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Methods for Homologous Recombination in Drosophila [PDF]
, 2008 We present detailed protocols for two methods of gene targeting in Drosophila. The first, ends-out targeting, is identical in concept to gene replacement techniques used routinely in mammalian and yeast cells. In Drosophila, the targeted gene is replaced by the marker gene white + (although options exist to generate unmarked targeted alleles).
Kent G. Golic +2 more
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Homologous Recombination—Enzymes and Pathways
EcoSal Plus, 2012Homologous recombination is an ubiquitous process that shapes genomes and repairs DNA damage. The reaction is classically divided into three phases: presynaptic, synaptic, and postsynaptic. In Escherichia coli , the presynaptic phase involves either RecBCD or RecFOR proteins, which act on DNA double-stranded ends ...
Bénédicte Michel, David R. F. Leach
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Biochemistry of eukaryotic homologous recombination
2006The biochemistry of eukaryotic homologous recombination caught fire with the discovery that Rad51 is the eukaryotic homolog of the bacterial RecA and T4 UvsX proteins; and this field is still hot. The core reaction of homologous recombination, homology search and DNA strand invasion, along with the proteins catalyzing it, are conserved throughout ...
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BARD1 reads H2A lysine 15 ubiquitination to direct homologous recombination
Nature, 2021Jordan R. Becker +5 more
semanticscholar +1 more source
Gene Replacement by Homologous Recombination
2019While homologous recombination-based gene replacement is about to be supplanted by more modern approaches, it is still retaining usefulness for genes that prove to be poor targets for CRISPR/cas-based approaches. Homologous recombination has proven to be relatively robust to minor sequence mismatches between GOI-flanking sequences and the gene ...
Joachim Clos, Henner Zirpel
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Activation of homologous recombination in G1 preserves centromeric integrity
Nature, 2021D. Yilmaz +7 more
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Homologous Recombination Deficiency in Breast Cancer: A Clinical Review.
JCO Precision Oncology, 2017BRCA1 and BRCA2 germline mutation-associated breast cancers are known to be deficient in the process of homologous recombination and often respond favorably to drugs targeting this important DNA repair pathway.
W. D. den Brok +6 more
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Homologous Recombination in Mammals
2012Homologous recombination (HR) is a fundamental process that is conserved in all species and is essential for maintaining genome stability while facilitating genetic diversity but avoiding genetic instability. As such, HR is involved in numerous fundamental biological processes, controlling a balance of genetic stability/diversity instability.
Bernard S. Lopez +4 more
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Involvement of Homologous Recombination in Carcinogenesis
2007DNA alterations of every type are associated with the incidence of carcinogenesis, often on the genomic scale. Although homologous recombination (HR) is an important pathway of DNA repair, evidence is accumulating that deleterious genomic rearrangements can result from HR. It therefore follows that HR events may play a causative role in carcinogenesis.
Alexander J.R. Bishop +2 more
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Homologous recombination as a mechanism of carcinogenesis
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2001Cancer develops when cells no longer follow their normal pattern of controlled growth. In the absence or disregard of such regulation, resulting from changes in their genetic makeup, these errant cells acquire a growth advantage, expanding into pre-cancerous clones.
Alexander J.R. Bishop +1 more
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