Results 131 to 140 of about 345,396 (332)
Homologous recombination can restore normal immunoglobulin production in a mutant hybridoma cell line. [PDF]
, 1988 Mark D. Baker +3 more
openalex +1 more source
Advanced Science, EarlyView.In the present study, it is found that in osteosarcoma, lactate‐activated HCAR1 promotes β‐arrestin 2 translocation from cytoplasm to nucleus. In the nucleus, β‐arrestin 2 recruits PP2A to the activated STAT1/2 dimers, mediating STAT1/2 dephosphorylation and inhibiting the transcription of downstream anti‐oncogenes to promote OS progression.
Zhitao Han +26 more
wiley +1 more source
High-level transgene expression by homologous recombination-mediated gene transfer [PDF]
, 2017 Gene transfer and expression in eukaryotes is often limited by a number of stably maintained gene copies and by epigenetic silencing effects. Silencing may be limited by the use of epigenetic regulatory sequences such as matrix attachment regions (MAR ...
Beckmann, Jacques S. +9 more
core
Advanced Science, EarlyView.This study identified that STK33 may serve as a target of Bufalin, which induces the degradation of STK33 and inhibits the growth of TNBC. Furthermore, STK33 is highly expressed in TNBC and enhances TNBC cell proliferation by phosphorylating and stabilizing CCAR1.
Shilong Jiang +11 more
wiley +1 more source
Production of chimaeric mice containing embryonic stem (ES) cells carrying a homoeobox Hox 1.1 allele mutated by homologous recombination [PDF]
, 1989 Andreas Zimmer, Peter Gruss
openalex +1 more source
APOL2 Stabilizes Ku80 to Confer NHEJ‐Mediated Radioresistance in Gastric Cancer
Advanced Science, EarlyView.Radiotherapy resistance in gastric cancer (GC) is often mediated by enhanced DNA repair. APOL2 is found to promote NHEJ by stabilizing Ku80, conferring radioresistance. High APOL2 correlates with poor prognosis. Formononetin disrupts APOL2‐Ku80, restoring radiosensitivity, suggesting a novel therapeutic strategy.
Dan Zu +23 more
wiley +1 more source
Advanced Science, EarlyView.This study presents telomere‐to‐telomere genome assemblies for two populations of Larimichthys crocea. We identified centromere‐specific tandem repeats invaded by LTR/ERV1 retrotransposons, unique 5S rRNA enrichment patterns, and population‐specific structural variants. Comparative genomic analyses further reveal distinct adaptive mechanisms in the MYD
Yu Cui +9 more
wiley +1 more source
Homologous recombination of SV4O DNA in COS7 cells occurs with high frequency m a gene dose independent fashion [PDF]
, 1988 W Rommerskirch +3 more
openalex +1 more source
A two-phase approach for detecting recombination in nucleotide sequences
, 2007 Genetic recombination can produce heterogeneous phylogenetic histories within a set of homologous genes. Delineating recombination events is important in the study of molecular evolution, as inference of such events provides a clearer picture of the ...
Beiko, Robert G. +2 more
core