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Role of SIRT1 in homologous recombination
DNA Repair, 2010The class III histone deacetylase (HDAC) SIRT1 plays a role in the metabolism, aging, and carcinogenesis of organisms and regulates senescence and apoptosis in cells. Recent reports revealed that SIRT1 also deacetylates several DNA double-strand break (DSB) repair proteins. However, its exact functions in DNA repair remained elusive. Using nuclear foci
Miriam, Uhl +5 more
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Role of homologous recombination in carcinogenesis
Experimental and Molecular Pathology, 2003Cancer develops when cells no longer follow their normal pattern of controlled growth. In the absence or disregard of such regulation, resulting from changes in their genetic makeup, these errant cells acquire a growth advantage, expanding into precancerous clones.
Alexander J R, Bishop +1 more
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Quality control of homologous recombination
Cellular and Molecular Life Sciences, 2014Exogenous and endogenous genotoxic agents, such as ionizing radiation and numerous chemical agents, cause DNA double-strand breaks (DSBs), which are highly toxic and lead to genomic instability or tumorigenesis if not repaired accurately and efficiently.
Ting, Liu, Jun, Huang
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Gene Replacement by Homologous Recombination
2019While homologous recombination-based gene replacement is about to be supplanted by more modern approaches, it is still retaining usefulness for genes that prove to be poor targets for CRISPR/cas-based approaches. Homologous recombination has proven to be relatively robust to minor sequence mismatches between GOI-flanking sequences and the gene ...
Henner, Zirpel, Joachim, Clos
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Involvement of Homologous Recombination in Carcinogenesis
2007DNA alterations of every type are associated with the incidence of carcinogenesis, often on the genomic scale. Although homologous recombination (HR) is an important pathway of DNA repair, evidence is accumulating that deleterious genomic rearrangements can result from HR. It therefore follows that HR events may play a causative role in carcinogenesis.
Ramune, Reliene +2 more
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Biochemistry of eukaryotic homologous recombination
2006The biochemistry of eukaryotic homologous recombination caught fire with the discovery that Rad51 is the eukaryotic homolog of the bacterial RecA and T4 UvsX proteins; and this field is still hot. The core reaction of homologous recombination, homology search and DNA strand invasion, along with the proteins catalyzing it, are conserved throughout ...
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Homologous Recombination in Plants: An Antireview
2010Homologous recombination (HR) is a central cellular process involved in many aspects of genome maintenance such as DNA repair, replication, telomere maintenance, and meiotic chromosomal segregation. HR is highly conserved among eukaryotes, contributing to genome stability as well as to the generation of genetic diversity.
Michal, Lieberman-Lazarovich +1 more
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Mechanisms for homologous recombination
Nature, 1985A, Nicolas, J L, Rossignol
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