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Role of SIRT1 in homologous recombination
DNA Repair, 2010The class III histone deacetylase (HDAC) SIRT1 plays a role in the metabolism, aging, and carcinogenesis of organisms and regulates senescence and apoptosis in cells. Recent reports revealed that SIRT1 also deacetylates several DNA double-strand break (DSB) repair proteins. However, its exact functions in DNA repair remained elusive. Using nuclear foci
Andreea Csernok +5 more
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Role of homologous recombination in carcinogenesis
Experimental and Molecular Pathology, 2003Cancer develops when cells no longer follow their normal pattern of controlled growth. In the absence or disregard of such regulation, resulting from changes in their genetic makeup, these errant cells acquire a growth advantage, expanding into precancerous clones.
Robert H. Schiestl +1 more
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Homologous recombination in a mammalian plasmid
Molecular and General Genetics MGG, 1990Bovine papillomavirus (BPV) shuttle vectors replicate as a circular plasmid in mouse cell nuclei without impairing host cell viability. We used these vectors to analyze homologous recombination in mammalian cells. When several BPV-based plasmids carrying direct repeats were introduced into C127 cells, we detected many recombinant plasmid molecules that
Ichizo Kobayashi +2 more
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Metabolic regulation of homologous recombination repair by MRE11 lactylation
Cell, 2023Yuping Chen +26 more
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Quality control of homologous recombination
Cellular and Molecular Life Sciences, 2014Exogenous and endogenous genotoxic agents, such as ionizing radiation and numerous chemical agents, cause DNA double-strand breaks (DSBs), which are highly toxic and lead to genomic instability or tumorigenesis if not repaired accurately and efficiently.
Jun Huang, Ting Liu
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Methods for Homologous Recombination in Drosophila [PDF]
, 2008 We present detailed protocols for two methods of gene targeting in Drosophila. The first, ends-out targeting, is identical in concept to gene replacement techniques used routinely in mammalian and yeast cells. In Drosophila, the targeted gene is replaced by the marker gene white + (although options exist to generate unmarked targeted alleles).
Kent G. Golic +2 more
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Biochemistry of eukaryotic homologous recombination
2006The biochemistry of eukaryotic homologous recombination caught fire with the discovery that Rad51 is the eukaryotic homolog of the bacterial RecA and T4 UvsX proteins; and this field is still hot. The core reaction of homologous recombination, homology search and DNA strand invasion, along with the proteins catalyzing it, are conserved throughout ...
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Homologous Recombination—Enzymes and Pathways
EcoSal Plus, 2012Homologous recombination is an ubiquitous process that shapes genomes and repairs DNA damage. The reaction is classically divided into three phases: presynaptic, synaptic, and postsynaptic. In Escherichia coli , the presynaptic phase involves either RecBCD or RecFOR proteins, which act on DNA double-stranded ends ...
Bénédicte Michel, David R. F. Leach
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BARD1 reads H2A lysine 15 ubiquitination to direct homologous recombination
Nature, 2021Jordan R. Becker +5 more
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Activation of homologous recombination in G1 preserves centromeric integrity
Nature, 2021D. Yilmaz +7 more
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