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Innovation by homologous recombination
Current Opinion in Chemical Biology, 2013Swapping fragments among protein homologs can produce chimeric proteins with a wide range of properties, including properties not exhibited by the parents. Computational methods that use information from structures and sequence alignments have been used to design highly functional chimeras and chimera libraries.
Trudeau, Devin L. +2 more
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Homologous Recombination in Eukaryotes
2012Homologous recombination (HR) is a mechanistically conserved pathway that ensures maintenance of genomic integrity. During meiosis, HR results in DNA crossover events between homologous chromosomes that produce the genetic diversity inherent in germ cells.
Richard Fishel, Ravindra Amunugama
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Hotspots of homologous recombination
Experientia, 1994Homologous recombination occurs at higher than average frequency at and near hotspots. Hotspots are special nucleotide sequences recognized by proteins that promote, directly or indirectly, a rate limiting step of recombination. This review focuses on two well-studied examples, the Chi sites of the bacterium Escherichia coli and the M26 site of the ...
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Homologous recombination in plants
Experientia, 1994In plants three different approaches have been used to study homologous DNA recombination; extrachromosomal recombination (ECR) between transfected DNA molecules, intrachromosomal recombination (ICR) between repeated genes integrated into and resident at the genome and recombination between introduced DNA and homologous sequences in the genome (gene ...
Puchta, H., Swoboda, P., Hohn, B.
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Mechanism of Eukaryotic Homologous Recombination
Annual Review of Biochemistry, 2008Homologous recombination (HR) serves to eliminate deleterious lesions, such as double-stranded breaks and interstrand crosslinks, from chromosomes. HR is also critical for the preservation of replication forks, for telomere maintenance, and chromosome segregation in meiosis I.
Hannah L. Klein +2 more
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Role of SIRT1 in homologous recombination
DNA Repair, 2010The class III histone deacetylase (HDAC) SIRT1 plays a role in the metabolism, aging, and carcinogenesis of organisms and regulates senescence and apoptosis in cells. Recent reports revealed that SIRT1 also deacetylates several DNA double-strand break (DSB) repair proteins. However, its exact functions in DNA repair remained elusive. Using nuclear foci
Andreea Csernok +5 more
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Homologous recombination in a mammalian plasmid
Molecular and General Genetics MGG, 1990Bovine papillomavirus (BPV) shuttle vectors replicate as a circular plasmid in mouse cell nuclei without impairing host cell viability. We used these vectors to analyze homologous recombination in mammalian cells. When several BPV-based plasmids carrying direct repeats were introduced into C127 cells, we detected many recombinant plasmid molecules that
Ichizo Kobayashi +2 more
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Role of homologous recombination in carcinogenesis
Experimental and Molecular Pathology, 2003Cancer develops when cells no longer follow their normal pattern of controlled growth. In the absence or disregard of such regulation, resulting from changes in their genetic makeup, these errant cells acquire a growth advantage, expanding into precancerous clones.
Robert H. Schiestl +1 more
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Quality control of homologous recombination
Cellular and Molecular Life Sciences, 2014Exogenous and endogenous genotoxic agents, such as ionizing radiation and numerous chemical agents, cause DNA double-strand breaks (DSBs), which are highly toxic and lead to genomic instability or tumorigenesis if not repaired accurately and efficiently.
Jun Huang, Ting Liu
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Metabolic regulation of homologous recombination repair by MRE11 lactylation
Cell, 2023Yuping Chen +26 more
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