Results 41 to 50 of about 183,847 (315)

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

FEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino, Meijie Li, Cécile Fizames, Mattia Adamo, Laurence Lejay, Christian Dubos, Matthieu Platre, Antoine Martin   +7 more
wiley   +1 more source

A Classification of Compact Cohomogeneity One Locally Conformal Kähler Manifolds

Mathematics
In this paper, we apply a result of the classification of a compact cohomogeneity one Riemannian manifold with a compact Lie group G to obtain a classification of compact cohomogeneity one locally conformal Kähler manifolds.
Daniel Guan
doaj   +1 more source

Diameters of Homogeneous Spaces [PDF]

Mathematical Research Letters, 2003
Let G be a compact connected Lie group with trivial center. Using the action of G on its Lie algebra, we define an operator norm | |_{G} which induces a bi-invariant metric d_G(x,y)=|Ad(yx^{-1})|_{G} on G. We prove the existence of a constant \approx .12 (independent of G) such that for any closed subgroup H \subsetneq G, the diameter of the quotient
Freedman, Michael H., Kitaev, Alexei, Lurie, Jacob   +2 more
openaire   +3 more sources

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Noncommutative spaces of worldlines

Physics Letters B, 2019
The space of time-like geodesics on Minkowski spacetime is constructed as a coset space of the Poincaré group in (3+1) dimensions with respect to the stabilizer of a worldline.
Angel Ballesteros, Ivan Gutierrez-Sagredo, Francisco J. Herranz   +2 more
doaj   +1 more source

On the Geometry of Three-dimensional Pseudo-Riemannian Homogeneous Spaces. II [PDF]

Известия Саратовского университета. Новая серия: Математика. Механика. Информатика, 2020
The problem of establishing links between the curvature and the topological structure of a manifold is one of the important problems of the geometry. In general, the purpose of the research of manifolds of various types is rather complicated.
Mozhey, Natal’ya Pavlovna
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Boundedness of homogeneous fractional integral operator on Morrey space

Journal of Inequalities and Applications, 2016
For 0 < α < n ...
Siying Meng, Yanping Chen
doaj   +1 more source