Results 311 to 320 of about 360,376 (378)
E3 ligase Praja1 mediates ubiquitination and degradation of microtubule‐associated protein tau
E3 ligase Praja1, but not its paralogue Praja2, recognizes and ubiquitinates tau protein for proteasomal degradation. This newly identified function of Praja1‐mediated tau degradation suggests its role in protein quality control, which may provide insights into the pathogenesis of tauopathies.
Shiho Aoki +8 more
wiley +1 more source
Zebrafish Tgds, when expressed as a recombinant protein, catalyzes the dehydration of UDP‐D‐glucose, the initial step in the formation of 6‐deoxyhexoses. Corresponding Tgds mutations found in Catel–Manzke syndrome patients lead to reduced enzymatic activity and stability.
Maria Rosaria Coppola +11 more
wiley +1 more source
3′UTR variants of ALS‐linked RNAs modify subcellular and cellular phenotypes
Our study demonstrates that alternative 3′UTR variants of ALS‐linked transcripts modulate subcellular RNA localization and cytoskeletal architecture. NEFH 3′UTR‐Long promotes nuclear RNA clustering, while SOD1 3′UTR‐Long reduces filopodia formation. These results suggest that 3′UTRs, independent of coding sequences, can influence neuronal phenotypes ...
Melis Savasan‐Sogut +2 more
wiley +1 more source
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TDR: The Drama Review, 2020
Inspired by Elizabeth Kolbert’s The Sixth Extinction: An Unnatural History, the short play Homo Sapiens humorously explores whether Homo sapiens caused their own demise or managed to evolve into a new, more enlightened species.
C. Bilodeau
openaire +2 more sources
Inspired by Elizabeth Kolbert’s The Sixth Extinction: An Unnatural History, the short play Homo Sapiens humorously explores whether Homo sapiens caused their own demise or managed to evolve into a new, more enlightened species.
C. Bilodeau
openaire +2 more sources
Apidima Cave fossils provide earliest evidence of Homo sapiens in Eurasia
Nature, 2019Katerina Harvati +2 more
exaly +2 more sources
New fossils from Jebel Irhoud, Morocco and the pan-African origin of Homo sapiens
Nature, 2017Jean-Jacques Hublin +2 more
exaly +2 more sources

