Results 311 to 320 of about 773,827 (377)

DirectHRD enables sensitive scar-based classification of homologous recombination deficiency. [PDF]

Nucleic Acids Res
Liu R, Roberts E, Parsons HA, Stover EH, Choudhury AD, Rhoades J, Blewett T, Yang DD, Liu JF, Mayer EL, Adalsteinsson VA.   +10 more
europepmc   +1 more source

Key Regulators of Parasite Biology Viewed Through a Post‐Translational Modification Repertoire

PROTEOMICS, EarlyView.
ABSTRACT Parasites are the leading causes of morbidity and mortality in both humans and animals, imposing substantial socioeconomic burdens worldwide. Controlling parasitic diseases has become one of the key issues in achieving “One Health”. Most parasites have sophisticated life cycles exhibiting progressive developmental stages, morphologies, and ...
Naiwen Zhang, Ning Jiang, Qijun Chen
wiley   +1 more source

The inflammasome sensor NLRP3 interacts with REV7 to maintain genome integrity through homologous recombination. [PDF]

Nucleic Acids Res
Burlet D, Khan MM, Hacot S, Buthmann H, Bardoulet L, Huber AL, Gorry J, Föhr B, Lopez BS, Couté Y, Faesen AC, Geyer M, Tissier A, Petrilli V.   +13 more
europepmc   +1 more source

Chloroplast genome diversity and phylogenetic insights of Saccharum spontaneum across Southeast Asia

PLANTS, PEOPLE, PLANET, EarlyView.
Climate change and threats to global food security have increased the urgency of conserving genetic resources in key crops like sugarcane. In this study, we analyzed the chloroplast genomes of wild sugarcane to assess their genetic diversity and population structure. We found a high level of diversity, regardless of geographic location, and patterns of
Sicheng Li, Zhen Wang, Chaohua Xu, Lijun Zhang, Baoqing Zhang, Yuxin Huang, Xin Lu, Weixing Duan, Xiping Yang   +8 more
wiley   +1 more source

Breast cancer homologous recombination deficiency prediction from pathological images with a sufficient and representative Transformer. [PDF]

NPJ Precis Oncol
Luan H, Hu T, Hu J, Liu W, Yang K, Pei Y, Li R, He J, Gao Y, Sun D, Duan X, Yan R, Zhou SK, Niu B.   +13 more
europepmc   +1 more source

Crystal Structure and Functional Characterization of YjgK From Salmonella Typhimurium

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The YhcH/YjgK/YiaL (DUF386) family, widely conserved across bacterial species, is involved in essential cellular processes yet remains poorly characterized. YjgK from Salmonella enterica serovar Typhimurium has drawn attention because of its potential role in biofilm formation associated with metal homeostasis, which may be critical for ...
Su‐Yeon Choi, Eunsuk Kim, Hyunjin Yoon, Ha‐Neul Kim, Ji‐Hun Kim, Seung‐Hyeon Seok, Min‐Duk Seo   +6 more
wiley   +1 more source

The impact of homologous recombination deficiency on the prognosis of epithelial ovarian cancer. [PDF]

Clin Transl Med
Su H, Wang Y, Chao X, Wu H, You Y, Zhao S, Wang F, Sun B, Zhang Z, Wu M, Zhao Z, Li L.   +11 more
europepmc   +1 more source

Structural Analysis of the SARS‐CoV‐2 Spike N‐Terminal Domain Across Wild‐Type and Recent Variants: A Comparative Study

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Since its first appearance in China, the molecular evolution of SARS‐CoV‐2 has progressed through altering the properties of the Spike protein, changing the virus ability to transmit and to evade host immune surveillance. Despite receiving less attention than the Receptor Binding Domain (RBD), the Spike N‐Terminal Domain (NTD) is crucial to ...
Miriana Quaranta, Allegra Via, Stefano Pascarella   +2 more
wiley   +1 more source

Prognostic signature detects homologous recombination deficient in glioblastoma. [PDF]

Transl Cancer Res
Luo D, Luo A, Hu S, Zhao H, Yao X, Li D, Peng B.   +6 more
europepmc   +1 more source

Functional Relevance of CASP16 Nucleic Acid Predictions as Evaluated by Structure Providers

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Accurate biomolecular structure prediction enables the prediction of mutational effects, the speculation of function based on predicted structural homology, the analysis of ligand binding modes, experimental model building, and many other applications.
Rachael C. Kretsch, Reinhard Albrecht, Ebbe S. Andersen, Hsuan‐Ai Chen, Wah Chiu, Rhiju Das, Jeanine G. Gezelle, Marcus D. Hartmann, Claudia Höbartner, Yimin Hu, Shekhar Jadhav, Philip E. Johnson, Christopher P. Jones, Deepak Koirala, Emil L. Kristoffersen, Eric Largy, Anna Lewicka, Cameron D. Mackereth, Marco Marcia, Michela Nigro, Manju Ojha, Joseph A. Piccirilli, Phoebe A. Rice, Heewhan Shin, Anna‐Lena Steckelberg, Zhaoming Su, Yoshita Srivastava, Liu Wang, Yuan Wu, Jiahao Xie, Nikolaj H. Zwergius, John Moult, Andriy Kryshtafovych   +32 more
wiley   +1 more source