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Gene Replacement by Homologous Recombination
2019While homologous recombination-based gene replacement is about to be supplanted by more modern approaches, it is still retaining usefulness for genes that prove to be poor targets for CRISPR/cas-based approaches. Homologous recombination has proven to be relatively robust to minor sequence mismatches between GOI-flanking sequences and the gene ...
Joachim Clos, Henner Zirpel
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Homologous Recombination in Mammals
2012Homologous recombination (HR) is a fundamental process that is conserved in all species and is essential for maintaining genome stability while facilitating genetic diversity but avoiding genetic instability. As such, HR is involved in numerous fundamental biological processes, controlling a balance of genetic stability/diversity instability.
Bernard S. Lopez +4 more
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Involvement of Homologous Recombination in Carcinogenesis
2007DNA alterations of every type are associated with the incidence of carcinogenesis, often on the genomic scale. Although homologous recombination (HR) is an important pathway of DNA repair, evidence is accumulating that deleterious genomic rearrangements can result from HR. It therefore follows that HR events may play a causative role in carcinogenesis.
Alexander J.R. Bishop +2 more
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Homologous Recombination in Plants: An Antireview
2010Homologous recombination (HR) is a central cellular process involved in many aspects of genome maintenance such as DNA repair, replication, telomere maintenance, and meiotic chromosomal segregation. HR is highly conserved among eukaryotes, contributing to genome stability as well as to the generation of genetic diversity.
Michal Lieberman-Lazarovich +1 more
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Mechanisms for homologous recombination [PDF]
Nature, 1985 Jean-Luc Rossignol, Alain Nicolas
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Homologous recombination as a mechanism of carcinogenesis
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2001Cancer develops when cells no longer follow their normal pattern of controlled growth. In the absence or disregard of such regulation, resulting from changes in their genetic makeup, these errant cells acquire a growth advantage, expanding into pre-cancerous clones.
Alexander J.R. Bishop +1 more
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Homologous Recombination Deficiency in Breast Cancer: A Clinical Review.
JCO Precision Oncology, 2017BRCA1 and BRCA2 germline mutation-associated breast cancers are known to be deficient in the process of homologous recombination and often respond favorably to drugs targeting this important DNA repair pathway.
W. D. den Brok +6 more
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HOMOLOGOUS RECOMBINATION IN MAMMALIAN CELLS
Annual Review of Genetics, 1989This review focuses on three approaches used to study recombination mediated by cellular functions: (a) extrachromosomal recombination between transfected DNA molecules; (b) chromosomal recombination between repeated genes stably incorporated in the genome; and (c) targeted recombination between introduced DNA molecules and homologous sequences in the ...
A. S. Waldman +2 more
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Mechanism of Homologous Recombination
2016Homologous recombination (HR) maintains genome stability by repairing DNA double-strand breaks and gaps and restarting replication forks. It is an error-free pathway that uses a homologous sequence in the genome to copy the damaged genetic information.
Marek Sebesta, Lumir Krejci
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Homologous recombination: ends as the means
Trends in Plant Science, 2002Broken chromosomal ends in somatic cells of higher plants frequently heal by the ligation of DNA ends to unrelated sequences or to sequences with micro-homologies. This pathway of DNA-strand-break repair is the bane of gene-targeting attempts in plants.
Animesh Ray, Marybeth Langer
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