Shu complex SWS1-SWSAP1 promotes early steps in mouse meiotic recombination
Nature Communications, 2018 Homologous recombination ensures genome integrity during meiotic recombination. Here the authors reveal that factors SWS1 and SWSAP1 are critical for meiotic homologues recombination, particularly in promoting assembly of RAD51 and DMC1 on early ...
Carla M. Abreu +5 more
doaj +1 more source
Germ-line transmission of a planned alteration made in a hypoxanthine phosphoribosyltransferase gene by homologous recombination in embryonic stem cells. [PDF]
, 1989 Beverly H. Koller +8 more
openalex +1 more source
Assembly and Functionality of 2D Protein Arrays
Advanced Science, EarlyView.2D protein arrays‐based outstanding properties, including their remarkable structural stability, exceptional physiochemical properties, and tunable electronic and mechanical attributes, have become a key functional platform for developing advanced functional materials.
Mingming Du +6 more
wiley +1 more source
Hepatology, EarlyView., 2022 Physiological activation of myeloid p38 controls macrophage IL‐12 production and crosstalk to the liver by modulating hepatic FGF21, and subsequently, brown adipose tissue thermogenesis during obesity Abstract Obesity features excessive fat accumulation in several body tissues and induces a state of chronic low‐grade inflammation that contributes to ...
María Crespo +14 more
wiley +1 more source
Category theory for genetics II: genotype, phenotype and haplotype [PDF]
arXiv, 2018 The overarching goal of this paper is to solve the word problem for a class of idempotent commutative monoids whose elements model population haplotypes. More specifically, we design an algebraic framework in which it is possible to unravel population stratification relationships and infer linkage disequilibrium in terms of algebraic equations of ...
arxiv
Efficient repair of HO-induced chromosomal breaks in Saccharomyces cerevisiae by recombination between flanking homologous sequences. [PDF]
, 1988 Norah Rudin, James E. Haber
openalex +1 more source
Engineered Probiotics Mitigate Gut Barrier Dysfunction Induced by Nanoplastics
Advanced Science, EarlyView.Intestinal barrier stability is vital for gut health. Plastic polyethylene terephthalate (PET) disrupts this barrier, causing inflammation and infections. This study encodes transforming growth factor‐β into EcN and modifies its surface with pH‐responsive polymer (EcNT@L), creating an oral drug delivery system to repair nano PET‐induced intestinal ...
Wenxin Chen +9 more
wiley +1 more source
Human Mutation, Volume 43, Issue 12, Page 1921-1944, December 2022., 2022 Abstract Skipping of BRCA2 exon 3 (∆E3) is a naturally occurring splicing event, complicating clinical classification of variants that may alter ∆E3 expression. This study used multiple evidence types to assess pathogenicity of 85 variants in/near BRCA2 exon 3.
Mads Thomassen +49 more
wiley +1 more source
Homologous alpha satellite sequences on human acrocentric chromosomes with selectivity for chromosomes 13, 14 and 21: implications for recombination between nonhomologues and Robertsonian translocations [PDF]
, 1988 K. H. Andy Choo +4 more
openalex +1 more source
Somatic mutations reveal complex metastatic seeding from multifocal primary prostate cancer
International Journal of Cancer, Volume 152, Issue 5, Page 945-951, 1 March 2023., 2023 What's new? Intrapatient tumor heterogeneity and clonal evolution of primary tumor foci into metastatic disease remain significant challenges for prostate cancer treatment. Here, investigating metastatic lesion origins, the authors compared somatic mutations in spatially distinct primary foci to mutations in recurring disease in seven prostate cancer ...
Kristina T. Carm +9 more
wiley +1 more source