Results 121 to 130 of about 783,358 (391)

HDAC4 regulates apoptosis in Acan‐CreERT2;HDAC4d/d mice with osteoarthritis by downregulating ATF4

open access: yesFEBS Open Bio, Volume 15, Issue 5, Page 726-737, May 2025.
Using the AcanCreERT2;HDAC4fl/fl genetic mouse model, we further investigated the role of histone deacetylase 4 (HDAC4) in chondrocyte apoptosis. We found that knocking down HDAC4 may be associated with chondrocyte apoptosis by upregulating the activating transcription factor 4 (ATF4)/CAAT/enhancer binding protein homologous (CHOP) signaling pathway ...
Jingrui Huang   +11 more
wiley   +1 more source

Envelope Ejection and the Transition to Homologous Expansion in Common-Envelope Events [PDF]

open access: yesarXiv, 2023
We conduct a long-timescale ($5000\,$d) 3-D simulation of a common-envelope event with a $2\,M_{\odot}$ red giant and a $1\,M_{\odot}$ main sequence companion, using the moving-mesh hydrodynamic solver MANGA. Starting with an orbital radius of $52\,R_{\odot}$, our binary shrinks to an orbital radius of $5\,R_{\odot}$ in $200\,$d.
arxiv  

Establishment and biological characterization of radioresistant colorectal cancer cell lines

open access: yesFEBS Open Bio, EarlyView.
Under ionizing radiation exposure, radiation‐sensitive cancer cells exhibit oxidative stress and DNA damage, while radiation‐resistant cancer cells exhibit strong antioxidant properties and DNA damage repair. Radiotherapy resistance is a major cause of recurrence and metastasis in colorectal cancer (CRC).
Tian‐Yin Qu   +10 more
wiley   +1 more source

A Mixture Model and a Hidden Markov Model to Simultaneously Detect Recombination Breakpoints and Reconstruct Phylogenies

open access: yesEvolutionary Bioinformatics, 2009
Homologous recombination is a pervasive biological process that affects sequences in all living organisms and viruses. In the presence of recombination, the evolutionary history of an alignment of homologous sequences cannot be properly depicted by a ...
Bastien Boussau   +2 more
doaj   +4 more sources

Is modularity the reason why recombination is so ubiquitous? [PDF]

open access: yesarXiv, 2012
Homologous recombination is an important operator in the evolution of biological organisms. However, there is still no clear, generally accepted understanding of why it exists and under what circumstances it is useful. In this paper we consider its utility in the context of an infinite population haploid model with selection and homologous ...
arxiv  

Arabidopsis RecQl4A suppresses homologous recombination and modulates DNA damage responses [PDF]

open access: yes, 2005
The DNA damage response and DNA recombination are two interrelated mechanisms involved in maintaining the integrity of the genome, but in plants they are poorly understood.
Bachrati   +64 more
core   +2 more sources

Possible role of human ribonuclease dicer in the regulation of R loops

open access: yesFEBS Open Bio, EarlyView.
R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik   +2 more
wiley   +1 more source

EXOSC10 is required for RPA assembly and controlled DNA end resection at DNA double-strand breaks [PDF]

open access: yes, 2019
The exosome is a ribonucleolytic complex that plays important roles in RNA metabolism. Here we show that the exosome is necessary for the repair of DNA double-strand breaks (DSBs) in human cells and that RNA clearance is an essential step in homologous ...
Bonath, Franziska   +7 more
core   +2 more sources

Interplay between Fanconi anemia and homologous recombination pathways in genome integrity

open access: yesEMBO Journal, 2016
The Fanconi anemia (FA) pathway plays a central role in the repair of DNA interstrand crosslinks (ICLs) and regulates cellular responses to replication stress. Homologous recombination (HR), the error‐free pathway for double‐strand break (DSB) repair, is
J. Michl, J. Zimmer, M. Tarsounas
semanticscholar   +1 more source

HO Endonuclease-Initiated Recombination in Yeast Meiosis Fails To Promote Homologous Centromere Pairing and Is Not Constrained To Utilize the Dmc1 Recombinase

open access: yesG3: Genes, Genomes, Genetics, 2018
Crossover recombination during meiosis is accompanied by a dramatic chromosome reorganization. In Saccharomyces cerevisiae, the onset of meiotic recombination by the Spo11 transesterase leads to stable pairwise associations between previously ...
Lina Yisehak, Amy J. MacQueen
doaj   +1 more source

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