Results 111 to 120 of about 766,679 (374)

Global divergence of microbial genome sequences mediated by propagating fronts

, 2005
We model the competition between recombination and point mutation in microbial genomes, and present evidence for two distinct phases, one uniform, the other genetically diverse.
Berg, Doolittle, Feil, Feil, Feil, Gogarten, Guttman, Ivanova, Joyce, Kurtz, Lawrence, Lawrence, Li, Majewski, Majewski, Milkman, Ochman, Radding, Rasko, Sawyer, Smith, Treves, Tyson, Vulic   +23 more
core   +2 more sources

V_H replacement in rearranged immunoglobulin genes [PDF]

, 2005
Examples suggesting that all or part of the V_H segment of a rearranged V_HDJ_H may be replaced by all or part of another V_H have been appearing since the 1980s ...
Brokaw JL, Cascalho M, Choi Y, Chukwuocha RU, Covey LR, Cuomo CA, Deane M, Golub R, Han JO, Hesse JE, Kleinfield RW, Kobrin CB, Lewis SM, Ramsden DA, Rosenquist R, Shiokawa S, Sims GP, Steenbergen EJ, Steenbergen EJ, Taki S, Wasserman R, Wasserman R   +21 more
core   +2 more sources

Simultaneous Emission Spectral Narrowing and Spin‐Flip Acceleration in Multi‐Resonance Organoboron Emitters via Sequential Indolo‐Fusion π‐Extension

Advanced Optical Materials, EarlyView.
Sequential indolo‐fusion π‐extension as a rational design strategy to further narrow the emission bandwidth of multi‐resonance thermally activated delayed fluorescence is introduced. By fusing one or two additional indole moieties to the periphery of Cz‐B, gradual spectra narrowing and accelerated triplet–singlet exciton spin conversion are ...
Hyukgi Min, Takuma Yasuda
wiley   +1 more source

Homologous recombination-deficient tumors are hyper-dependent on POLQ-mediated repair

Nature, 2015
Large-scale genomic studies have shown that half of epithelial ovarian cancers (EOCs) have alterations in genes regulating homologous recombination (HR) repair.
Raphael Ceccaldi, Jessica C. Liu, R. Amunugama, Ildikó Hajdú, Benjamin Primack, Mark I. R. Petalcorin, Kevin W. O’Connor, P. Konstantinopoulos, S. Elledge, S. Boulton, T. Yusufzai, A. D’Andrea   +11 more
semanticscholar   +1 more source

A map of the diversity of RNA3 recombinants appearing in plants infected with cucumber mosaic virus and tomato aspermy virus [PDF]

, 2005
In order to better understand the role of recombination in creating the diversity of viral genomes that is acted on by selection, we have studied in detail the population of recombinant RNA3 molecules occurring in tobacco plants coinfected with wild-type
Belin, Christophe, de Wispelaere, Mélissanne, Gaubert, Stéphane, Tepfer, Mark, Trouilloud, Séverine   +4 more
core   +2 more sources

Self‐Adjusting Engineered Probiotic for Targeted Tumor Colonization and Local Therapeutics Delivery

Advanced Science, EarlyView.
Zou et al. developed an engineered strain of Escherichia coli Nissle 1917 with precise targeting abilities for colonization and on‐demand payload release. The engineered probiotic survives and embolizes tumors only in the presence of more than 5 mM L‐lactate. Furthermore, the introduction of an α‐hemolysin circuit enhances its anti‐tumor effect.
Zhen‐Ping Zou, Xin‐Ge Wang, Xuan‐Ren Shi, Shu‐Ting Sun, Jing Mi, Xiao‐Peng Zhang, Bin‐Cheng Yin, Ying Zhou, Bang‐Ce Ye   +8 more
wiley   +1 more source

HO Endonuclease-Initiated Recombination in Yeast Meiosis Fails To Promote Homologous Centromere Pairing and Is Not Constrained To Utilize the Dmc1 Recombinase

G3: Genes, Genomes, Genetics, 2018
Crossover recombination during meiosis is accompanied by a dramatic chromosome reorganization. In Saccharomyces cerevisiae, the onset of meiotic recombination by the Spo11 transesterase leads to stable pairwise associations between previously ...
Lina Yisehak, Amy J. MacQueen
doaj   +1 more source

Homologous Recombination Deficiency and Platinum-Based Therapy Outcomes in Advanced Breast Cancer

Clinical Cancer Research, 2017
Purpose: Recent studies have identified mutation signatures of homologous recombination deficiency (HRD) in over 20% of breast cancers, as well as pancreatic, ovarian, and gastric cancers.
E. Zhao, Yaoqing Shen, E. Pleasance, K. Kasaian, S. Leelakumari, Martin R. Jones, P. Bose, C. Ch'ng, C. Reisle, P. Eirew, R. Corbett, K. Mungall, N. Thiessen, Yussanne Ma, J. Schein, A. Mungall, Yongjun Zhao, Richard A. Moore, Wendie den Brok, Sheridan Wilson, D. Villa, T. Shenkier, C. Lohrisch, S. Chia, S. Yip, K. Gelmon, H. Lim, D. Renouf, Sophie Sun, K. Schrader, Sean S. Young, I. Bosdet, A. Karsan, J. Laskin, M. Marra, Steven J. M. Jones   +35 more
semanticscholar   +1 more source

Genetic Requirements for Intra-Chromosomal Deletions [PDF]

, 2020
Chromosomal deletions are one of the most dangerous types of DNA damage and often arise as a result of inappropriately repaired DNA double strand breaks (DSB).
McPherson, Matthew
core  

Molecular evolution of human adenoviruses [PDF]

, 2013
The recent emergence of highly virulent human adenoviruses (HAdVs) with new tissue tropisms underscores the need to determine their ontogeny. Here we report complete high quality genome sequences and analyses for all the previously unsequenced HAdV ...
Betensky, Rebecca Aubrey, Chodosh, James, Dehghan, Shoaleh, Dyer, David W., Jones, Morris S., Lee, Jeong Yoon, Liu, Elizabeth B., Rajaiya, Jaya, Robinson, Christopher, Seto, Donald, Singh, Gurdeep, Yousuf, Mohammad Abu   +11 more
core   +1 more source