Results 301 to 310 of about 766,679 (374)

Efficient Synthesis of Steroidal Intermediates with a C17 Side Chain from Phytosterols by Genetically Modified Mycolicibacterium neoaurum NRRL B‐3805 Strain

ChemistryOpen, EarlyView.
Two genetically modified strains are designed and constructed to produce 22‐hydroxy‐23,24‐bisnorchol‐4‐ene‐3‐one (4‐HBC) and 3‐oxo‐4,17‐pregnadiene‐20‐carboxylic acid methyl ester (PDCE) by disrupting and overexpressing the aldolase gene (thl) in the genetically modified strains of Mycolicibacterium neoaurum NRRL B‐3805, respectively, which are useful ...
Xuemei Li, Liangyan Zhu, Qiong Wu, Rui Zhang, Yiyin Liu, Na Liu, Jinhui Feng, Qiaqing Wu, Dunming Zhu   +8 more
wiley   +1 more source

Homologous recombination deficiency test validation in patients with high-grade advanced ovarian cancer. [PDF]

Front Mol Biosci
Nogueira Rodrigues A, Souto AKBA, de Andrade DAP, Gomes LM, Koide SS, E Silva RG, de Souza BB, Massaro JD, de Melo AC, Borges AM, Giro C, de Andrade CAV, da Costa CM, Gimenes DL, de Mello ECB, de Oliveira FC, Lima FMT, Lopes GL, Bretas GO, Jacob GG, Silva HLDC, Notaro JF, Alves LL, Moitinho MV, da Silva MC, Abramoff R, Rauber TADC, Dienstmann R, Koyama FC.   +28 more
europepmc   +1 more source

Analysis of IDH1 and IDH2 mutations as causes of the hypermethylator phenotype in colorectal cancer

The Journal of Pathology, EarlyView.
Abstract The CpG island methylator phenotype (CIMP) occurs in many colorectal cancers (CRCs). CIMP is closely associated with global hypermethylation and tends to occur in proximal tumours with microsatellite instability (MSI), but its origins have been obscure.
Joseph C Ward, Melissa Morgan, James Wood, Connor Woolley, Albert Antao Nobre de Menezes, Alina Finch, Kitty Sherwood, Qiwen Huang, Chloe S Henry, Juan Fernández‐Tajes, Ignacio Soriano, Steve Thorn, Isabelle Legge, James McCullagh, David Kerr, Rachel Kerr, Rahul K Hejmadi, Mark J Arends, The S:CORT Consortium, Richard Adams, Simon Bach, Andrew Beggs, Louise Brown, Francesca Buffa, Jean‐Baptiste Cazier, Enric Domingo, Andrew Blake, Che‐Hsi Wu, Ekaterina Chatzpili, Susan Richman, Philip Dunne, Paul Harkin, Geoff Higgins, Jim Hill, Chris Holmes, Denis Horgan, Rick Kaplan, Richard Kennedy, Mark Lawler, Simon Leedham, Ultan McDermott, Gillies McKenna, Gary Middleton, Dion Morton, Graeme Murray, Philip Quirke, Manuel Salto‐Tellez, Les Samuel, Anna Schuh, David Sebag‐Montefiore, Matt Seymour, Ricky Sharma, Richard Sullivan, Ian Tomlinson, Nicholas West, Richard Wilson, Enric Domingo, Timothy Maughan, Chiara Bardella, Ian Tomlinson   +59 more
wiley   +1 more source

PLK1 overexpression suppresses homologous recombination and confers cellular sensitivity to PARP inhibition. [PDF]

Sci Rep
Pae S, Sedukhina AS, Sugiyama R, Atanacio SJ, Ohara T, Ishii M, Minagawa K, Akichjev R, Go F, Chandankeri Z, Janjetic ZMM, Sato E, Yamaura A, Meguro R, Palanisamy K, Maeda I, Takeuchi O, Suzuki N, Yudo K, Bernal JA, Sato K.   +20 more
europepmc   +1 more source

Homologous recombination following transformation in Neurospora crassa wild type and mutagen sensitive strains

, 1995
Alice Schroeder, Martin L. Pall, James Lotzgesell, Jacie Siino   +3 more
openalex   +2 more sources

Key Regulators of Parasite Biology Viewed Through a Post‐Translational Modification Repertoire

PROTEOMICS, EarlyView.
ABSTRACT Parasites are the leading causes of morbidity and mortality in both humans and animals, imposing substantial socioeconomic burdens worldwide. Controlling parasitic diseases has become one of the key issues in achieving “One Health”. Most parasites have sophisticated life cycles exhibiting progressive developmental stages, morphologies, and ...
Naiwen Zhang, Ning Jiang, Qijun Chen
wiley   +1 more source

Pan-Cancer Analysis of Homologous Recombination Deficiency in Cell Lines. [PDF]

Cancer Res Commun
Dodson AE, Shenker S, Sullivan P, Nayak SU, Middleton C, McGuire M, Chipumuro E, Mishina Y, Tobin ER, Cadzow L, Wylie AA, Sangurdekar D.   +11 more
europepmc   +1 more source

Efficient homologous recombination in fast-growing and slow-growing mycobacteria

, 1996
Alain R. Baulard, Laurent Kremer, Camille Locht   +2 more
openalex   +1 more source

Chloroplast genome diversity and phylogenetic insights of Saccharum spontaneum across Southeast Asia

PLANTS, PEOPLE, PLANET, EarlyView.
Climate change and threats to global food security have increased the urgency of conserving genetic resources in key crops like sugarcane. In this study, we analyzed the chloroplast genomes of wild sugarcane to assess their genetic diversity and population structure. We found a high level of diversity, regardless of geographic location, and patterns of
Sicheng Li, Zhen Wang, Chaohua Xu, Lijun Zhang, Baoqing Zhang, Yuxin Huang, Xin Lu, Weixing Duan, Xiping Yang   +8 more
wiley   +1 more source

Homologous recombination deficiency (HRD) testing landscape: clinical applications and technical validation for routine diagnostics. [PDF]

Biomark Res
Witz A, Dardare J, Betz M, Michel C, Husson M, Gilson P, Merlin JL, Harlé A.   +7 more
europepmc   +1 more source