Results 141 to 150 of about 1,769,411 (334)

Nanotherapeutic Macrophage‐Neuro Reprogramming Through Immunometabolic Crosstalk Mitigates Sepsis‐Induced Lung Injury and Neurologic Damage

Advanced Science, EarlyView.
SJNPs co‐deliver JHU083 and spermine to reprogram macrophage–neuron immunometabolic crosstalk in sepsis. By suppressing pro‐inflammatory M1 polarization and promoting NGF‐mediated neurotrophic signaling, SJNPs preserve pulmonary neuronal integrity, alleviate lung injury, and improve survival in murine sepsis models.
Wenhui Wang, Yongrui Hai, Xintong Lu, Ye Chen, Bingjie Zhang, Renming Fan, Jiarui Dou, Jiaxin Yan, Shuo Fu, Wen Zhang, Junke Song, Gaofei Wei   +11 more
wiley   +1 more source

Homogenization of the Long Instrumental Daily-Temperature Series in Padua, Italy (1725–2023)

Climate
The Padua temperature series is one of the longest in the world, as daily observations started in 1725 and have continued almost unbroken to the present. Previous works recovered readings from the original logs, and digitalized and corrected observations
Claudio Stefanini, F. Becherini, Antonio della Valle, Dario Camuffo   +3 more
semanticscholar   +1 more source

H2S‐Releasing Aspirin Nanoparticles Alleviate Endometriosis and Associated Anxiety

Advanced Science, EarlyView.
Albumin nanoparticles loaded with an H2S‐releasing aspirin derivative (ACS14) hitchhiking neutrophils after intraperitoneal injection and preferentially accumulate in endometriosis lesions in mice. The treatment suppresses lesion growth by regulating PI3K/Akt and reduces inflammation by inhibiting NF‐κB.
Mengni Zhou, Renbin Dou, Rong Wu, Yunyu Xu, Ying Wang, Peng Wang, Jinfu Li, Pengcheng Lu, Yu Mao, Jieying Qian, Yunjiao Zhang, Jiqian Zhang, Shasha Zhu   +12 more
wiley   +1 more source

Future ocean climate homogenizes communities across habitats through diversity loss and rise of generalist species [PDF]

, 2019
Marco C. Brustolin, Ivan Nagelkerken, Camilo M. Ferreira, Silvan Urs Goldenberg, Hadayet Ullah, Gustavo Fonseca   +5 more
openalex   +1 more source

Effects of management practices on water yield in small headwater catchments at Cordillera de los Andes in southern Chile [PDF]

, 2009
In several parts of the world, drinking water is obtained from springs in natural and managed mountainous forests. Since forests regulate quality as well as quantity of water, the effects of forest-management activities on water yield are an important ...
Godoy, Roberto, Oyarzún, Carlos, Staelens, Jeroen, Verhoest, Niko   +3 more
core  

Overestimated climate warming and climate variability due to spatially homogeneous CO2 in climate modeling over the Northern Hemisphere since the mid-19th century

Scientific Reports, 2019
AbstractSince the mid-19th century, the global atmospheric CO2 concentration (ACC) has increased dramatically due to the burning of fossil fuels. Because of unequal population growth and economic development among regions, the ACC increases possess strong spatial variability. Particularly, the increase in ACC has been larger in the mid-latitudes of the
Xuezhen Zhang, Xiaxiang Li, Deliang Chen, Huijuan Cui, Quansheng Ge   +4 more
openaire   +2 more sources

Optimal Grazing Exclusion Duration to Enhance Soil Carbon Sequestration in Degraded Grasslands

Advanced Science, EarlyView.
Across China, grazing exclusion reaches the national mean soil organic carbon recovery benchmark sooner in high‐MAP regions (> 500 mm), but recovery is much slower where MAP < 300 mm. Scaling this strategy to 70% of China's degraded grasslands would sequester about 1.52 Pg of soil carbon over 10 years—roughly 17% of annual global fossil‐fuel emissions.
Bin Zhang, Chongzhi Sun, Dongmei Xue, Paul Christiaan Struik, Tongrui Zhang, Jiayue Liu, Tingting Xing, Ziyang Liu, Shiming Tang, Ke Jin   +9 more
wiley   +1 more source

A Novel Method for the Homogenization of Daily Temperature Series and Its Relevance for Climate Change Analysis [PDF]

, 2010
Andrea Toreti, Franz G. Kuglitsch, Elena Xoplaki, Jürg Luterbacher, Heinz Wanner   +4 more
openalex   +1 more source

Cars2‐Mediated Cysteine Catabolism Drives Brown Fat Development and Thermogenesis Through Persulfidating EBF2

Advanced Science, EarlyView.
We demonstrate that Cars2, a cysteine catabolic enzyme in mouse iBAT, is critical for cold tolerance and brown adipocyte differentiation. Through its CPERS activity, Cars2 produces CysSSH/H2S to induce EBF2 persulfidation, promoting its interaction with PPARγ and BRG1 to enhance thermogenic gene expression.
Xin Peng, Hongyong Song, Yin Long, Kaimin Wu, Yinkun Fu, Wenkai Zhou, Wenyan Li, Zhe Shi, Xu‐Yun Zhao   +8 more
wiley   +1 more source

Resource asynchrony and landscape homogenization as drivers of virulence evolution: The case of a directly transmitted disease in a social host

Ecology and Evolution
Throughout the last decades, the emergence of zoonotic diseases and the frequency of disease outbreaks have increased substantially, fuelled by habitat encroachment and vectors overlapping with more hosts due to global change.
Tobias Kürschner, Cédric Scherer, Viktoriia Radchuk, Niels Blaum, Stephanie Kramer‐Schadt   +4 more
doaj   +1 more source