Results 91 to 100 of about 3,202,238 (369)
FEBS Letters, EarlyView.Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile +8 more
wiley +1 more source
Automated in Silico Design of Homogeneous Catalysts
, 2020 Catalyst discovery is increasingly relying on computational chemistry, and many of the computational tools are currently being automated.
Marco Foscato, Vidar R. Jensen
semanticscholar +1 more source
Affine curvature homogeneous 3-dimensional Lorentz Manifolds
, 2005 We study a family of 3-dimensional Lorentz manifolds. Some members of the family are 0-curvature homogeneous, 1-affine curvature homogeneous, but not 1-curvature homogeneous. Some are 1-curvature homogeneous but not 2-curvature homogeneous.
Gilkey, P., Nikcevic, S.
core +2 more sources
Structural dynamics of the plant hormone receptor ETR1 in a native‐like membrane environment
FEBS Letters, EarlyView.The present study unveils the structural and signaling dynamics of ETR1, a key plant ethylene receptor. Using an optimized nanodisc system and solution NMR, we captured full‐length ETR1 in a native‐like membrane environment. Our findings reveal dynamic domain uncoupling and Cu(I)‐induced rigidification, providing the first evidence of metal‐triggered ...
Moritz Lemke +2 more
wiley +1 more source
Landscape of BRAF transcript variants in human cancer
Molecular Oncology, EarlyView.We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda +5 more
wiley +1 more source
>k-homogeneous infinite graphs
, 2017 In this article we give an explicit classification for the countably infinite graphs $\mathcal{G}$ which are, for some $k$, $\geq$$ k$-homogeneous. It turns out that a $\geq$$k-$homogeneous graph $\mathcal{M}$ is non-homogeneous if and only if it is ...
Ahlman, Ove
core +1 more source
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Distributed energy efficient unequal clustering algorithm for wireless sensor networks
Tongxin xuebao, 2009 A distributed energy-efficient unequal clustering （DEEUC） algorithm was proposed for wireless sensor net-works by research current routing algorithms. The core of DEEUC has three parts. Firstly, when tentative clusterheads are selected, an average energy
SHANG Feng-jun1 +2 more
doaj
Molecular Oncology, EarlyView.Cotargeting EGFR and STAT3 with Erlotinib and TTI‐101 impairs both 2D and 3D growth of ETV1‐overexpressing prostate cancer cells by disrupting a self‐sustaining ETV1–EGFR positive feedback loop that promotes EGFR and STAT3 expression and phosphorylation (activation).
Elsa Gomes Paiva +5 more
wiley +1 more source
Homogeneous state feedback stabilization of homogeneous systems [PDF]
Proceedings of the 39th IEEE Conference on Decision and Control (Cat. No.00CH37187), 2000 We show that for any asymptotically controllable homogeneous system in euclidian space (not necessarily Lipschitz at the origin) there exists a homogeneous control Lyapunov function and a homogeneous, possibly discontinuous state feedback law stabilizing the corresponding sampled closed loop system.
openaire +3 more sources