Results 141 to 150 of about 218,555 (316)
Progressive Mauve: Multiple alignment of genomes with gene flux and rearrangement [PDF]
arXiv, 2009 Multiple genome alignment remains a challenging problem. Effects of recombination including rearrangement, segmental duplication, gain, and loss can create a mosaic pattern of homology even among closely related organisms. We describe a method to align two or more genomes that have undergone large-scale recombination, particularly genomes that have ...
arxiv
Effect of double-strand breaks on homologous recombination in mammalian cells and extracts. [PDF]
, 1985 K Y Song +4 more
openalex +1 more source
International Journal of Cancer, Volume 152, Issue 5, Page 921-931, 1 March 2023., 2023 What's new? Despite the recent approval of novel therapeutics for germline BRCA1/2‐mutated metastatic breast cancer, data regarding outcomes and optimal treatment strategies are lacking. This study assessed the impact of germline BRCA mutations on metastatic breast cancer survival using data from a cohort of patients treated in an era predating PARP ...
Audrey Mailliez +21 more
wiley +1 more source
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT SATB2‐associated syndrome (SAS) is characterized by intellectual disability, neurodevelopmental disorders, cleft palate, and dental abnormalities. SAS is caused by variants in the special AT‐rich sequence‐binding protein 2 (SATB2), which encodes a transcription factor containing two CUT domains and a homeobox (HOX) domain.
Nao Ukita +5 more
wiley +1 more source
Animal Models and Experimental Medicine, EarlyView.ApoA4‐Cre rats and Cyp2c11‐Cre rats were produced using CRISPR/Cas9 tool. The Cre rats were crossed with Rosa26‐imCherry rats to obtain the Apoa4‐Cre/Rosa26‐imCherry and Cyp2c11‐Cre/Rosa26‐imCherry rats, which showed the specific expression of Cre recombinases in the liver.
Wei Dong +6 more
wiley +1 more source
Animal Models and Experimental Medicine, EarlyView.It is increasingly recognized that young, chow‐fed inbred mice poorly model the complexity of human carcinogenesis in multiple respects. In humans, age and adiposity are the major risk factors for the majority of malignancies. Although the development of genetically engineered mouse models (GEMM) of cancer has recapitulated many aspects of human cancer,
Iqbal M. Lone +4 more
wiley +1 more source
Two cases of CRPC with BRCA mutation treated by olaparib after favorable response to cisplatin
IJU Case Reports, Volume 6, Issue 1, Page 37-40, January 2023., 2023 Introduction Several prostate cancers carry homologous recombination repair mutations that respond to olaparib. Because of the mechanism, the efficacy of platinum‐based therapy can be used to predict the efficacy of poly(adenosine diphosphate‐ribose) polymerase inhibitors such as olaparib.
Yoshiyuki Miyazawa +9 more
wiley +1 more source
Homologous Recombination and the Repair of Double-Strand Breaks During Cotransformation of Dictyostelium discoideum [PDF]
, 1988 Kenneth Katz, David I. Ratner
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Production of chimaeric mice containing embryonic stem (ES) cells carrying a homoeobox Hox 1.1 allele mutated by homologous recombination [PDF]
, 1989 Andreas Zimmer, Peter Gruss
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