Results 301 to 310 of about 651,783 (359)

Gene editing of NCF1 loci is associated with homologous recombination and chromosomal rearrangements. [PDF]

Commun Biol
Raimondi F, Siow KM, Wrona D, Fuster-García C, Pastukhov O, Schmitz M, Bargsten K, Kissling L, Swarts DC, Andrieux G, Cathomen T, Modlich U, Jinek M, Siler U, Reichenbach J.   +14 more
europepmc   +1 more source

Photoaffinity labeling coupled to MS to identify peptide biological partners: Secondary reactions, for better or for worse?

Mass Spectrometry Reviews, EarlyView.
Abstract Affinity photolabeling is a smart method to study noncovalent and transient interactions and provide a submolecular picture of the contacts between interacting partners. In this review, we will focus on the identification of peptide partners using photoaffinity labeling coupled to mass spectrometry in different contexts such as in vitro with a
Astrid Walrant, Emmanuelle Sachon
wiley   +1 more source

Evolution of homologous recombination rates across bacteria. [PDF]

Proc Natl Acad Sci U S A
Torrance EL, Burton C, Diop A, Bobay LM.
europepmc   +1 more source

Leveraging collateral sensitivity to counteract the evolution of bacteriophage resistance in bacteria

mLife, EarlyView.
Abstract The escalating antibiotic resistance crisis poses a major global health threat. Bacteriophage therapy offers a promising alternative for combating multidrug‐resistant infections. However, bacterial resistance to phages remains a significant hurdle. Innovative strategies are needed to overcome this challenge. In this study, we developed a phage
Yongqi Mu, Yuqin Song, Xueru Tian, Zixuan Ding, Shigang Yao, Yi Li, Chao Wang, Dawei Wei, Waldemar Vollmer, Gang Zhang, Jie Feng   +10 more
wiley   +1 more source

Defective homologous recombination and genomic instability predict increased responsiveness to carbon ion radiotherapy in pancreatic cancer. [PDF]

NPJ Precis Oncol
Sishc BJ, Saha J, Alves EM, Ding L, Lu H, Wang SY, Swancutt KL, Nicholson JH, Facoetti A, Pompos A, Ciocca M, Aguilera TA, Story MD, Davis AJ.   +13 more
europepmc   +1 more source

The GntR/VanR transcription regulator AlkR represses AlkB2 monooxygenase expression and regulates n‐alkane degradation in Pseudomonas aeruginosa SJTD‐1

mLife, EarlyView.
Abstract Transmembrane alkane monooxygenase (AlkB)‐type monooxygenases, especially AlkB2 monooxygenases, are crucial for aerobic degradation of the medium‐to‐long‐chain n‐alkanes in hydrocarbon‐utilizing microorganisms. In this study, we identified a GntR/VanR transcription regulator AlkR of Pseudomonas aeruginosa SJTD‐1 involved in the negative ...
Wanli Peng, Xiuli Wang, Qinchen Liu, Zhihong Xiao, Fulin Li, Nannan Ji, Zhuo Chen, Jiaying He, Junhao Wang, Zixin Deng, Shuangjun Lin, Rubing Liang   +11 more
wiley   +1 more source

Overall survival with maintenance olaparib in platinum-sensitive relapsed ovarian cancer by somatic or germline BRCA and homologous recombination repair mutation status. [PDF]

Br J Cancer
Pignata S, Oza A, Hall G, Pardo B, Madry R, Cibula D, Klat J, Montes A, Glasspool R, Colombo N, Pete I, Herrero Ibáñez A, Romeo M, Ilieva R, Timcheva C, Di Maio M, Bashir Z, Taylor R, Barnicle A, Clamp A.   +19 more
europepmc   +1 more source

A CRISPR‐nonhomologous end‐joining‐based strategy for rapid and efficient gene disruption in Mycobacterium abscessus

mLife, EarlyView.
Abstract Mycobacterium abscessus, a fast‐growing, non‐tuberculous mycobacterium resistant to most antimicrobial drugs, causes a wide range of serious infections in humans, posing a significant public health challenge. The development of effective genetic manipulation tools for M.
Sanshan Zeng, Yanan Ju, Md Shah Alam, Ziwen Lu, H. M. Adnan Hameed, Lijie Li, Xirong Tian, Cuiting Fang, Xiange Fang, Jie Ding, Xinyue Wang, Jinxing Hu, Shuai Wang, Tianyu Zhang   +13 more
wiley   +1 more source

Low dose DNA methyltransferase inhibitors potentiate PARP inhibitors in homologous recombination repair deficient tumors. [PDF]

Breast Cancer Res
Pacaud R, Thomas S, Chaudhuri S, Lazar A, Timmerman LA, Munster PN.   +5 more
europepmc   +1 more source

Effects of Natural Polysaccharides on the Gut Microbiota Related to Human Metabolic Health

Molecular Nutrition &Food Research, EarlyView.
The graphical abstract illustrates the role of polysaccharides extracted from various natural raw materials (such as mushrooms, marine organisms, fruits, and vegetables) in modulating the gut microbiota. The process begins with the extraction and purification of polysaccharides, followed by assessing their structure‐activity relationship. Upon entering
Yigang Huang, Hongfei Guo, Yuchen Liu, Wengang Jin, Chella Perumal Palanisamy, Jinjin Pei, Fatih Oz, A. M. Abd El‐Aty   +7 more
wiley   +1 more source