Results 351 to 360 of about 773,827 (377)

Homologous Recombination—Enzymes and Pathways

EcoSal Plus, 2012
Homologous recombination is an ubiquitous process that shapes genomes and repairs DNA damage. The reaction is classically divided into three phases: presynaptic, synaptic, and postsynaptic. In Escherichia coli , the presynaptic phase involves either RecBCD or RecFOR proteins, which act on DNA double-stranded ends ...
Bénédicte Michel, David R. F. Leach
openaire   +2 more sources

BARD1 reads H2A lysine 15 ubiquitination to direct homologous recombination

Nature, 2021
Jordan R. Becker, Gillian Clifford, Clara Bonnet, Anja Groth, M. D. Wilson, J. R. Chapman   +5 more
semanticscholar   +1 more source

Activation of homologous recombination in G1 preserves centromeric integrity

Nature, 2021
D. Yilmaz, Audrey Furst, K. Meaburn, Aleksandra Lezaja, Yanlin Wen, M. Altmeyer, B. Reina-San-Martin, Evi Soutoglou   +7 more
semanticscholar   +1 more source

Gene Replacement by Homologous Recombination

2019
While homologous recombination-based gene replacement is about to be supplanted by more modern approaches, it is still retaining usefulness for genes that prove to be poor targets for CRISPR/cas-based approaches. Homologous recombination has proven to be relatively robust to minor sequence mismatches between GOI-flanking sequences and the gene ...
Joachim Clos, Henner Zirpel
openaire   +3 more sources

Homologous Recombination in Mammals

2012
Homologous recombination (HR) is a fundamental process that is conserved in all species and is essential for maintaining genome stability while facilitating genetic diversity but avoiding genetic instability. As such, HR is involved in numerous fundamental biological processes, controlling a balance of genetic stability/diversity instability.
Bernard S. Lopez, Bernard S. Lopez, Aurélia Barascu, Aurélia Barascu, Anastazja Grabarz   +4 more
openaire   +2 more sources

Involvement of Homologous Recombination in Carcinogenesis

2007
DNA alterations of every type are associated with the incidence of carcinogenesis, often on the genomic scale. Although homologous recombination (HR) is an important pathway of DNA repair, evidence is accumulating that deleterious genomic rearrangements can result from HR. It therefore follows that HR events may play a causative role in carcinogenesis.
Alexander J.R. Bishop, Ramune Reliene, Robert H. Schiestl   +2 more
openaire   +3 more sources

Homologous Recombination in Plants: An Antireview

2010
Homologous recombination (HR) is a central cellular process involved in many aspects of genome maintenance such as DNA repair, replication, telomere maintenance, and meiotic chromosomal segregation. HR is highly conserved among eukaryotes, contributing to genome stability as well as to the generation of genetic diversity.
Michal Lieberman-Lazarovich, Avraham A. Levy   +1 more
openaire   +3 more sources

Mechanisms for homologous recombination [PDF]

Nature, 1985
Jean-Luc Rossignol, Alain Nicolas
openaire   +2 more sources

Homologous recombination as a mechanism of carcinogenesis

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2001
Cancer develops when cells no longer follow their normal pattern of controlled growth. In the absence or disregard of such regulation, resulting from changes in their genetic makeup, these errant cells acquire a growth advantage, expanding into pre-cancerous clones.
Alexander J.R. Bishop, Robert H. Schiestl   +1 more
openaire   +3 more sources

HOMOLOGOUS RECOMBINATION IN MAMMALIAN CELLS

Annual Review of Genetics, 1989
This review focuses on three approaches used to study recombination mediated by cellular functions: (a) extrachromosomal recombination between transfected DNA molecules; (b) chromosomal recombination between repeated genes stably incorporated in the genome; and (c) targeted recombination between introduced DNA molecules and homologous sequences in the ...
A. S. Waldman, R. J. Bollag, R. M. Liskay   +2 more
openaire   +3 more sources