   +1 more source