Results 311 to 320 of about 766,679 (374)

Germline Testing for Prostate Cancer Patients: Evidence‐Based Evaluation of Genes Recommended by NCCN Guidelines

The Prostate, EarlyView.
ABSTRACT Background Approximately 50% of prostate cancer (PCa) patients meet the National Comprehensive Cancer Network (NCCN) guidelines for germline testing at diagnosis. However, the selection of genes for testing, their supporting evidence, and clinical interpretation remain poorly understood.
Jianfeng Xu, Jim Lu, Marta Gielzak, S. Lilly Zheng, Lucy Lu, Jun Wei, Brandon Cornell, Zhuqing Shi, Qiang Wang, Huy Tran, Valentina Engelmann, Annabelle Ashworth, Kirk Lin, Ashley E. Ross, Patrick C. Walsh, Catherine Marshall, Jun Luo, William B. Isaacs, Brian T. Helfand, Christian P. Pavlovich   +19 more
wiley   +1 more source

Whole exome sequencing-based homologous recombination deficiency test for epithelial ovarian cancer. [PDF]

J Ovarian Res
Chiang YC, Huang HN, Kuo KT, Hwu WL, Lin PH.   +4 more
europepmc   +1 more source

Comprehensive Genomic Profiling Testing for Castration‐Resistant Prostate Cancer in Advanced Elderly Patients: A Single‐Center Retrospective Cohort Study

The Prostate, EarlyView.
ABSTRACT Background Prostate cancer (PCa) is the second most common solid tumor in men, and its incidence is strongly dependent on age. With the aging global population, this poses a significant medical and sociodemographic issue. As treatment options for castration‐resistant prostate cancer (CRPC) expand, the proportion of elderly patients with CRPC ...
Takafumi Fukushima, Keisuke Goto, Yoshinori Nakano, Shinsaku Tasaka, Kyohsuke Iwane, Ryo Tasaka, Kohei Kobatake, Akihiro Goriki, Asuka Toshida, Akiko Abe, Misako Ishihara, Hikaru Nakahara, Masanori Motonaga, Kentaro Tokumo, Yasutoshi Fujii, Hayes Clair Nelson, Hiroaki Niitsu, Shinya Ohara, Yuji Urabe, Wataru Okamoto, Eiso Hiyama, Koji Arihiro, Takao Hinoi, Nobuyuki Hinata   +23 more
wiley   +1 more source

Causative Genes of Homologous Recombination Deficiency (HRD)-Related Breast Cancer and Specific Strategies at Present. [PDF]

Curr Oncol
Nakamura S, Kojima Y, Takeuchi S.
europepmc   +1 more source

Crystal Structure and Functional Characterization of YjgK From Salmonella Typhimurium

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The YhcH/YjgK/YiaL (DUF386) family, widely conserved across bacterial species, is involved in essential cellular processes yet remains poorly characterized. YjgK from Salmonella enterica serovar Typhimurium has drawn attention because of its potential role in biofilm formation associated with metal homeostasis, which may be critical for ...
Su‐Yeon Choi, Eunsuk Kim, Hyunjin Yoon, Ha‐Neul Kim, Ji‐Hun Kim, Seung‐Hyeon Seok, Min‐Duk Seo   +6 more
wiley   +1 more source

Structural Analysis of the SARS‐CoV‐2 Spike N‐Terminal Domain Across Wild‐Type and Recent Variants: A Comparative Study

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Since its first appearance in China, the molecular evolution of SARS‐CoV‐2 has progressed through altering the properties of the Spike protein, changing the virus ability to transmit and to evade host immune surveillance. Despite receiving less attention than the Receptor Binding Domain (RBD), the Spike N‐Terminal Domain (NTD) is crucial to ...
Miriana Quaranta, Allegra Via, Stefano Pascarella   +2 more
wiley   +1 more source

Characterization of TNG348: A Selective, Allosteric USP1 Inhibitor That Synergizes with PARP Inhibitors in Tumors with Homologous Recombination Deficiency. [PDF]

Mol Cancer Ther
Simoneau A, Pratt CB, Wu HJ, Rajeswaran SS, Comer CG, Sudsakorn S, Zhang W, Liu S, Meier SR, Choi AH, Khendu T, Stowe H, Shen B, Whittington DA, Chen Y, Yu Y, Mallender WD, Feng T, Andersen JN, Maxwell JP, Throner S.   +20 more
europepmc   +1 more source

Single and dual RPA‐CRISPR/Cas assays for point‐of‐need detection of Stewart's wilt pathogen (Pantoea stewartii subsp. stewartii) of corn and Maize dwarf mosaic virus

Pest Management Science, Volume 81, Issue 4, Page 1988-1999, April 2025.
Schematic diagram of the single and dual RPA‐CRISPR/Cas12a/13a diagnostic assays for the detection of Pantoea stewartii subsp. stewartii and Maize dwarf mosaic virus. The validated assays provide a useful and sensitive molecular tool for detecting two quarantine pathogens of maize within a minimal resource framework suitable for fast‐tracking the ...
Qian Tian, Hua Zhou, Zhenxing Zhao, Yongjiang Zhang, Wenjun Zhao, Lulu Cai, Tao Guo   +6 more
wiley   +1 more source

Homologous recombination-DNA damage response defects increase TMB and neoantigen load, but not effector T cell density and clonal diversity in pancreatic cancer. [PDF]

Exp Hematol Oncol
Lei M, Gai J, McPhaul TJ, Luo H, Lin P, Liu D, Pishvaian M, Roberts NJ, Wu K, He J, Zheng L.   +10 more
europepmc   +1 more source

Threshold Concepts and Concept Networks in Evolution Education: An Experimental Intervention Study

Science Education, EarlyView.
ABSTRACT This study analyzes the effect of different instructions on threshold concepts within material covering natural selection on students' use of concepts about evolution. Moreover, it examines students' use of concepts as interconnected networks when reasoning about natural selection and analyzes how these concepts relate to each other regarding ...
Helena Aptyka, Daniela Fiedler, Jörg Großschedl   +2 more
wiley   +1 more source