Results 131 to 140 of about 766,679 (374)
Eukaryotic DNA Polymerases in Homologous Recombination.
Annual Review of Genetics, 2016 Homologous recombination (HR) is a central process to ensure genomic stability in somatic cells and during meiosis. HR-associated DNA synthesis determines in large part the fidelity of the process.
M. McVey +4 more
semanticscholar +1 more source
Biosecurity Primitive: Polymerase X‐based Genetic Physical Unclonable Functions
Advanced Science, EarlyView.What if every cell line can carry an unforgeable genomic fingerprint—one that proves its origin, ensures its authenticity, and thwarts unauthorized duplication? Here, CRISPR‐induced DNA lesions paired with TdT‐mediated repair produce robust, unique, and unclonable genetic signatures—advancing the concept of molecular Physical Unclonable Functions (PUF)
Zikun Zhou +7 more
wiley +1 more source
The many facets of homologous recombination at telomeres
Microbial Cell, 2015 The ends of linear chromosomes are capped by nucleoprotein structures called telomeres. A dysfunctional telomere may resemble a DNA double-strand break (DSB), which is a severe form of DNA damage. The presence of one DSB is sufficient to
Clémence Claussin, Michael Chang
doaj +1 more source
Cell cycle-dependent control of homologous recombination.
Acta Biochimica et Biophysica Sinica, 2017 DNA double-strand breaks (DSBs) are among the most deleterious type of DNA lesions threatening genome integrity. Homologous recombination (HR) and non-homologous end joining (NHEJ) are two major pathways to repair DSBs.
Xin Zhao +6 more
semanticscholar +1 more source
Preface-Homologous Recombination
, 2021 DNA double-strand breaks (DSBs) are the most harmful lesions to DNA in the cell. To cope with these insults, all organisms have devised two main types of evolutionary conserved mechanisms for their repair, homologous recombination (HR), and non-homologous end joining (NHEJ).
Aguilera, Andrés, Carreira, Aura
openaire +1 more source
Advanced Science, EarlyView.This study highlights the role of connexin43 (Cx43) in mediating glia activation and neuroinflammation in glaucoma. Using Cx43 knockout mice, it is shown that macroglial cells‐derived Cx43 modulates microglial activation, proliferation, migration, and polarization.
Guoli Zhao +17 more
wiley +1 more source
Spatiotemporal dynamics of homologous recombination repair at single collapsed replication forks
Nature Communications, 2018 How factors involved in homologous recombination interact and function is a matter of interest. Here the authors use super-resolution imaging to describe the spatiotemporal dynamics of proteins associated with homologous recombination DNA repair in ...
Donna R. Whelan +7 more
doaj +1 more source
Advanced Science, EarlyView.This study integrates dual‐reporter genetics, imaging flow cytometry, and single‐cell sequencing to characterize rare bihormonal cells in mouse and human pancreatic islets. Gcg⁺Ins⁺ cells resemble α‐cells rather than transitional states. Cross‐species gene network analysis refines islet cell taxonomy and reveals human‐specific δ‐cell subtypes ...
Xin‐Xin Yu +10 more
wiley +1 more source
Advanced Science, EarlyView.CRISPR/Cas9, while transformative, faces challenges in specificity, precision, delivery, accessibility, flexibility, and safety. This review addresses these limitations by highlighting strategies to reduce off‐target effects, exploring HDR‐based and alternative editing approaches, and evaluating advanced delivery mechanisms.
Muna Alariqi +8 more
wiley +1 more source
eLife, 2014 The activation induced cytidine deaminase (AID) protein is known to initiate somatic hypermutation, gene conversion or switch recombination by cytidine deamination within the immunoglobulin loci.
Jean-Marie Buerstedde +2 more
doaj +1 more source