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Mechanism of Homologous Recombination
2016Homologous recombination (HR) maintains genome stability by repairing DNA double-strand breaks and gaps and restarting replication forks. It is an error-free pathway that uses a homologous sequence in the genome to copy the damaged genetic information.
Marek Sebesta, Lumir Krejci
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Homologous recombination: ends as the means
Trends in Plant Science, 2002Broken chromosomal ends in somatic cells of higher plants frequently heal by the ligation of DNA ends to unrelated sequences or to sequences with micro-homologies. This pathway of DNA-strand-break repair is the bane of gene-targeting attempts in plants.
Animesh Ray, Marybeth Langer
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Altering the Genome by Homologous Recombination [PDF]
Science, 1989 Homologous recombination between DNA sequences residing in the chromosome and newly introduced, cloned DNA sequences (gene targeting) allows the transfer of any modification of the cloned gene into the genome of a living cell. This article discusses the current status of gene targeting with particular emphasis on germ line modification of the mouse ...
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Homologous Recombination: A ring for a warhead
Current Biology, 1994The active 'warhead' RuvB of the Escherichia coli protein that catalyzes the branch-migration step of homologous recombination is a helicase that binds DNA as a double-ring oligomer.
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The cell biology of homologous recombination
2006Discontinuities in double-stranded DNA, such as DNA double-strand breaks (DSBs), pose a threat to genome stability. Homologous recombination is a process that not only effectively repairs DSBs, but also promotes preservation of genome integrity by repairing DNA discontinuities arising during DNA replication.
Roland Kanaar +2 more
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Recombination Hotspots in Nonallelic Homologous Recombination
2007Rearrangement breakpoints resulting from nonallelic homologous recombination (NAHR) are typically clustered within small, well-defined portions of the segmental duplications that promote the rearrangement. These NAHR “hotspots” have been identified in every NAHR-promoted rearrangement in which breakpoint junctions have been sequenced in sufficient ...
Matthew E. Hurles, James R. Lupski
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Recombination | Homologous Recombination in Meiosis
Encyclopedia of Biological Chemistry III, 2021N. M. Hollingsworth, Hani S. Zaher
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Detecting the mutational signature of homologous recombination deficiency in clinical samples
Nature Genetics, 2019D. Gulhan +4 more
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