Results 191 to 200 of about 311,541 (282)

Genomic introgressions from wild relatives in the wheat genome alter meiotic dynamics in inter-varietal hybrids. [PDF]

Plant J
Yan L, Chéron F, Nadaud I, Hao M, Liu D, Sourdille P.   +5 more
europepmc   +1 more source

Mass Spectrometry Structural Proteomics Enabled by Limited Proteolysis and Cross‐Linking

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The exploration of protein structure and function stands at the forefront of life science and represents an ever‐expanding focus in the development of proteomics. As mass spectrometry (MS) offers readout of protein conformational changes at both the protein and peptide levels, MS‐based structural proteomics is making significant strides in the
Haiyan Lu, Zexin Zhu, Lauren Fields, Hua Zhang, Lingjun Li   +4 more
wiley   +1 more source

An Exceptionally Complex Chromosome Rearrangement in the Great Tit <i>(Parus major)</i>: Genetic Composition, Meiotic Behavior and Population Frequency. [PDF]

Cells
Torgasheva A, Malinovskaya L, Nuriddinov M, Zadesenets KS, Gridina M, Nurislamov A, Korableva S, Pristyazhnyuk I, Proskuryakova A, Tishakova KV, Rubtsov NB, Fishman VS, Borodin P.   +12 more
europepmc   +1 more source

The courtship choreography of homologous chromosomes

Meiosis involves deep changes in the spatial organisation and interactions of chromosomes enabling the two primary functions of this process: increasing genetic diversity and reducing ploidy level. These two functions are ensured by crucial events such as homologous chromosomal pairing, synapsis, recombination and segregation.
Solé Canal, Mireia||, Pascual Leone, Álvaro||, Anton, Ester||, Blanco, Joan||, Sarrate Navas, Zaida||   +4 more
openaire   +1 more source

Missense Variants in the A Isoform of FGF13 as a Novel Cause of Paroxysmal Dyskinesia

Movement Disorders, EarlyView.
Abstract Background Pathogenic variants within the unique N‐terminal inactivation particle of FGF13 isoform A (FGF13A) have so far been associated only with an X‐linked dominant epileptic encephalopathy (DEE). Objective The aim was to expand the clinical and molecular spectrum of FGF13A‐related disorder.
Cyril Mignot, Matthildi Athina Papathanasiou Terzi, Claudia Ravelli, Elisabeth Bosch, Xueqin Lin, Adeline Trauffler, Roseline Caumes, Andrew E. Fry, Clementine Fort, Gaelle Gauthe, Regina Trollmann, Thomas Wirth, Mathieu Anheim, Aurélie Méneret, Emmanuel Roze, Jean‐Madeleine de Sainte Agathe, Hailan He, Eleni Panagiotakaki, Gaëtan Lesca, André Reis, Diane Doummar, Thomas Smol, Georgia Vasileiou   +22 more
wiley   +1 more source

Recursive Ectopic Gene Conversion Leads to Elevated DNA Mutation, Gene Loss, and Novel Gene Formation in Aspergillus. [PDF]

Microorganisms
Wang R, Liu W, Liu T, Wang T, Chen H, Qi H, Wang J, Lan M, Wang X.   +8 more
europepmc   +1 more source

Smart Integration of Structural Biology and Medicinal Chemistry to Unlock Target‐Driven Drug Discovery

Medicinal Research Reviews, EarlyView.
ABSTRACT To enhance drug discovery efforts, medicinal chemists should evaluate, filter, and utilize relevant structural information about target proteins. Acquiring and interpreting protein structures is crucial for elucidating ligand‐receptor interactions and addressing ADME‐related considerations, making it an essential aspect of medicinal chemistry.
Matteo Rossi Sebastiano, Giulia Apprato, Serena Francisco, Giuseppe Ermondi, Giulia Caron   +4 more
wiley   +1 more source

Modeling mammalian meiosis with pluripotent stem cells: progress and challenges. [PDF]

Clin Epigenetics
Yang F, Gu J, Chen H, Wang Y, Huang W, Chen X, Liu M, Yu X, Cp Cheung K.   +8 more
europepmc   +1 more source

High‐throughput transcriptome mining and in silico screening reveal saccharide feeding stimulants for Cydia pomonella larvae

New Plant Protection, EarlyView.
We identified and characterized the gustatory and ionotropic receptors of Cydia pomonella using transcriptomics and in silico approaches, linking candidate sugar receptors to larval feeding attraction. Functional assays and behavioral tests highlighted isoquercitrin as a key feeding stimulant, providing a foundation for olfactory‐ and taste‐based pest ...
Chenyun Ding, Zaiyuan Li, Qiang Wu, Bo Liu, Fanghao Wan, Cong Huang, Rui Tang   +6 more
wiley   +1 more source

Clinicopathological significance of loss of Y chromosome in male meningiomas

The Journal of Pathology, EarlyView.
Abstract Male meningiomas, comprising approximately 30% of all meningiomas, are more frequently high‐grade and associated with poorer clinical outcomes compared to their female counterparts. Although Y chromosome alterations have been studied in various male‐predominant tumors, a limited number of studies have evaluated their role in meningiomas.
Maki Sakaguchi, Masafumi Horie, Yukinobu Ito, Shingo Tanaka, Hiroko Ikeda, Mitsutoshi Nakada, Akihiko Yoshizawa, Daichi Maeda   +7 more
wiley   +1 more source