Results 111 to 120 of about 1,769,411 (334)

Evaluation of trends in derived snowfall and rainfall across Eurasia and linkages with discharge to the Arctic Ocean [PDF]

open access: yes, 2006
To more fully understand the role of precipitation in observed increases in freshwater discharge to the Arctic Ocean, data from a new archive of bias-adjusted precipitation records for the former USSR (TD9813), along with the CRU and Willmott-Matsuura ...
Frolking, Steve   +6 more
core   +2 more sources

Versatile CRISPR‐Cas Tools for Gene Regulation in Zebrafish via an Enhanced Q Binary System

open access: yesAdvanced Science, EarlyView.
This study introduces CRISPR‐Q, a transgenic CRISPR‐Cas system leveraging the QFvpr/QUAS binary expression platform in zebrafish. CRISPR‐Q overcomes previous challenges in achieving stable and efficient gene regulation. By enabling precise spatiotemporal control of transcript knockdown (CRISPR‐QKD) and gene activation (CRISPR‐Qa), it provides a ...
Miaoyuan Shi   +13 more
wiley   +1 more source

Towards implementing climate services in Peru – The project CLIMANDES

open access: yesClimate Services, 2016
CLIMANDES is a pilot twinning project between the National Weather Services of Peru and Switzerland (SENAMHI and MeteoSwiss), developed within the Global Framework for Climate Services of the World Meteorological Organization (WMO). Split in two modules,
G. Rosas   +23 more
doaj   +1 more source

The Mitochondrial Guardian α‐Amyrin Mitigates Alzheimer's Disease Pathology via Modulation of the DLK‐SARM1‐ULK1 Axis

open access: yesAdvanced Science, EarlyView.
Dietary habits play a key role in chronic diseases, and higher annual consumption of fruit and vegetable may lower risk of dementia. Artificial intelligence predicts the lipid‐like compound α‐Amyrin (αA) from plants with edible peels as a drug candidate against Alzheimer's disease.
Shu‐Qin Cao   +36 more
wiley   +1 more source

Dry and wet periods in the northwestern Maghreb for present day and future climate conditions

open access: yesMeteorologische Zeitschrift, 2008
One urgent issue of climate research is the regional downscaling of global-scale climate scenarios. The present study, which is part of the research of the IMPETUS West-Africa project, shows an analysis of wet and dry periods in north-western Africa both
Kai Born, Andreas H. Fink, Heiko Paeth
doaj   +1 more source

The Stratospheric Water and Ozone Satellite Homogenized (SWOOSH) database: A long-term database for climate studies [PDF]

open access: gold, 2016
Sean Davis   +8 more
openalex   +2 more sources

International ethics and globalization [PDF]

open access: yes, 2011
In the inherently anarchic international system the validity of moral principles is weakening. To overcome anarchy global governance is needed. It means efficient international institutions, but also pressures from the global civil society and the self ...
Boda, Zsolt
core  

MicroRNA‐375‐3p Targets Fatty Acid Synthase and Relish to Regulate Energy Allocation During Pupal Metamorphosis and Starvation

open access: yesAdvanced Science, EarlyView.
During pupal metamorphosis and starvation, elevated 20‐hydroxyecdysone (20E) and suppressed insulin trigger Forkhead box O (FOXO) nuclear translocation, enhancing miR‐375‐3p expression. This downregulates fatty acid synthase (FASN) and Relish, promoting lipid breakdown for energy while prioritizing antioxidant responses over immune functions to support
Peng Chen   +10 more
wiley   +1 more source

SR‐B1‐Mediated Transplacental Transfer of Hydrophobic Toxicants Disrupts Fetal Development During Barriergenesis

open access: yesAdvanced Science, EarlyView.
This study maps the spatiotemporal distribution of hydrophobic toxicants and endogenous metabolites in the developing placenta and fetus. By integrating mass spectrometry imaging with snRNA‐seq, we identify SR‐B1 as a key transporter driving early‐gestation xenobiotic transfer and reveal a critical exposure window associated with persistent fetal ...
Yixuan Huang   +10 more
wiley   +1 more source

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